ClinicalTrials.gov record
A Study Comparing Upadacitinib (ABT-494) to Placebo and to Adalimumab in Adults With Rheumatoid Arthritis Who Are on a Stable Dose of Methotrexate and Who Have an Inadequate Response to Methotrexate
ClinicalTrials.gov ID: NCT02629159
Public ClinicalTrials.gov record NCT02629159. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 3, Randomized, Double-Blind Study Comparing Upadacitinib (ABT-494) to Placebo and to Adalimumab in Subjects With Moderately to Severely Active Rheumatoid Arthritis Who Are on a Stable Background of Methotrexate (MTX) and Who Have an Inadequate Response to MTX (MTX-IR)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The purpose of this study was to assess efficacy, including inhibition of radiographic progression, and safety with upadacitinib versus placebo and versus an active comparator, adalimumab, in adults with with moderately to severely active rheumatoid arthritis (RA) who are on a stable background of methotrexate (MTX and who have an inadequate response to MTX.
Study identification
- NCT ID
- NCT02629159
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 1,629 participants
Conditions and interventions
Conditions
Interventions
- Placebo for Adalimumab Drug
- Adalimumab Drug
- Placebo for Upadacitinib Drug
- Upadacitinib Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Nov 30, 2015
- Primary completion
- Oct 26, 2017
- Completion
- Sep 29, 2027
- Last update posted
- Aug 4, 2025
2015 – 2027
United States locations
- U.S. sites
- 109
- U.S. states
- 28
- U.S. cities
- 86
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Achieve Clinical Research, LLC /ID# 143136 | Birmingham | Alabama | 35216 | — |
| AZ Arthritis and Rheum Assoc /ID# 143130 | Mesa | Arizona | 85202 | — |
| SunValley Arthritis Center, Lt /ID# 143123 | Peoria | Arizona | 85381 | — |
| Elite Clinical Studies, LLC /ID# 144881 | Phoenix | Arizona | 85018 | — |
| AZ Arthritis and Rheum Researc /ID# 143080 | Phoenix | Arizona | 85032-9306 | — |
| AZ Arthritis and Rheum Researc /ID# 143121 | Phoenix | Arizona | 85032-9306 | — |
| AZ Arthritis & Rheuma Research /ID# 143131 | Phoenix | Arizona | 85032 | — |
| Arizona Research Center, Inc. /ID# 144877 | Phoenix | Arizona | 85053-4061 | — |
| AZ Arthritis & Rheum Research /ID# 156093 | Sun City | Arizona | 85351 | — |
| University of Arizona Cancer Center - North Campus /ID# 143114 | Tucson | Arizona | 85719-1478 | — |
| Osteoporosis Medical Center /ID# 153935 | Beverly Hills | California | 90211 | — |
| T. Joseph Raoof, MD, Inc. /ID# 144884 | Encino | California | 91436 | — |
| Rheumatology Ctr of San Diego /ID# 153747 | Escondido | California | 92025 | — |
| C.V. Mehta MD, Med Corporation /ID# 143116 | Hemet | California | 92543 | — |
| Allergy and Rheum Med Clin /ID# 146083 | La Jolla | California | 92037 | — |
| Kotha and Kotha /ID# 161046 | La Mesa | California | 91942 | — |
| TriWest Research Associates- La Mesa /ID# 143115 | La Mesa | California | 91942 | — |
| Valerius Med Grp & Res Ctr /ID# 143120 | Los Alamitos | California | 90720-5402 | — |
| Discovery MM Services, Inc /ID# 163504 | Los Angeles | California | 11373 | — |
| Desert Medical Advances /ID# 143097 | Palm Desert | California | 92260 | — |
| Sierra Rheumatology /ID# 155672 | Roseville | California | 95661 | — |
| Robin K. Dore MD, Inc /ID# 143090 | Tustin | California | 92780 | — |
| Medvin Clinical Research /ID# 148362 | Whittier | California | 90606 | — |
| Arthritis Assoc & Osteo Ctr /ID# 143122 | Colorado Springs | Colorado | 80920 | — |
