A Trial of PF-07901800 (TTI-621) for Patients With Hematologic Malignancies and Selected Solid Tumors
Public ClinicalTrials.gov record NCT02663518. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 1a/1b Dose Escalation and Expansion Trial of TTI-621, a Novel Biologic Targeting CD47, in Subjects With Relapsed or Refractory Hematologic Malignancies and Selected Solid Tumors
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
Multicenter, open-label, phase 1a/1b trial of PF-07901800 (TTI-621) in subjects with relapsed or refractory hematologic malignancies and selected solid tumors.
Study identification
- NCT ID
- NCT02663518
- Recruitment status
- Terminated
- Study type
- Interventional
- Phase
- Phase 1
- Enrollment
- 249 participants
Conditions and interventions
Conditions
Interventions
- PF-0791800 (TTI-621) Drug
- PF-07901800 (TTI-621) plus Rituximab Drug
- PF-07901800 (TTI-621) plus Nivolumab Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jan 28, 2016 (Actual)
- Primary completion
- Nov 23, 2022 (Actual)
- Completion
- Nov 23, 2022 (Actual)
- Last update posted
- May 10, 2024
2016 – 2022
United States locations
- U.S. sites
- 47
- U.S. states
- 13
- U.S. cities
- 18
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| City of Hope National Medical Center | Duarte | California | 91010 | — |
| City of Hope | Duarte | California | 91010 | — |
| Freidenrich Center for Translational Research (CTRU) | Palo Alto | California | 94304 | — |
| Stanford Cancer Institute | Palo Alto | California | 94304 | — |
| Colorado Blood Cancer Institute | Denver | Colorado | 80218 | — |
| Presbyterian/St.Luke's Medical Center | Denver | Colorado | 80218 | — |
| Mayo Clinic Jacksonville | Jacksonville | Florida | 32224 | — |
| Mayo Clinic | Jacksonville | Florida | 32224 | — |
| Moffitt Cancer Center Richard M Schulze Family Foundation Outpatient Center at McKinley Campus | Tampa | Florida | 33612 | — |
| Moffitt Cancer Center | Tampa | Florida | 33612 | — |
| Covance Biorepository | Greenfield | Indiana | 46140 | — |
| Mayo Clinic | Rochester | Minnesota | 55905 | — |
| Hackensack Meridian Health John Theurer Cancer Center | Hackensack | New Jersey | 07601 | — |
| Hackensack UMC | Hackensack | New Jersey | 07601 | — |
| The John Theurer Cancer Center at Hackensack UMC | Hackensack | New Jersey | 07601 | — |
| Memorial Sloan Kettering Cancer Center- Monmouth | Middletown | New Jersey | 07748 | — |
| Memorial Sloan Kettering Cancer Center Westchester | Harrison | New York | 10604 | — |
| Laura and Isaac Perlmutter Cancer Center at NYU Langone Health | New York | New York | 10016 | — |
| Laura and Isaac Perlmutter Cancer Center at NYU Langone | New York | New York | 10016 | — |
| NYU Investigational Pharmacy | New York | New York | 10016 | — |
| NYU Langone Health (Tisch Hospital) | New York | New York | 10016 | — |
| Memorial Sloan Kettering Cancer Center-Clinical Trails Office | New York | New York | 10017 | — |
| Columbia Univeristy | New York | New York | 10019 | — |
| Memorial Sloan Kettering Cancer Center - David H. Koch Center for Cancer Care | New York | New York | 10021 | — |
| Memorial Sloan Kettering Cancer Center Rockefeller Outpatient Pavillion | New York | New York | 10022 | — |
| Columbia University Medical Center. | New York | New York | 10032 | — |
| Memorial Sloan Kettering Cancer Center | New York | New York | 10065 | — |
| Cleveland Clinic Taussig Cancer Center | Cleveland | Ohio | 44195 | — |
| Cleveland Clinic | Cleveland | Ohio | 44195 | — |
| Oregon Health & Science University-Research Pharmacy Services | Portland | Oregon | 97239 | — |
| Oregon Health & Science University | Portland | Oregon | 97239 | — |
| Oregon Health and Sciences University | Portland | Oregon | 97239 | — |
| University of Pittsburgh Medical Center Presbyterian Shadyside | Pittsburgh | Pennsylvania | 15213 | — |
| University of Pittsburgh Medical Center | Pittsburgh | Pennsylvania | 15237 | — |
| Centennial Medical Center | Nashville | Tennessee | 37203 | — |
| Sarah Cannon Research Institute (Pharmacy) | Nashville | Tennessee | 37203 | — |
| Tennessee Oncology PLLC | Nashville | Tennessee | 37203 | — |
| Tennessee Oncology, PLLC | Nashville | Tennessee | 37203 | — |
| Tennessee Oncology | Nashville | Tennessee | 37203 | — |
| Myriad RMB Inc | Austin | Texas | 78759 | — |
| The University of Texas MD Anderson Cancer Center | Houston | Texas | 77030 | — |
| University of Texas MD Anderson Cancer Center, Cancer Prevention Center | Houston | Texas | 77030 | — |
| University of Texas MD Anderson Cancer Center, Melanoma and Skin Clinic | Houston | Texas | 77030 | — |
| University of Texas MD Anderson Cancer Center | Houston | Texas | 77030 | — |
| Seattle Cancer Care Alliance | Seattle | Washington | 98109 | — |
| University of Washington - Seattle Cancer Care Alliance | Seattle | Washington | 98109 | — |
| University of Washington Medical Center | Seattle | Washington | 98195 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 4 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT02663518, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted May 10, 2024 · Synced Oct 24, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT02663518 live on ClinicalTrials.gov.