A Study Evaluating the Efficacy and Safety of Crenezumab Versus Placebo in Participants With Prodromal to Mild Alzheimer's Disease (AD).
Public ClinicalTrials.gov record NCT02670083. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase III, Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, Efficacy And Safety Study of Crenezumab in Patients With Prodromal to Mild Alzheimer's Disease.
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This randomized, double-blind, placebo-controlled, parallel group study will evaluate the efficacy and safety of crenezumab versus placebo in participants with prodromal to mild AD. Participants will be randomized 1:1 to receive either intravenous (IV) infusion of crenezumab or placebo every 4 weeks (Q4W) for 100 weeks. The final efficacy and safety assessment will be performed 52 weeks after the last crenezumab dose. Participants will then have the option to enter the Open Label Extension (OLE) study if eligible. Participants who do not enter the OLE study will have additional follow-up visits at 16 and 52 weeks after the last dose, primarily for safety and also for limited efficacy assessments.
Study identification
- NCT ID
- NCT02670083
- Recruitment status
- Terminated
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 813 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 50 Years to 85 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Mar 22, 2016 (Actual)
- Primary completion
- May 31, 2019 (Actual)
- Completion
- May 31, 2019 (Actual)
- Last update posted
- Jul 16, 2020
2016 – 2019
United States locations
- U.S. sites
- 66
- U.S. states
- 21
- U.S. cities
- 59
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Banner Alzheimer's Institute | Phoenix | Arizona | 85006 | — |
| Pharmacology Research Inst | Encino | California | 91316 | — |
| Collaborative Neuroscience Network Inc. | Long Beach | California | 90502 | — |
| Alliance for Wellness, dba Alliance for Research | Long Beach | California | 90807 | — |
| Pharmacology Research Institute | Los Alamitos | California | 90720 | — |
| USC Keck School Of Medicine | Los Angeles | California | 90033 | — |
| UCLA Medical Center, Department of Neurology | Los Angeles | California | 90095 | — |
| Pharmacology Research Inst | Newport Beach | California | 92660 | — |
| Shankle Clinic | Newport Beach | California | 92663 | — |
| Stanford Univ Medical Center | Palo Alto | California | 94304 | — |
| Anderson Clinical Research, Inc. | Redlands | California | 92374 | — |
| University of California, Davis; Alzheimers Disease Center, Department of Neurology | Sacramento | California | 95817 | — |
| UCSF - Memory and Aging Center | San Francisco | California | 94158 | — |
| Neurological Research Inst | Santa Monica | California | 90404 | — |
| North Bay Neuro Science Institute | Sebastopol | California | 95472 | — |
| Associated Neurologists PC - Danbury | Danbury | Connecticut | 06810 | — |
| Institute for Neurodegenerative Disorders | New Haven | Connecticut | 06510 | — |
| Yale University School Of Medicine | New Haven | Connecticut | 06510 | — |
| Research Center for Clinical Studies, Inc. | Norwalk | Connecticut | 06851 | — |
| Bradenton Research Center | Bradenton | Florida | 34205 | — |
| Quantum Laboratories | Deerfield Beach | Florida | 33064 | — |
| Brain Matters Research, Inc. | Delray Beach | Florida | 33445 | — |
| Galiz Research, LLC | Hialeah | Florida | 33016 | — |
| Jacksonville Center For Clinical Research | Jacksonville | Florida | 32216 | — |
| Alzheimer's Research and Treatment Center | Lake Worth | Florida | 33414 | — |
| Merritt - Island Medical Research | Merritt Island | Florida | 32952 | — |
| Miami Jewish Health Systems | Miami | Florida | 33137 | — |
| Renstar Medical Research | Ocala | Florida | 34470 | — |
| Bioclinica Research | Orlando | Florida | 32806 | — |
| Progressive Medical Research | Port Orange | Florida | 32127 | — |
| Johnnie B. Byrd Sr. Alzheimer's Center & Research Institute | Tampa | Florida | 33613 | — |
| Stedman Clinical Trials, LLC | Tampa | Florida | 33613 | — |
| Compass Research | The Villages | Florida | 32162 | — |
| Emory University | Atlanta | Georgia | 30329 | — |
| NeuroStudies.net, LLC | Decatur | Georgia | 30033 | — |
| Alexian Brothers Neurosci Inst | Elk Grove Village | Illinois | 60007 | — |
| Southern Illinois University, School of Medicine | Springfield | Illinois | 62702 | — |
| Indiana University | Indianapolis | Indiana | 46202 | — |
| MidAmerica Neuroscience Institute | Prairie Village | Kansas | 66206 | — |
| Maine Research Associates | Auburn | Maine | 04210 | — |
| MMP Neurology | Scarborough | Maine | 04074 | — |
| Springfield Neurology Associates | Springfield | Massachusetts | 01104 | — |
| Precise Research Centers | Flowood | Mississippi | 39232 | — |
| The Cognitive and Research Center of New Jersey | Springfield | New Jersey | 07081 | — |
| Advanced Memory Research Institute of NJ | Toms River | New Jersey | 08755 | — |
| Albany Medical Faculty Physicians COmmunity Division. The Neurology Group | Albany | New York | 12206 | — |
| Neurological Associates of Albany, PC | Albany | New York | 12208 | — |
| Dent Neurological Institute | Amherst | New York | 14226 | — |
| Columbia University Medical Center | New York | New York | 10032 | — |
| South Shore Neurologic Associates P.C. | Patchogue | New York | 11772 | — |
| Behavioral Health Research | Charlotte | North Carolina | 28211 | — |
| Guilford Neurologic Associates | Greensboro | North Carolina | 27401 | — |
| Valley Medical Primary Care | Centerville | Ohio | 45459 | — |
| Insight Clinical Trials LLC | Shaker Heights | Ohio | 44122 | — |
| Oklahoma Clinical Research | Oklahoma City | Oklahoma | 73112 | — |
| Cutting Edge Research Group | Oklahoma City | Oklahoma | 73116 | — |
| Central States Research | Tulsa | Oklahoma | 74136 | — |
| Summit Research Network Inc. | Portland | Oregon | 97210 | — |
| Drexel Univ College of Med; Clinical Research Group | Philadelphia | Pennsylvania | 19102 | — |
| Abington Neurological Associates | Willow Grove | Pennsylvania | 19090 | — |
| Senior Adults Specialty Research | Austin | Texas | 78757 | — |
| Kerwin Research Center, LLC | Dallas | Texas | 75231 | — |
| University of North Texas Health Science Center; Fort Worth Patient Care Center | Fort Worth | Texas | 76107 | — |
| Sentara Medical Group | Norfolk | Virginia | 23507 | — |
| National Clinical Research Inc.-Richmond | Richmond | Virginia | 23294 | — |
| Medical College of Wisconsin | Milwaukee | Wisconsin | 53226 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 130 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT02670083, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jul 16, 2020 · Synced Oct 26, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT02670083 live on ClinicalTrials.gov.