| Arthritis and Rheum Clin N. CO /ID# 156094 | Fort Collins | Colorado | 80528 | — |
| AARDS Research, Inc. /ID# 154190 | Aventura | Florida | 33180 | — |
| ZASA Clinical Research /ID# 143134 | Boynton Beach | Florida | 33472 | — |
| Clinical Res of West FL, Inc. /ID# 143112 | Clearwater | Florida | 33765 | — |
| International Medical Research /ID# 143132 | Daytona Beach | Florida | 32117 | — |
| Lakes Research, LLC /ID# 145630 | Miami | Florida | 33014 | — |
| FL Med Ctr and Research, Inc. /ID# 143081 | Miami | Florida | 33142 | — |
| Ctr Arthritis & Rheumatic Dise /ID# 143135 | Miami | Florida | 33173 | — |
| Precision Research Org, LLC /ID# 143092 | Miami Lakes | Florida | 33016-1501 | — |
| Advanced Clin Res of Orlando /ID# 154617 | Ocoee | Florida | 34761-4547 | — |
| Rheum Assoc of Central FL /ID# 145632 | Orlando | Florida | 32806 | — |
| Omega Research Consultants /ID# 145635 | Orlando | Florida | 32810 | — |
| HMD Research LLC /ID# 163292 | Orlando | Florida | 32819 | — |
| Arthritis Research of Florida /ID# 143125 | Palm Harbor | Florida | 34684-2672 | — |
| Arthritis Center, Inc. /ID# 145647 | Palm Harbor | Florida | 34684 | — |
| St. Anthony Comprehsve Res Ins /ID# 143095 | St. Petersburg | Florida | 33705 | — |
| Clinical Research West FL /ID# 148358 | Tampa | Florida | 33603 | — |
| SW FL Clin Res Ctr, Tampa, FL /ID# 143117 | Tampa | Florida | 33609 | — |
| BayCare Medical Group, Inc. /ID# 143085 | Tampa | Florida | 33614-7101 | — |
| Lovelace Scientific Resources /ID# 143106 | Venice | Florida | 34292 | — |
| Arthritis and Rheumatology /ID# 155668 | Atlanta | Georgia | 30342 | — |
| Arthritis Center of North GA /ID# 155258 | Gainesville | Georgia | 30501 | — |
| North Georgia Rheumatology Grp /ID# 147170 | Lawrenceville | Georgia | 30045 | — |
| Advanced Clinical Research /ID# 153090 | Meridian | Idaho | 83642 | — |
| Great Lakes Clinical Trials /ID# 148357 | Chicago | Illinois | 60640 | — |
| Arthritis Treatment Center /ID# 155260 | Frederick | Maryland | 21204 | — |
| The Center for Rheumatology & /ID# 151356 | Wheaton | Maryland | 20902 | — |
| Clinical Pharmacology Study Gr /ID# 143082 | Worcester | Massachusetts | 01605 | — |
| Advanced Rheumatology, PC /ID# 143118 | Lansing | Michigan | 48910 | — |
| Shores Rheumatology, PC /ID# 162977 | Saint Clair Shores | Michigan | 48081 | — |
| St. Luke's Hospital /ID# 156750 | Duluth | Minnesota | 55805 | — |
| North Mississippi Med Clinics /ID# 145636 | Tupelo | Mississippi | 38801 | — |
| Physician Res. Collaboration /ID# 143087 | Lincoln | Nebraska | 68516 | — |
| Quality Clinical Research Inc. /ID# 156394 | Omaha | Nebraska | 68114 | — |
| Atlantic Coast Research /ID# 148355 | Toms River | New Jersey | 08755 | — |
| Ocean Rheumatology, PA /ID# 143111 | Toms River | New Jersey | 08755 | — |
| Arthritis Rheumatic Back Disorder /ID# 143102 | Voorhees Township | New Jersey | 08043 | — |
| Albuquerque Clinical Trials, Inc /ID# 143083 | Albuquerque | New Mexico | 87102 | — |
| Arthritis and Osteo Assoc /ID# 143127 | Las Cruces | New Mexico | 88011 | — |
| St. Lawrence Health System /ID# 161619 | Potsdam | New York | 13676 | — |
| Joint & Muscle Research Instit /ID# 143119 | Charlotte | North Carolina | 28204 | — |
| DJL Clinical Research, PLLC /ID# 143101 | Charlotte | North Carolina | 28210-8508 | — |
| EmergeOrtho, P.A. /ID# 143100 | Durham | North Carolina | 27704 | — |
| Cape Fear Arthritis Care /ID# 148361 | Leland | North Carolina | 28451 | — |
| Coastal Carolina Health Care /ID# 148359 | New Bern | North Carolina | 28562 | — |
