SPYRAL PIVOTAL - SPYRAL HTN-OFF MED Study
Public ClinicalTrials.gov record NCT02439749. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
Global Clinical Study of Renal Denervation With the Symplicity Spyral™ Multi-electrode Renal Denervation System in Patients With Uncontrolled Hypertension in the Absence of Antihypertensive Medications (SPYRAL PIVOTAL - SPYRAL HTN-OFF MED)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The purpose of this study is to test the hypothesis that renal denervation decreases blood pressure and is safe when studied in the absence of antihypertensive medications.
Study identification
- NCT ID
- NCT02439749
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Not applicable
- Enrollment
- 366 participants
Conditions and interventions
Conditions
Interventions
Device · Procedure
Eligibility (public fields only)
- Age range
- 20 Years to 80 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jun 2015 (Actual)
- Primary completion
- Apr 30, 2020 (Actual)
- Completion
- Oct 25, 2023 (Actual)
- Last update posted
- Mar 28, 2025
2015 – 2023
United States locations
- U.S. sites
- 30
- U.S. states
- 23
- U.S. cities
- 29
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Heart Center Research, LLC | Huntsville | Alabama | 35801 | — |
| Honor Health Research Institute | Scottsdale | Arizona | 85258 | — |
| Kaiser Permanente LA Medical Center | Los Angeles | California | 90027 | — |
| Stanford Hospital and Clinics | Stanford | California | 94305 | — |
| Yale New Haven Hospital | New Haven | Connecticut | 06520 | — |
| Baptist Medical Center Jacksonville | Jacksonville | Florida | 32207 | — |
| Tallahassee Research Institute | Tallahassee | Florida | 32308 | — |
| Emory University Hospital Midtown | Atlanta | Georgia | 30308 | — |
| Piedmont Heart Institute | Atlanta | Georgia | 30309 | — |
| Iowa Heart Center | West Des Moines | Iowa | 50266 | — |
| University of Kentucky | Lexington | Kentucky | 40536 | — |
| St Joseph Mercy Oakland | Pontiac | Michigan | 48341 | — |
| Providence Hospital | Southfield | Michigan | 48075 | — |
| Minneapolis Heart Institute Foundation | Minneapolis | Minnesota | 55407 | — |
| Hattiesburg Clinic | Hattiesburg | Mississippi | 39401 | — |
| Cardiology Associates Research LLC | Tupelo | Mississippi | 38801 | — |
| Barnes-Jewish Hospital | St Louis | Missouri | 63110 | — |
| Saint Barnabas Medical Center | Livingston | New Jersey | 07039 | — |
| North Shore University Hospital | Manhasset | New York | 11030 | — |
| Mount Sinai Medical Center | New York | New York | 10029 | — |
| Duke University Medical Center | Durham | North Carolina | 27710 | — |
| University Hospitals Cleveland Medical Center | Cleveland | Ohio | 44106 | — |
| PinnacleHealth Cardiovascular Institute | Harrisburg | Pennsylvania | 17011 | — |
| Hospital of the University of Pennsylvania | Philadelphia | Pennsylvania | 19104 | — |
| The Miriam Hospital | Providence | Rhode Island | 02906 | — |
| AnMed Health | Anderson | South Carolina | 29621 | — |
| Centennial Medical Center | Nashville | Tennessee | 37203 | — |
| Baylor Heart & Vascular Hospital | Dallas | Texas | 75226 | — |
| Charleston Area Medical Center | Charleston | West Virginia | 25304 | — |
| Aurora St. Luke's Medical Center | Milwaukee | Wisconsin | 53215 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 17 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT02439749, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Mar 28, 2025 · Synced Oct 25, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT02439749 live on ClinicalTrials.gov.