ClinicalTrials.gov record
A Study Comparing Upadacitinib (ABT-494) to Placebo and to Adalimumab in Adults With Rheumatoid Arthritis Who Are on a Stable Dose of Methotrexate and Who Have an Inadequate Response to Methotrexate
ClinicalTrials.gov ID: NCT02629159
Public ClinicalTrials.gov record NCT02629159. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
ClinicalTrials.gov public records Last synced May 5, 2026, 7:21 AM EDT
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 3, Randomized, Double-Blind Study Comparing Upadacitinib (ABT-494) to Placebo and to Adalimumab in Subjects With Moderately to Severely Active Rheumatoid Arthritis Who Are on a Stable Background of Methotrexate (MTX) and Who Have an Inadequate Response to MTX (MTX-IR)
Study identification
- NCT ID
- NCT02629159
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Lead sponsor
- AbbVie
- Industry
- Enrollment
- 1,629 participants
Conditions and interventions
Conditions
Interventions
- Adalimumab Drug
- Placebo for Adalimumab Drug
- Placebo for Upadacitinib Drug
- Upadacitinib Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Nov 30, 2015
- Primary completion
- Oct 26, 2017
- Completion
- Sep 29, 2027
- Last update posted
- Aug 4, 2025
2015 – 2027
United States locations
- U.S. sites
- 109
- U.S. states
- 28
- U.S. cities
- 86
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Achieve Clinical Research, LLC /ID# 143136 | Birmingham | Alabama | 35216 | — |
| AZ Arthritis and Rheum Assoc /ID# 143130 | Mesa | Arizona | 85202 | — |
| SunValley Arthritis Center, Lt /ID# 143123 | Peoria | Arizona | 85381 | — |
| Elite Clinical Studies, LLC /ID# 144881 | Phoenix | Arizona | 85018 | — |
| AZ Arthritis and Rheum Researc /ID# 143080 | Phoenix | Arizona | 85032-9306 | — |
| AZ Arthritis and Rheum Researc /ID# 143121 | Phoenix | Arizona | 85032-9306 | — |
| AZ Arthritis & Rheuma Research /ID# 143131 | Phoenix | Arizona | 85032 | — |
| Arizona Research Center, Inc. /ID# 144877 | Phoenix | Arizona | 85053-4061 | — |
| AZ Arthritis & Rheum Research /ID# 156093 | Sun City | Arizona | 85351 | — |
| University of Arizona Cancer Center - North Campus /ID# 143114 | Tucson | Arizona | 85719-1478 | — |
| Osteoporosis Medical Center /ID# 153935 | Beverly Hills | California | 90211 | — |
| T. Joseph Raoof, MD, Inc. /ID# 144884 | Encino | California | 91436 | — |
| Rheumatology Ctr of San Diego /ID# 153747 | Escondido | California | 92025 | — |
| C.V. Mehta MD, Med Corporation /ID# 143116 | Hemet | California | 92543 | — |
| Allergy and Rheum Med Clin /ID# 146083 | La Jolla | California | 92037 | — |
| Kotha and Kotha /ID# 161046 | La Mesa | California | 91942 | — |
| TriWest Research Associates- La Mesa /ID# 143115 | La Mesa | California | 91942 | — |
| Valerius Med Grp & Res Ctr /ID# 143120 | Los Alamitos | California | 90720-5402 | — |
| Discovery MM Services, Inc /ID# 163504 | Los Angeles | California | 11373 | — |
| Desert Medical Advances /ID# 143097 | Palm Desert | California | 92260 | — |
| Sierra Rheumatology /ID# 155672 | Roseville | California | 95661 | — |
| Robin K. Dore MD, Inc /ID# 143090 | Tustin | California | 92780 | — |
| Medvin Clinical Research /ID# 148362 | Whittier | California | 90606 | — |
| Arthritis Assoc & Osteo Ctr /ID# 143122 | Colorado Springs | Colorado | 80920 | — |
| Arthritis and Rheum Clin N. CO /ID# 156094 | Fort Collins | Colorado | 80528 | — |
| AARDS Research, Inc. /ID# 154190 | Aventura | Florida | 33180 | — |