| Shanahan Rheuma & Immuno /ID# 145643 | Raleigh | North Carolina | 27617 | — |
| Clinical Research Solutions, LLC /ID# 154619 | Dayton | Ohio | 45409 | — |
| Arthritis Assoc of NW Ohio /ID# 143094 | Toledo | Ohio | 43606 | — |
| Healthcare Research Consultant /ID# 143129 | Tulsa | Oklahoma | 74135 | — |
| Altoona Ctr Clinical Res /ID# 143110 | Duncansville | Pennsylvania | 16635 | — |
| Clinical Research Ctr Reading /ID# 143133 | Wyomissing | Pennsylvania | 19610 | — |
| Columbia Arthritis Center /ID# 153730 | Columbia | South Carolina | 29204 | — |
| Innovative Clinical Research /ID# 145637 | Greenville | South Carolina | 29601 | — |
| Articularis Healthcare Group, Inc d/b/a Low Country Rheumatology /ID# 143091 | Summerville | South Carolina | 29486-7887 | — |
| Arthritis Associates, PLLC /ID# 155490 | Kingsport | Tennessee | 37660 | — |
| Rheumatology Consultants, PLLC /ID# 153731 | Knoxville | Tennessee | 37909 | — |
| Dr. Ramesh Gupta /ID# 143099 | Memphis | Tennessee | 38119 | — |
| Austin Regional Clinic /ID# 143084 | Austin | Texas | 78731 | — |
| Diagnostic Group Integrated He /ID# 148356 | Beaumont | Texas | 77701 | — |
| Arthritis Care and Diagnostic /ID# 150677 | Dallas | Texas | 75231 | — |
| Metroplex Clinical Research /ID# 145631 | Dallas | Texas | 75231 | — |
| Doctor's Hosp at Renaissance /ID# 154616 | Edinburg | Texas | 78539 | — |
| MedResearch Inc. /ID# 154618 | El Paso | Texas | 79935 | — |
| Accurate Clinical Management /ID# 145644 | Houston | Texas | 77004 | — |
| Accurate Clinical Research /ID# 145645 | Houston | Texas | 77034 | — |
| Rheumatology Clinic of Houston /ID# 150921 | Houston | Texas | 77065 | — |
| Houston Institute for Clin Res /ID# 144879 | Houston | Texas | 77074 | — |
| Pioneer Research Solutions, Inc. /ID# 145640 | Houston | Texas | 77098-5294 | — |
| Arthritis Consultants, P.A. /ID# 144880 | Killeen | Texas | 76549 | — |
| Arthritis & Osteoporosis Assoc /ID# 147364 | Lubbock | Texas | 79424 | — |
| P&I Clinical Research /ID# 161625 | Lufkin | Texas | 75904-3132 | — |
| SW Rheumatology Res. LLC /ID# 143126 | Mesquite | Texas | 75150 | — |
| Discovery MM Services, Inc. /ID# 162578 | Missouri City | Texas | 77459-4750 | — |
| Discovery MM Services, Inc. /ID# 163183 | Missouri City | Texas | 77459-4750 | — |
| Discovery MM Services, Inc. /ID# 163184 | Missouri City | Texas | 77459-4750 | — |
| Sun Research Institute /ID# 159539 | San Antonio | Texas | 78215 | — |
| Accurate Clinical Management /ID# 143089 | San Antonio | Texas | 78229 | — |
| Arthritis & Osteo Ctr of S. TX /ID# 143103 | San Antonio | Texas | 78232 | — |
| DM Clinical Research /ID# 151357 | Tomball | Texas | 77375 | — |
| Arthritis Clinic of N. VA, P.C /ID# 143109 | Arlington | Virginia | 22205 | — |
| Ctr for Arth and Rheum Disease /ID# 143113 | Chesapeake | Virginia | 23320 | — |
| Arthritis Northwest, PLLC /ID# 143088 | Spokane | Washington | 99204 | — |
| The Vancouver Clinic, INC. PS /ID# 143107 | Vancouver | Washington | 98664 | — |
| West Virginia Research Inst /ID# 153088 | South Charleston | West Virginia | 25309 | — |
| Rheumatology and Immunotherapy Center /ID# 145646 | Franklin | Wisconsin | 53132 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 261 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT02629159, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Aug 4, 2025 · Synced Sep 24, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete protocol, eligibility criteria, and contact information for NCT02629159 live on ClinicalTrials.gov.