ClinicalTrials.gov record
Comparison of Sacubitril/Valsartan Versus Enalapril on Effect on NT-proBNP in Patients Stabilized From an Acute Heart Failure Episode.
ClinicalTrials.gov ID: NCT02554890
Public ClinicalTrials.gov record NCT02554890. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
ClinicalTrials.gov public records Last synced Apr 22, 2026, 11:18 AM EDT
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Multicenter, Randomized, Double-blind, Double Dummy, Parallel Group, Active-controlled 8-week Study to Evaluate the Effect of Sacubitril/Valsartan (LCZ696) Versus Enalapril on Changes in NT-proBNP and Safety and Tolerability of In-hospital Initiation of LCZ696 Compared to Enalapril in HFrEF Patients Who Have Been Stabilized Following Hospitalization for Acute Decompensated Heart Failure (ADHF).
Study identification
- NCT ID
- NCT02554890
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 4
- Lead sponsor
- Novartis Pharmaceuticals
- Industry
- Enrollment
- 887 participants
Conditions and interventions
Conditions
Interventions
- Enalapril Drug
- enalapril matching placebo Drug
- sacubitril/valsartan (LCZ696) Drug
- sacubitril/valsartan (LCZ696) matching placebo Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Not listed
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Apr 28, 2016
- Primary completion
- Jun 28, 2018
- Completion
- Jul 23, 2018
- Last update posted
- Jan 4, 2021
2016 – 2018
United States locations
- U.S. sites
- 123
- U.S. states
- 40
- U.S. cities
- 108
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Novartis Investigative Site | Birmingham | Alabama | 35294 | — |
| Novartis Investigative Site | Fort Smith | Arkansas | 72901 | — |
| Novartis Investigative Site | Little Rock | Arkansas | 72205 | — |
| Novartis Investigative Site | Bakersfield | California | 93301 | — |
| Novartis Investigative Site | Fresno | California | 93701 | — |
| Novartis Investigative Site | Long Beach | California | 90806 | — |
| Novartis Investigative Site | Los Angeles | California | 90033 | — |
| Novartis Investigative Site | Los Angeles | California | 90073 | — |
| Novartis Investigative Site | Orange | California | 92868 | — |
| Novartis Investigative Site | Pasadena | California | 91105 | — |
| Novartis Investigative Site | Sacramento | California | 95817-1460 | — |
| Novartis Investigative Site | San Diego | California | 92123 | — |
| Novartis Investigative Site | San Marino | California | 91108 | — |
| Novartis Investigative Site | San Pablo | California | 94806 | — |
| Novartis Investigative Site | Stanford | California | 94305 | — |
| Novartis Investigative Site | Denver | Colorado | — | — |
| Novartis Investigative Site | Littleton | Colorado | 80120 | — |
| Novartis Investigative Site | Bridgeport | Connecticut | 06610 | — |
| Novartis Investigative Site | Hartford | Connecticut | 06102 | — |
| Novartis Investigative Site | Hartford | Connecticut | 06105 | — |
| Novartis Investigative Site | West Haven | Connecticut | 06516 | — |
| Novartis Investigative Site | Washington D.C. | District of Columbia | 20422 | — |
| Novartis Investigative Site | Atlantis | Florida | 33462 | — |
| Novartis Investigative Site | Daytona Beach | Florida | 32117 | — |
| Novartis Investigative Site | Fort Lauderdale | Florida | 33308 | — |
| Novartis Investigative Site | Gainesville | Florida | 32608 | — |
| Novartis Investigative Site | Gainesville | Florida | 32610 | — |
| Novartis Investigative Site | Hollywood | Florida | 33021 | — |
| Novartis Investigative Site | Jacksonville | Florida | 32209-6511 | — |
| Novartis Investigative Site | Jacksonville | Florida | 32216 | — |
| Novartis Investigative Site | Lakeland | Florida | 33805 | — |
| Novartis Investigative Site | Sarasota | Florida | 34239 | — |
| Novartis Investigative Site | Tampa | Florida | 33612 | — |
| Novartis Investigative Site | Tampa | Florida | 34667 | — |
| Novartis Investigative Site | Vero Beach | Florida | 32960 | — |
| Novartis Investigative Site | Winter Haven | Florida | 33881 | — |
| Novartis Investigative Site | Augusta | Georgia | 30901 | — |
| Novartis Investigative Site | Macon | Georgia | 31201 | — |
| Novartis Investigative Site | Marietta | Georgia | 30060 | — |
| Novartis Investigative Site | Boise | Idaho | 83702 | — |
| Novartis Investigative Site | Aurora | Illinois | 60504 | — |
| Novartis Investigative Site | Elk Grove Village | Illinois | 60007 | — |
| Novartis Investigative Site | Oakbrook Terrace | Illinois | 60181 | — |
| Novartis Investigative Site | Park Ridge | Illinois | 60068 | — |
| Novartis Investigative Site | Peoria | Illinois | 61606 | — |
| Novartis Investigative Site | Peoria | Illinois | 61614 | — |
| Novartis Investigative Site | Winfield | Illinois | 60190 | — |
| Novartis Investigative Site | Elkhart | Indiana | 46514 | — |
| Novartis Investigative Site | Indianapolis | Indiana | 46202 | — |
| Novartis Investigative Site | Indianapolis | Indiana | 46237 | — |
| Novartis Investigative Site | Muncie | Indiana | 47303-3400 | — |
| Novartis Investigative Site | Richmond | Indiana | 47374 | — |
