Basket Study of Entrectinib (RXDX-101) for the Treatment of Patients With Solid Tumors Harboring NTRK 1/2/3 (Trk A/B/C), ROS1, or ALK Gene Rearrangements (Fusions)
Public ClinicalTrials.gov record NCT02568267. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
An Open-Label, Multicenter, Global Phase 2 Basket Study of Entrectinib for the Treatment of Patients With Locally Advanced or Metastatic Solid Tumors That Harbor NTRK1/2/3, ROS1, or ALK Gene Rearrangements
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This is an open-label, multicenter, global Phase 2 basket study of entrectinib (RXDX-101) for the treatment of patients with solid tumors that harbor an NTRK1/2/3, ROS1, or ALK gene fusion. Patients will be assigned to different baskets according to tumor type and gene fusion.
Study identification
- NCT ID
- NCT02568267
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 534 participants
Conditions and interventions
Conditions
- Breast Cancer
- Cholangiocarcinoma
- Colorectal Cancer
- Head and Neck Neoplasms
- Lymphoma, Large-Cell, Anaplastic
- Melanoma
- Neuroendocrine Tumors
- Non-Small Cell Lung Cancer
- Ovarian Cancer
- Pancreatic Cancer
- Papillary Thyroid Cancer
- Primary Brain Tumors
- Renal Cell Carcinoma
- Sarcomas
- Salivary Gland Cancers
- Adult Solid Tumor
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Nov 19, 2015 (Actual)
- Primary completion
- Jun 30, 2027 (Estimated)
- Completion
- Jun 30, 2027 (Estimated)
- Last update posted
- Aug 25, 2026
2015 – 2027
United States locations
- U.S. sites
- 48
- U.S. states
- 21
- U.S. cities
- 35
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Dignity Health St Joseph's Hospital and Medical Center | Phoenix | Arizona | 85013 | — |
| Mayo Clinic | Phoenix | Arizona | 85054 | — |
| City of Hope Cancer Center | Duarte | California | 91010 | — |
| City of Hope Duarte - Comprehensive Cancer Center, Investigational Drug Services | Duarte | California | 91010 | — |
| Scripps Clinic | La Jolla | California | 92037 | — |
| University of California San Diego Moores Cancer Center | La Jolla | California | 92093 | — |
| Southern California Kaiser Permanente | Los Angeles | California | 90027 | — |
| Univ Of California Irvine College Of Medicine | Orange | California | 92868 | — |
| UCSF Mount Zion Medical Ctr | San Francisco | California | 94115 | — |
| UCSF Mission Bay | San Francisco | California | 94158 | — |
| Sarcoma Oncology Center | Santa Monica | California | 90403 | — |
| Sarcoma Oncology Research Center LLC | Santa Monica | California | 90403 | — |
| University of Colorado Cancer Center | Aurora | Colorado | 80045 | — |
| Yale University | New Haven | Connecticut | 6519 | — |
| Georgetown University Medical Center Lombardi Cancer Center | Washington D.C. | District of Columbia | 20007 | — |
| Florida Cancer Specialists - Sarasota | Sarasota | Florida | 34232 | — |
| H. Lee Moffitt Cancer Center and Research Inst. | Tampa | Florida | 33612-9497 | — |
| Moffitt Cancer Center | Tampa | Florida | 33612-9497 | — |
| University Cancer & Blood Center, LLC | Athens | Georgia | 30607 | — |
| Winship Cancer Institute | Atlanta | Georgia | 30322 | — |
| Southeastern Regional Medical Center, Inc. | Newnan | Georgia | 30265 | — |
| Northwestern University | Chicago | Illinois | 60611 | — |
| Advocate Medical Group - Park Ridge, Luther Lane - Oncology | Park Ridge | Illinois | 60068 | — |
| Midwestern Regional Medical Center | Zion | Illinois | 60099 | — |
| Weinberg Cancer Institution at Franklin Square | Baltimore | Maryland | 21237 | — |
| Massachusetts General Hosp CAR | Boston | Massachusetts | 02114 | — |
| Massachusetts General Hospital | Boston | Massachusetts | 02114 | — |
| Beth Israel Deaconess Medical Center | Boston | Massachusetts | 02215 | — |
| Dana Farber Cancer Institute | Boston | Massachusetts | 02215 | — |
| Karmanos Cancer Center | Detroit | Michigan | 48201 | — |
| Henry Ford Hospital | Detroit | Michigan | 48202 | — |
| Regents of the University of Minnesota | Minneapolis | Minnesota | 55455 | — |
| Washington University | St Louis | Missouri | 63128 | — |
| Comprehensive Cancer Centers of Nevada (CCCN) - Central Valley | Las Vegas | Nevada | 89169 | — |
| North Shore Hem Onc Associates | East Setauket | New York | 11733 | — |
| Memorial Sloan Kettering Cancer Center | New York | New York | 10022 | — |
| Atrium Health Levine Cancer Institute | Charlotte | North Carolina | 28204 | — |
| Levine Cancer Institute | Charlotte | North Carolina | 28204 | — |
| Duke Cancer Institute | Durham | North Carolina | 27710 | — |
| Ohio State University | Columbus | Ohio | 43210 | — |
| OSU, James Cancer Hospital | Columbus | Ohio | 43210 | — |
| Cancer Treatment Centers of America | Tulsa | Oklahoma | 74133 | — |
| Oregon Health & Science University | Portland | Oregon | 97239-3098 | — |
| Oregon Health & Science Univ | Portland | Oregon | 97239 | — |
| Mary Crowley Medical Research Center | Dallas | Texas | 75230 | — |
| Baylor Scott & White Health | Temple | Texas | 76508 | — |
| Virginia Cancer Specialists, PC | Fairfax | Virginia | 22031 | — |
| Virginia Oncology Associates - Hampton | Norfolk | Virginia | 23502 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 72 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT02568267, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Aug 25, 2026 · Synced Oct 17, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT02568267 live on ClinicalTrials.gov.