A Study of Mirvetuximab Soravtansine vs. Investigator's Choice of Chemotherapy in Women With Folate Receptor (FR) Alpha Positive Advanced Epithelial Ovarian Cancer (EOC), Primary Peritoneal or Fallopian Tube Cancer
Public ClinicalTrials.gov record NCT02631876. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
FORWARD I: A Randomized, Open Label Phase 3 Study to Evaluate the Safety and Efficacy of Mirvetuximab Soravtansine (IMGN853) Versus Investigator's Choice of Chemotherapy in Women With Folate Receptor Alpha Positive Advanced Epithelial Ovarian Cancer, Primary Peritoneal Cancer or Fallopian Tube Cancer
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This is a Phase 3, open label, randomized study designed to compare the safety and efficacy of mirvetuximab soravtansine to that of selected single-agent chemotherapy (Investigator's choice) in women with platinum-resistant FR-alpha positive advanced EOC, primary peritoneal cancer and/or fallopian tube cancer.
Study identification
- NCT ID
- NCT02631876
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 366 participants
Conditions and interventions
Conditions
Interventions
- Mirvetuximab soravtansine Drug
- Paclitaxel Drug
- Pegylated liposomal doxorubicin Drug
- Topotecan Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- Female
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Mar 2, 2016 (Actual)
- Primary completion
- Jan 2019 (Actual)
- Completion
- Jan 2020 (Actual)
- Last update posted
- Oct 14, 2020
2016 – 2020
United States locations
- U.S. sites
- 53
- U.S. states
- 28
- U.S. cities
- 47
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| University of Alabama at Birmingham | Birmingham | Alabama | 35294 | — |
| Arizona Oncology Associates, PC - HAL | Tempe | Arizona | 85284 | — |
| Arizona Oncology Associates, PC - HOPE | Tucson | Arizona | 85711 | — |
| UCLA Women's Health Clinical Research Unit - OBGYN | Los Angeles | California | 90095 | — |
| University of California San Diego Medical Center | San Diego | California | 92093 | — |
| California Pacific Medical Center | San Francisco | California | 94118 | — |
| Kaiser Permanente Medical Center | Vallejo | California | 94589 | — |
| Yale University School of Medicine | New Haven | Connecticut | 06520 | — |
| Norwalk Hospital/WCHN | Norwalk | Connecticut | 06856 | — |
| Florida State University College of Medicine | Sarasota | Florida | 34239 | — |
| Georgia Regents University (GRU)-Medical College of Georgia (MCG) - Cancer Center | Augusta | Georgia | 30912 | — |
| Rush University Medical Center | Chicago | Illinois | 60629 | — |
| Sudarshan Sharma LTD | Hinsdale | Illinois | 60521 | — |
| Community Health Network, Inc. | Indianapolis | Indiana | 46184 | — |
| Indiana University School of Medicine | Indianapolis | Indiana | 46202 | — |
| Norton Cancer Institute | Louisville | Kentucky | 40241 | — |
| Women's Cancer Care | Covington | Louisiana | 70433 | — |
| Ochsner Clinic Foundation | New Orleans | Louisiana | 70121 | — |
| WK Physician Network Clinical Research | Shreveport | Louisiana | 71101 | — |
| Holy Cross Hospital | Silver Spring | Maryland | 20902 | — |
| Massachusetts General Hospital | Boston | Massachusetts | 02114 | — |
| Dana-Farber Cancer Institute | Boston | Massachusetts | 02215 | — |
| University of Massachusetts Memorial Medical Center | Worcester | Massachusetts | 01605 | — |
| Karmanos Cancer Institute | Detroit | Michigan | 48201 | — |
| Henry Ford Hospital | Detroit | Michigan | 48202 | — |
| Mercy Women's Oncology | Springfield | Missouri | 65804 | — |
| Center of Hope | Reno | Nevada | 89502 | — |
| Dartmouth-Hitchcock Medical Center | Lebanon | New Hampshire | 03756 | — |
| MD Anderson Cancer Center - Cooper Health | Camden | New Jersey | 08103 | — |
| Overlook Medical Center | Summit | New Jersey | 07901 | — |
| The University of New Mexico Comprehensive Cancer Center - Memorial Medical Center | Albuquerque | New Mexico | 87131 | — |
| Laura and Isaac Perlmutter Cancer Center at NYU Langone | New York | New York | 10016 | — |
| Icahn School of Medicine at Mount Sinai | New York | New York | 10029 | — |
| Memorial Sloan Kettering Cancer Center and (MSK Monmouth) and ( MSK Westchester) | New York | New York | 10065 | — |
| Levine Cancer Institute - Carolinas Medical Center | Charlotte | North Carolina | 28204 | — |
| University of Cincinnati Medical Center | Cincinnati | Ohio | 45267 | — |
| Fairview Hospital, Moll Pavilion Cancer Center | Cleveland | Ohio | 44111 | — |
| Cleveland Clinic | Cleveland | Ohio | 44195 | — |
| OSU Wexner Medical Center | Columbus | Ohio | 43210 | — |
| Hillcrest Hospital | Mayfield | Ohio | 44124 | — |
| University of Oklahoma Health Sciences Center | Oklahoma City | Oklahoma | 73104 | — |
| Oklahoma Cancer Specialists and Research Institute, LLC | Tulsa | Oklahoma | 74146 | — |
| University of Pennsylvania | Philadelphia | Pennsylvania | 19104 | — |
| Magee - Womens Hospital of UPMC | Pittsburgh | Pennsylvania | 15213 | — |
| Women & Infants of Rhode Island | Providence | Rhode Island | 02905 | — |
| Hollings Cancer Center | Charleston | South Carolina | 29425 | — |
| Texas Oncology-Austin Central | Austin | Texas | 78731 | — |
| University of Texas Southwestern Medical Center | Dallas | Texas | 75390 | — |
| Texas Oncology - Fort Worth | Fort Worth | Texas | 76104 | — |
| Texas Oncology - The Woodlands, Gynecologic Oncology | The Woodlands | Texas | 77380 | — |
| Texas Oncology-Tyler | Tyler | Texas | 75702 | — |
| Kadlec Clinic Hematology & Oncology | Kennewick | Washington | 99336 | — |
| Froedtert and Medical College of Wisconsin | Milwaukee | Wisconsin | 53226 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 78 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT02631876, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Oct 14, 2020 · Synced Oct 21, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT02631876 live on ClinicalTrials.gov.