| Novartis Investigative Site | Des Moines | Iowa | 50314 | — |
| Novartis Investigative Site | Kansas City | Kansas | 66103 | — |
| Novartis Investigative Site | Louisville | Kentucky | 40205 | — |
| Novartis Investigative Site | Louisville | Kentucky | 40245 | — |
| Novartis Investigative Site | Alexandria | Louisiana | 71301 | — |
| Novartis Investigative Site | Baton Rouge | Louisiana | 70808 | — |
| Novartis Investigative Site | Slidell | Louisiana | 70458 | — |
| Novartis Investigative Site | Bangor | Maine | 04401 | — |
| Novartis Investigative Site | Annapolis | Maryland | 21401 | — |
| Novartis Investigative Site | Baltimore | Maryland | 21215 | — |
| Novartis Investigative Site | Boston | Massachusetts | 02215 | — |
| Novartis Investigative Site | Boston | Massachusetts | — | — |
| Novartis Investigative Site | Ann Arbor | Michigan | 48106 | — |
| Novartis Investigative Site | Bay City | Michigan | 48708 | — |
| Novartis Investigative Site | Detroit | Michigan | 48201 | — |
| Novartis Investigative Site | Maplewood | Minnesota | 55109 | — |
| Novartis Investigative Site | Minneapolis | Minnesota | 55417 | — |
| Novartis Investigative Site | Saint Paul | Minnesota | 55101 | — |
| Novartis Investigative Site | Saint Paul | Minnesota | 55102 | — |
| Novartis Investigative Site | Hattiesburg | Mississippi | 39401 | — |
| Novartis Investigative Site | Jackson | Mississippi | 39216 | — |
| Novartis Investigative Site | Kansas City | Missouri | 64108 | — |
| Novartis Investigative Site | Omaha | Nebraska | 68198 | — |
| Novartis Investigative Site | Reno | Nevada | 89502 | — |
| Novartis Investigative Site | Camden | New Jersey | 08103-3117 | — |
| Novartis Investigative Site | Elmer | New Jersey | 08318 | — |
| Novartis Investigative Site | Haddon Heights | New Jersey | 08035 | — |
| Novartis Investigative Site | Newark | New Jersey | 07102 | — |
| Novartis Investigative Site | Brooklyn | New York | 11215 | — |
| Novartis Investigative Site | Buffalo | New York | 14215 | — |
| Novartis Investigative Site | Johnson City | New York | 13790 | — |
| Novartis Investigative Site | Manhasset | New York | 11030 | — |
| Novartis Investigative Site | New York | New York | 10016 | — |
| Novartis Investigative Site | New York | New York | 10029 | — |
| Novartis Investigative Site | New York | New York | 10032 | — |
| Novartis Investigative Site | Poughkeepsie | New York | 12601 | — |
| Novartis Investigative Site | Rochester | New York | 14621 | — |
| Novartis Investigative Site | Staten Island | New York | 10310 | — |
| Novartis Investigative Site | The Bronx | New York | 10461 | — |
| Novartis Investigative Site | The Bronx | New York | 10467-2490 | — |
| Novartis Investigative Site | Chapel Hill | North Carolina | 27599 | — |
| Novartis Investigative Site | Greenville | North Carolina | 27834 | — |
| Novartis Investigative Site | Winston-Salem | North Carolina | 27157 | — |
| Novartis Investigative Site | Grand Forks | North Dakota | 58201 | — |
| Novartis Investigative Site | Cincinnati | Ohio | 45220 | — |
| Novartis Investigative Site | Toledo | Ohio | 43608 | — |
| Novartis Investigative Site | Oklahoma City | Oklahoma | 73122 | — |
| Novartis Investigative Site | Tulsa | Oklahoma | 74104 | — |
| Novartis Investigative Site | Abington | Pennsylvania | 19001 | — |
| Novartis Investigative Site | Camp Hill | Pennsylvania | 17011 | — |
| Novartis Investigative Site | Natrona Heights | Pennsylvania | 15065 | — |
| Novartis Investigative Site | Philadelphia | Pennsylvania | 19102 2293 | — |
| Novartis Investigative Site | Providence | Rhode Island | 02903 | — |
| Novartis Investigative Site | Charleston | South Carolina | 29403 | — |
| Novartis Investigative Site | Greenville | South Carolina | 29615 | — |
| Novartis Investigative Site | Rapid City | South Dakota | 57701 | — |
| Novartis Investigative Site | Nashville | Tennessee | 37203 | — |
| Novartis Investigative Site | Nashville | Tennessee | 37212 | — |
| Novartis Investigative Site | Dallas | Texas | 75204 | — |
| Novartis Investigative Site | Dallas | Texas | 75390 | — |
| Novartis Investigative Site | Houston | Texas | 77030 | — |
| Novartis Investigative Site | Plano | Texas | 75093 | — |
| Novartis Investigative Site | San Antonio | Texas | 78229 | — |
| Novartis Investigative Site | White River Junction | Vermont | 05009 | — |
| Novartis Investigative Site | Charlottesville | Virginia | 22908 | — |
| Novartis Investigative Site | Lynchburg | Virginia | 24501 | — |
| Novartis Investigative Site | Richmond | Virginia | 23298 | — |
| Novartis Investigative Site | Virginia Beach | Virginia | 23454 | — |
| Novartis Investigative Site | Clarksburg | West Virginia | 26301 | — |
| Novartis Investigative Site | Madison | Wisconsin | 53792-1615 | — |
| Novartis Investigative Site | Wausau | Wisconsin | 54401 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT02554890, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jan 4, 2021 · Synced Apr 22, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete protocol, eligibility criteria, and contact information for NCT02554890 live on ClinicalTrials.gov.