A Proof-of-Concept Study of Faricimab (RO6867461) in Participants With Choroidal Neovascularization (CNV) Secondary to Age-Related Macular Degeneration (AMD)
Public ClinicalTrials.gov record NCT02484690. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Multiple-Center, Multiple-Dose and Regimen, Randomized, Active Comparator Controlled, Double-Masked, Parallel Group, 36 Week Study to Investigate the Safety, Tolerability, Pharmacokinetics, and Efficacy of RO6867461 Administered Intravitreally in Patients With Choroidal Neovascularization Secondary to Age-Related Macular Degeneration
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This multiple-center, multiple-dose and regimen, randomized, double-masked active comparator-controlled, double-masked, five parallel group, 36-week study will evaluate the efficacy, safety, tolerability, and pharmacokinetics of faricimab (RO6867461) in participants with choroidal neovascularization (CNV) secondary to age-related macular degeneration (AMD). The study was designed to allow the evaluation of RO6867461 in a treatment-naive population (comparison of Arms A, B, C, and D) and an anti-VEGF-incomplete responder population that met a predefined criterion at Week 12 (comparison between Arms A and E). Only one eye per participant was chosen as the study eye.
Study identification
- NCT ID
- NCT02484690
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 273 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 50 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Aug 11, 2015 (Actual)
- Primary completion
- Sep 26, 2017 (Actual)
- Completion
- Sep 26, 2017 (Actual)
- Last update posted
- Nov 12, 2020
2015 – 2017
United States locations
- U.S. sites
- 52
- U.S. states
- 24
- U.S. cities
- 49
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Associated Retina Consultants | Phoenix | Arizona | 85020 | — |
| Retinal Consultants of Arizona | Phoenix | Arizona | 85053 | — |
| California Retina Consultants | Bakersfield | California | 93309 | — |
| Retina-Vitreous Associates Medical Group | Beverly Hills | California | 90211 | — |
| The Retina Partners | Encino | California | 91436 | — |
| Retina Consultants, San Diego | Poway | California | 92064 | — |
| Orange County Retina Med Group | Santa Ana | California | 92705 | — |
| Bay Area Retina Associates | Walnut Creek | California | 94598 | — |
| American Institute of Research | Whittier | California | 90603 | — |
| Retina Consultants of Southern | Colorado Springs | Colorado | 80909 | — |
| Colorado Retina Associates, PC | Golden | Colorado | 80401 | — |
| New England Retina Associates | Hamden | Connecticut | 06518 | — |
| Retina Health Center | Fort Myers | Florida | 33907 | — |
| National Ophthalmic Research Institute | Fort Myers | Florida | 33912 | — |
| Florida Eye Associates | Melbourne | Florida | 32901 | — |
| Central Florida Retina | Orlando | Florida | 32806 | — |
| Retina Care Specialists | Palm Beach Gardens | Florida | 33410 | — |
| Retina Vitreous Assoc of FL | St. Petersburg | Florida | 33711 | — |
| Southern Vitreoretinal Assoc | Tallahassee | Florida | 32308 | — |
| Southeast Retina Center | Augusta | Georgia | 30909 | — |
| Georgia Retina PC | Marietta | Georgia | 30060 | — |
| Midwest Eye Institute Northside | Indianapolis | Indiana | 46290 | — |
| Paducah Retinal Center | Paducah | Kentucky | 42001 | — |
| Retina Group of Washington | Chevy Chase | Maryland | 20815 | — |
| National Retina Institute | Towson | Maryland | 21204 | — |
| Vitreo-Retinal Associates, PC | Worcester | Massachusetts | 01605 | — |
| Vitreoretinal Surgery | Edina | Minnesota | 55435 | — |
| Retina Associates of NJ | Toms River | New Jersey | 08755 | — |
| Eye Associates of New Mexico | Albuquerque | New Mexico | 87102 | — |
| Long Is. Vitreoretinal Consult | Great Neck | New York | 11021 | — |
| Opthalmic Consultants of LI | Lynbrook | New York | 11563 | — |
| Retina Assoc of Western NY | Rochester | New York | 14620 | — |
| The Retina Consultants | Slingerlands | New York | 12159 | — |
| Western Carolina Retinal Associate PA | Asheville | North Carolina | 28803 | — |
| Char Eye Ear &Throat Assoc | Charlotte | North Carolina | 28210 | — |
| OSU Eye Physicians & Surgeons | Columbus | Ohio | 43212 | — |
| Oregon Retina, LLP | Eugene | Oregon | 97401 | — |
| Oregon Retina institute | Medford | Oregon | 97504 | — |
| Retina Northwest | Portland | Oregon | 97221 | — |
| Mid Atlantic Retina | Philadelphia | Pennsylvania | 19107 | — |
| Palmetto Retina Center | West Columbia | South Carolina | 29169 | — |
| Southeastern Retina Associates Chattanooga | Chattanooga | Tennessee | 37421 | — |
| Charles Retina Institute | Germantown | Tennessee | 38138 | — |
| Tennessee Retina PC. | Nashville | Tennessee | 37203 | — |
| W Texas Retina Consultants PA | Abilene | Texas | 79606 | — |
| Austin Retina Associates | Austin | Texas | 78705 | — |
| Retina Research Center | Austin | Texas | 78705 | — |
| Retina Consultants of Houston | Houston | Texas | 77030 | — |
| Strategic Clinical Research Group, LLC | Willow Park | Texas | 76087 | — |
| Retina Associates of Utah | Salt Lake City | Utah | 84107 | — |
| Univ of Virginia Ophthalmology | Charlottesville | Virginia | 22903 | — |
| Spokane Eye Clinical Research | Spokane | Washington | 99204 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT02484690, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Nov 12, 2020 · Synced Oct 21, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT02484690 live on ClinicalTrials.gov.