ClinicalTrials.gov record
SPI-2012 vs Pegfilgrastim in the Management of Neutropenia in Participants With Breast Cancer With Docetaxel and Cyclophosphamide (ADVANCE)
ClinicalTrials.gov ID: NCT02643420
Public ClinicalTrials.gov record NCT02643420. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
RAnDomized Trial of SPI-2012 Versus Pegfilgrastim in the Management of Chemotherapy Induced Neutropenia in Breast CANCEr Patients Receiving Docetaxel and Cyclophosphamide (TC) (ADVANCE)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The purpose of this study was to compare the efficacy of a single dose of SPI-2012 versus pegfilgrastim in participants with early-stage breast cancer receiving docetaxel and cyclophosphamide (TC), as measured by the duration of severe neutropenia (DSN) in Cycle 1.
Study identification
- NCT ID
- NCT02643420
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 406 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jan 18, 2016
- Primary completion
- Jan 23, 2018
- Completion
- Oct 30, 2018
- Last update posted
- Mar 1, 2022
2016 – 2018
United States locations
- U.S. sites
- 76
- U.S. states
- 31
- U.S. cities
- 74
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Arizona Center for Cancer Care | Glendale | Arizona | 85306 | — |
| Arizona Clinical Research Center/ ACRC | Tucson | Arizona | 85715 | — |
| Yuma Regional Medical Center | Yuma | Arizona | 85364 | — |
| Genesis Cancer Center | Hot Springs | Arkansas | 71913 | — |
| NEA Baptist Clinic | Fowler Family Center for Cancer Care | Jonesboro | Arkansas | 72401 | — |
| Pacific Cancer Medical Center, Inc. | Anaheim | California | 92801 | — |
| CBCC Global Research, Inc. at Comprehensive Blood and Cancer Center | Bakersfield | California | 93309 | — |
| Alta Bates Summit Medical Center | Berkeley | California | 94704 | — |
| Precision Research Institute, LLC | Chula Vista | California | 91910 | — |
| Compassionate Cancer Care Medical Group, Inc. | Corona | California | 92879 | — |
| Compassionate Care Research Group, Inc. | Fountain Valley | California | 92708 | — |
| Long Beach Memorial Medical Center | Long Beach | California | 90806 | — |
| Pacific Shores Medical Group | Long Beach | California | 90813 | — |
| Ventura County Hematology-Oncology Specialists | Oxnard | California | 93030 | — |
| Valley Medical Oncology Consultants | Pleasanton | California | 94588 | — |
| Emad Ibrahim, MD, Inc. | Redlands | California | 92373 | — |
| Compassionate Cancer Care Medical Group, Inc | Riverside | California | 92501 | — |
| St Joseph Heritage Healthcare Institution | Santa Rosa | California | 95403 | — |
| Wellness Oncology Hematology | West Hills | California | 91307 | — |
| Oncology Institute of Hope and Innovation | Whittier | California | 90603 | — |
| Omega Research Consultants LLC | DeBary | Florida | 32713 | — |
| Pasco Pinellas Cancer Center | Holiday | Florida | 34691 | — |
| AMPM Research Clinic | Miami | Florida | 33133 | — |
| Lakes Research, LLC | Miami Lakes | Florida | 33014 | — |
| Mid Florida Hematology and Oncology Centers | Orange City | Florida | 32763 | — |
| Florida Cancer Research Institute | Plantation | Florida | 33324 | — |
| Bond Clinic, P.A. | Winter Haven | Florida | 33881 | — |
| John B Amos Cancer Center | Columbus | Georgia | 31904 | — |
| Dwight D. Eisenhower Army Medical Center | Fort Gordon | Georgia | 30905 | — |
| Memorial Health University Medical Center | Savannah | Georgia | 31404 | — |
| Saint Alphonsus Regional Medical Center | Boise | Idaho | 83706 | — |