| ZASA Clinical Research /ID# 143134 | Boynton Beach | Florida | 33472 | — |
| Clinical Res of West FL, Inc. /ID# 143112 | Clearwater | Florida | 33765 | — |
| International Medical Research /ID# 143132 | Daytona Beach | Florida | 32117 | — |
| Lakes Research, LLC /ID# 145630 | Miami | Florida | 33014 | — |
| FL Med Ctr and Research, Inc. /ID# 143081 | Miami | Florida | 33142 | — |
| Ctr Arthritis & Rheumatic Dise /ID# 143135 | Miami | Florida | 33173 | — |
| Precision Research Org, LLC /ID# 143092 | Miami Lakes | Florida | 33016-1501 | — |
| Advanced Clin Res of Orlando /ID# 154617 | Ocoee | Florida | 34761-4547 | — |
| Rheum Assoc of Central FL /ID# 145632 | Orlando | Florida | 32806 | — |
| Omega Research Consultants /ID# 145635 | Orlando | Florida | 32810 | — |
| HMD Research LLC /ID# 163292 | Orlando | Florida | 32819 | — |
| Arthritis Research of Florida /ID# 143125 | Palm Harbor | Florida | 34684-2672 | — |
| Arthritis Center, Inc. /ID# 145647 | Palm Harbor | Florida | 34684 | — |
| St. Anthony Comprehsve Res Ins /ID# 143095 | St. Petersburg | Florida | 33705 | — |
| Clinical Research West FL /ID# 148358 | Tampa | Florida | 33603 | — |
| SW FL Clin Res Ctr, Tampa, FL /ID# 143117 | Tampa | Florida | 33609 | — |
| BayCare Medical Group, Inc. /ID# 143085 | Tampa | Florida | 33614-7101 | — |
| Lovelace Scientific Resources /ID# 143106 | Venice | Florida | 34292 | — |
| Arthritis and Rheumatology /ID# 155668 | Atlanta | Georgia | 30342 | — |
| Arthritis Center of North GA /ID# 155258 | Gainesville | Georgia | 30501 | — |
| North Georgia Rheumatology Grp /ID# 147170 | Lawrenceville | Georgia | 30045 | — |
| Advanced Clinical Research /ID# 153090 | Meridian | Idaho | 83642 | — |
| Great Lakes Clinical Trials /ID# 148357 | Chicago | Illinois | 60640 | — |
| Arthritis Treatment Center /ID# 155260 | Frederick | Maryland | 21204 | — |
| The Center for Rheumatology & /ID# 151356 | Wheaton | Maryland | 20902 | — |
| Clinical Pharmacology Study Gr /ID# 143082 | Worcester | Massachusetts | 01605 | — |
| Advanced Rheumatology, PC /ID# 143118 | Lansing | Michigan | 48910 | — |
| Shores Rheumatology, PC /ID# 162977 | Saint Clair Shores | Michigan | 48081 | — |
| St. Luke's Hospital /ID# 156750 | Duluth | Minnesota | 55805 | — |
| North Mississippi Med Clinics /ID# 145636 | Tupelo | Mississippi | 38801 | — |
| Physician Res. Collaboration /ID# 143087 | Lincoln | Nebraska | 68516 | — |
| Quality Clinical Research Inc. /ID# 156394 | Omaha | Nebraska | 68114 | — |
| Atlantic Coast Research /ID# 148355 | Toms River | New Jersey | 08755 | — |
| Ocean Rheumatology, PA /ID# 143111 | Toms River | New Jersey | 08755 | — |
| Arthritis Rheumatic Back Disorder /ID# 143102 | Voorhees Township | New Jersey | 08043 | — |
| Albuquerque Clinical Trials, Inc /ID# 143083 | Albuquerque | New Mexico | 87102 | — |
| Arthritis and Osteo Assoc /ID# 143127 | Las Cruces | New Mexico | 88011 | — |
| St. Lawrence Health System /ID# 161619 | Potsdam | New York | 13676 | — |
| Joint & Muscle Research Instit /ID# 143119 | Charlotte | North Carolina | 28204 | — |
| DJL Clinical Research, PLLC /ID# 143101 | Charlotte | North Carolina | 28210-8508 | — |
| EmergeOrtho, P.A. /ID# 143100 | Durham | North Carolina | 27704 | — |
| Cape Fear Arthritis Care /ID# 148361 | Leland | North Carolina | 28451 | — |
| Coastal Carolina Health Care /ID# 148359 | New Bern | North Carolina | 28562 | — |
