Phase 3 Randomized, Double-blind, Controlled Study of ICT-107 in Glioblastoma
Public ClinicalTrials.gov record NCT02546102. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 3 Randomized Double-blind, Controlled Study of ICT-107 With Maintenance Temozolomide (TMZ) in Newly Diagnosed Glioblastoma Following Resection and Concomitant TMZ Chemoradiotherapy
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
ICT-107 consists of dendritic cells, prepared from autologous mononuclear cells that are pulsed with six synthetic peptides that were derived from tumor associated antigens (TAA) present on glioblastoma tumor cells. This is a Phase 3 study to evaluate ICT-107 in patients with newly diagnosed glioblastoma. Subjects will be randomized to receive standard of care chemoradiation (temozolomide (TMZ) with either ICT-107 or a blinded control. Reinfusion with the pulsed dendritic cells should stimulate cytotoxic T cells to specifically target glioblastoma tumour cells.
Study identification
- NCT ID
- NCT02546102
- Recruitment status
- Suspended
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 234 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Dec 2024 (Estimated)
- Primary completion
- Dec 2025 (Estimated)
- Completion
- Dec 2025 (Estimated)
- Last update posted
- Apr 3, 2024
2024 – 2025
United States locations
- U.S. sites
- 58
- U.S. states
- 27
- U.S. cities
- 46
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| University of Alabama at Birmingham | Birmingham | Alabama | 35294 | — |
| Dignity Health - St. Joseph's Hospital and Medical Center | Phoenix | Arizona | 85013 | — |
| City of Hope Cancer Center | Duarte | California | 91010 | — |
| UCSD Moores Cancer Center | La Jolla | California | 92093 | — |
| Southern California Permanente Medical Group | Los Angeles | California | 90027 | — |
| University of Southern California | Los Angeles | California | 90033 | — |
| Cedars Sinai Medical Center | Los Angeles | California | 90048 | — |
| University of California Irvine Chao Family Cancer Center | Orange | California | 92868 | — |
| Kaiser Permanente | Redwood City | California | 94063 | — |
| Kaiser Permanente | Sacramento | California | 95825 | — |
| John Wayne Cancer Institute | Santa Monica | California | 90404 | — |
| Stanford Cancer Institute | Stanford | California | 95124 | — |
| University of Colorado Denver | Aurora | Colorado | 80045 | — |
| Associated Neurologists of Southern Connecticut | Fairfield | Connecticut | 06824 | — |
| Smilow Cancer Hospital | New Haven | Connecticut | 06519 | — |
| Christiana Care Health Services | Newark | Delaware | 19711 | — |
| Delray Medical Center | Boca Raton | Florida | 33484 | — |
| Boca Raton Regional Hospital Lynn Cancer Institute | Boca Raton | Florida | 33486 | — |
| Piedmont Hospital | Atlanta | Georgia | 30309 | — |
| Georgia Regents University | Augusta | Georgia | 30912 | — |
| Northwestern University | Chicago | Illinois | 60611 | — |
| NorthShore University Health System | Evanston | Illinois | 60201 | — |
| University of Iowa | Iowa City | Iowa | 52242 | — |
| University of Kentucky | Lexington | Kentucky | 40536 | — |
| Norton Cancer Institute | Louisville | Kentucky | 40202 | — |
| Johns Hopkins University School of Medicine | Baltimore | Maryland | 21287 | — |
| Dana Farber Cancer Institute | Boston | Massachusetts | 02114 | — |
| Massachusetts General Hospital | Boston | Massachusetts | 02114 | — |
| Harvard Medical School Beth Israel Deaconess Medical Center | Boston | Massachusetts | 02215 | — |
| University of Michigan Health System | Ann Arbor | Michigan | 48109 | — |
| John Nasseff Neuroscience Institute | Minneapolis | Minnesota | 55407 | — |
| Metro-Minnesota Community Oncology Research Consortium | Saint Louis Park | Minnesota | 55416 | — |
| JFK New Jersey Neuroscience Institute | Edison | New Jersey | 08820 | — |
| New Mexico Cancer Care Alliance | Albuquerque | New Mexico | 87131 | — |
| North Shore University Hospital | Lake Success | New York | 11042 | — |
| Perlmutter Cancer Center | New York | New York | 10016 | — |
| Mount Sinai Medical Center | New York | New York | 10029 | — |
| Columbia University Medical Center | New York | New York | 10032 | — |
| Weil Cornell Medical Center | New York | New York | 10065 | — |
| University of Rochester Medical Center | Rochester | New York | 14642 | — |
| Wake Forest University Health Sciences | Winston-Salem | North Carolina | 27157 | — |
| The Ohio State University Medical Center | Columbus | Ohio | 43210 | — |
| University of Oklahoma Health Sciences Center | Oklahoma City | Oklahoma | 73104 | — |
| Penn State College of Medicine Hershey Medical Center | Hershey | Pennsylvania | 17033 | — |
| University of Pennsylvania | Philadelphia | Pennsylvania | 19104 | — |
| Thomas Jefferson University Hospital | Philadelphia | Pennsylvania | 19107 | — |
| University of Pittsburgh Medical Center Cancer Pavilion | Pittsburgh | Pennsylvania | 15232 | — |
| University of Tennessee Medical Cancer Institute | Knoxville | Tennessee | 37920 | — |
| Texas Oncology | Austin | Texas | 78705 | — |
| Baylor Health Charles Sammons Cancer Center | Dallas | Texas | 75246 | — |
| University of Texas Southwestern Medical Center | Dallas | Texas | 75390 | — |
| Houston Methodist Hospital | Houston | Texas | 77030 | — |
| University of Texas Health Science Center Memorial Hermann Hospital | Houston | Texas | 77030 | — |
| CTRC at UTHSCSA | San Antonio | Texas | 78229 | — |
| Huntsman Cancer Institute | Salt Lake City | Utah | 84112 | — |
| University of Virginia Health System | Charlottesville | Virginia | 22903 | — |
| Ivy Center for Advanced Brain Tumor Treatment Swedish Medical Center | Seattle | Washington | 98122 | — |
| University of Washington Medical Center | Seattle | Washington | 98195 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 7 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT02546102, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Apr 3, 2024 · Synced Oct 21, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT02546102 live on ClinicalTrials.gov.