| Clintell, Inc/Swedish Covenant Hospital | Chicago | Illinois | 60625 | — |
| Joliet Oncology Hematology Associates | Joliet | Illinois | 60435 | — |
| Oncology Specialists, SC | Park Ridge | Illinois | 60068 | — |
| Swedish American Cancer Center | Rockford | Illinois | 61114 | — |
| Carle Cancer Center | Urbana | Illinois | 61801 | — |
| Franciscan St. Francis Health | Indianapolis | Indiana | 46237 | — |
| Floyd Memorial Cancer Center of Indiana | New Albany | Indiana | 47150 | — |
| Northern Indiana Cancer Research Consortium | Westville | Indiana | 46391 | — |
| Ashland-Bellefonte Cancer Center | Ashland | Kentucky | 41101 | — |
| West Ky Hematology & Oncology Group, PSC | Paducah | Kentucky | 42003 | — |
| Pontchartrain Cancer Center | Covington | Louisiana | 70433 | — |
| Highland Clinic | Shreveport | Louisiana | 71105 | — |
| Penobscot Bay Medical Center | Rockport | Maine | 04856 | — |
| RCCA MD LLC/The Center for Cancer and Blood Disorders | Bethesda | Maryland | 20817 | — |
| Reliant Medical Group | Worcester | Massachusetts | 01608v | — |
| Quest Research Institute | Royal Oak | Michigan | 48073 | — |
| Forrest General Hospital | Hattiesburg | Mississippi | 39401 | — |
| Freeman Health Systems | Joplin | Missouri | 64804 | — |
| St. Vincent Frontier Cancer Center | Billings | Montana | 59102 | — |
| Saint Francis Cancer Treatment Center | Grand Island | Nebraska | 68803 | — |
| Southeast Nebraska Hematology & Oncology Consultants, PC | Lincoln | Nebraska | 68510 | — |
| New Jersey Hematology Oncology Associates | Brick | New Jersey | 08724 | — |
| North Shore Hematology Oncology Associates | East Setauket | New York | 11733 | — |
| Waverly Hematology Oncology | Cary | North Carolina | 27518 | — |
| Aultman Hospital | Canton | Ohio | 44710 | — |
| Gabrail Cancer Center Research | Canton | Ohio | 44718 | — |
| The Lindner Research Center at the Christ Hospital | Cincinnati | Ohio | 45219 | — |
| Mercy Health Youngstown LLC DBA | Youngstown | Ohio | 44504 44501 | — |
| Good Samaritan Hospital Corvallis | Corvallis | Oregon | 97330 | — |
| University of Pittsburgh Medical Center (UPMC) | Pittsburgh | Pennsylvania | 15232 | — |
| Associates in Hematology and Oncology, PC | Upland | Pennsylvania | 19013 | — |
| AnMed Health Cancer Center | Anderson | South Carolina | 29621 | — |
| Bon Secours Saint Francis Cancer | Greenville | South Carolina | 29607 | — |
| Carolina Blood and Cancer Care | Rock Hill | South Carolina | 29732 | — |
| Cookeville Regional Medical Center | Cookeville | Tennessee | 38501 | — |
| The West Clinic, PC, d/b/a West Cancer Center | Germantown | Tennessee | 38138 | — |
| CHI St. Joseph Health Cancer Center | Bryan | Texas | 77802 | — |
| Texas Oncology -Methodist Dallas Cancer Center | Dallas | Texas | 75203 | — |
| Oncology Consultants | Houston | Texas | 77030 | — |
| Texas Oncology, PA | McAllen | Texas | 78503 | — |
| Methodist Richardson Medical Center- Cancer Center | Richardson | Texas | 75082 | — |
| Northern Utah Associates | Ogden | Utah | 84403 | — |
| Delta Oncology Associates | Portsmouth | Virginia | 23704 | — |
| Northwest Medical Specialties, PLLC | Tacoma | Washington | 98405 | — |
| West Virginia University | Morgantown | West Virginia | 26506 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 5 non-U.S. sites.
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About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT02643420, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Mar 1, 2022 · Synced Sep 9, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT02643420 live on ClinicalTrials.gov.