| Shanahan Rheuma & Immuno /ID# 145643 | Raleigh | North Carolina | 27617 | — |
| Clinical Research Solutions, LLC /ID# 154619 | Dayton | Ohio | 45409 | — |
| Arthritis Assoc of NW Ohio /ID# 143094 | Toledo | Ohio | 43606 | — |
| Healthcare Research Consultant /ID# 143129 | Tulsa | Oklahoma | 74135 | — |
| Altoona Ctr Clinical Res /ID# 143110 | Duncansville | Pennsylvania | 16635 | — |
| Clinical Research Ctr Reading /ID# 143133 | Wyomissing | Pennsylvania | 19610 | — |
| Columbia Arthritis Center /ID# 153730 | Columbia | South Carolina | 29204 | — |
| Innovative Clinical Research /ID# 145637 | Greenville | South Carolina | 29601 | — |
| Articularis Healthcare Group, Inc d/b/a Low Country Rheumatology /ID# 143091 | Summerville | South Carolina | 29486-7887 | — |
| Arthritis Associates, PLLC /ID# 155490 | Kingsport | Tennessee | 37660 | — |
| Rheumatology Consultants, PLLC /ID# 153731 | Knoxville | Tennessee | 37909 | — |
| Dr. Ramesh Gupta /ID# 143099 | Memphis | Tennessee | 38119 | — |
| Austin Regional Clinic /ID# 143084 | Austin | Texas | 78731 | — |
| Diagnostic Group Integrated He /ID# 148356 | Beaumont | Texas | 77701 | — |
| Arthritis Care and Diagnostic /ID# 150677 | Dallas | Texas | 75231 | — |
| Metroplex Clinical Research /ID# 145631 | Dallas | Texas | 75231 | — |
| Doctor's Hosp at Renaissance /ID# 154616 | Edinburg | Texas | 78539 | — |
| MedResearch Inc. /ID# 154618 | El Paso | Texas | 79935 | — |
| Accurate Clinical Management /ID# 145644 | Houston | Texas | 77004 | — |
| Accurate Clinical Research /ID# 145645 | Houston | Texas | 77034 | — |
| Rheumatology Clinic of Houston /ID# 150921 | Houston | Texas | 77065 | — |
| Houston Institute for Clin Res /ID# 144879 | Houston | Texas | 77074 | — |
| Pioneer Research Solutions, Inc. /ID# 145640 | Houston | Texas | 77098-5294 | — |
| Arthritis Consultants, P.A. /ID# 144880 | Killeen | Texas | 76549 | — |
| Arthritis & Osteoporosis Assoc /ID# 147364 | Lubbock | Texas | 79424 | — |
| P&I Clinical Research /ID# 161625 | Lufkin | Texas | 75904-3132 | — |
| SW Rheumatology Res. LLC /ID# 143126 | Mesquite | Texas | 75150 | — |
| Discovery MM Services, Inc. /ID# 162578 | Missouri City | Texas | 77459-4750 | — |
| Discovery MM Services, Inc. /ID# 163183 | Missouri City | Texas | 77459-4750 | — |
| Discovery MM Services, Inc. /ID# 163184 | Missouri City | Texas | 77459-4750 | — |
| Sun Research Institute /ID# 159539 | San Antonio | Texas | 78215 | — |
| Accurate Clinical Management /ID# 143089 | San Antonio | Texas | 78229 | — |
| Arthritis & Osteo Ctr of S. TX /ID# 143103 | San Antonio | Texas | 78232 | — |
| DM Clinical Research /ID# 151357 | Tomball | Texas | 77375 | — |
| Arthritis Clinic of N. VA, P.C /ID# 143109 | Arlington | Virginia | 22205 | — |
| Ctr for Arth and Rheum Disease /ID# 143113 | Chesapeake | Virginia | 23320 | — |
| Arthritis Northwest, PLLC /ID# 143088 | Spokane | Washington | 99204 | — |
| The Vancouver Clinic, INC. PS /ID# 143107 | Vancouver | Washington | 98664 | — |
| West Virginia Research Inst /ID# 153088 | South Charleston | West Virginia | 25309 | — |
| Rheumatology and Immunotherapy Center /ID# 145646 | Franklin | Wisconsin | 53132 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 261 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT02629159, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Aug 4, 2025 · Synced May 5, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT02629159 live on ClinicalTrials.gov.