A Study of Faricimab (RO6867461) in Participants With Center-Involving Diabetic Macular Edema
Public ClinicalTrials.gov record NCT02699450. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Multiple-Center, Multiple-Dose, Randomized, Active Comparator-Controlled, Double-Masked, Parallel Group, 36-Week Study to Investigate the Safety, Tolerability, Pharmacokinetics, and Efficacy of RO6867461 Administered Intravitreally in Patients With Diabetic Macular Edema
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This is a multiple-center, multiple-dose, randomized, active comparator-controlled, double-masked, three parallel group, 36-week study in participants with center-involving diabetic macular edema (DME). Only one eye will be selected as the study eye. Where both eyes meet all eligibility criteria, the eye with the worse best corrected visual acuity (BCVA) will be defined as the study eye. The study will consist of a treatment period (20 weeks) and an observational period (up to 16 weeks). Treatment naive participants will be randomized in a 1:1:1 ratio to one of the Arms A, B and C, respectively. Participants previously treated with intravitreal (IVT) anti-vascular endothelial growth factor (VEGF) will be randomized in a 1:1 ratio to Arms A and C.
Study identification
- NCT ID
- NCT02699450
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 229 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Apr 27, 2016 (Actual)
- Primary completion
- Sep 15, 2017 (Actual)
- Completion
- Dec 14, 2017 (Actual)
- Last update posted
- Sep 25, 2020
2016 – 2017
United States locations
- U.S. sites
- 60
- U.S. states
- 26
- U.S. cities
- 56
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Retinal Research Institute, LLC | Phoenix | Arizona | 85014 | — |
| Associated Retina Consultants | Phoenix | Arizona | 85020 | — |
| Arizona Retina and Vitreous Consultants | Phoenix | Arizona | 85021 | — |
| Retina Associates Southwest PC | Tucson | Arizona | 85750 | — |
| Retina Consultants of Orange County | Fullerton | California | 92835 | — |
| United Med Res Inst | Inglewood | California | 90301 | — |
| Northern California Retina Vitreous Associates | Mountain View | California | 94040 | — |
| Ophthalmic Clinical Trials San Diego | Oceanside | California | 92056 | — |
| Southern CA Desert Retina Cons | Palm Desert | California | 92211 | — |
| Retina Consultants, San Diego | Poway | California | 92064 | — |
| Retinal Consultants Med Group | Sacramento | California | 95825 | — |
| California Retina Consultants | Santa Barbara | California | 93103 | — |
| Bay Area Retina Associates | Walnut Creek | California | 94598 | — |
| Retina Consultants of Southern | Colorado Springs | Colorado | 80909 | — |
| Rand Eye | Deerfield Beach | Florida | 33064 | — |
| National Ophthalmic Research Institute | Fort Myers | Florida | 33912 | — |
| Florida Eye Associates | Melbourne | Florida | 32901 | — |
| Retina Specialty Institute | Pensacola | Florida | 32503 | — |
| Retina Vitreous Assoc of FL | St. Petersburg | Florida | 33711 | — |
| Southern Vitreoretinal Assoc | Tallahassee | Florida | 32308 | — |
| Southeast Retina Center | Augusta | Georgia | 30909 | — |
| Georgia Retina PC | Marietta | Georgia | 30060 | — |
| Univ of Illinois at Chicago | Chicago | Illinois | 60612 | — |
| University Retina and Macula Associates, PC | Oak Forest | Illinois | 60452 | — |
| Illinois Retina Associates SC | Oak Park | Illinois | 60304 | — |
| Midwest Eye Institute | Indianapolis | Indiana | 46290 | — |
| Wolfe Eye Clinic | West Des Moines | Iowa | 50266 | — |
| Retina Associates of Kentucky | Lexington | Kentucky | 40509 | — |
| Paducah Retinal Center | Paducah | Kentucky | 42001 | — |
| Wilmer Eye Institute | Baltimore | Maryland | 21287 | — |
| Vitreo-Retinal Associates | Grand Rapids | Michigan | 49546 | — |
| Vitreoretinal Surgery | Edina | Minnesota | 55435 | — |
| Sierra Eye Associates | Reno | Nevada | 89502 | — |
| Retina Center of New Jersey | Bloomfield | New Jersey | 07003 | — |
| Eye Associates of New Mexico | Albuquerque | New Mexico | 87102 | — |
| University of New Mexico | Albuquerque | New Mexico | 87131 | — |
| Capital Region Retina | Albany | New York | 12206 | — |
| Opthalmic Consultants of LI | Lynbrook | New York | 11563 | — |
| Retina Consultants of Western New York | Orchard Park | New York | 14127 | — |
| Western Carolina Retinal Associate PA | Asheville | North Carolina | 28803 | — |
| Char Eye Ear &Throat Assoc | Charlotte | North Carolina | 28210 | — |
| Cleveland Clinic Foundation; Cole Eye Institute | Cleveland | Ohio | 44195 | — |
| OSU Eye Physicians & Surgeons | Columbus | Ohio | 43212 | — |
| Oregon Retina, LLP | Eugene | Oregon | 97401 | — |
| Retina Northwest | Portland | Oregon | 97221 | — |
| Palmetto Retina Center | Florence | South Carolina | 29501 | — |
| Charleston Neuroscience Inst | Ladson | South Carolina | 29456 | — |
| Charles Retina Institute | Germantown | Tennessee | 38138 | — |
| Tennessee Retina PC. | Nashville | Tennessee | 37203 | — |
| W Texas Retina Consultants PA | Abilene | Texas | 79606 | — |
| Austin Retina Associates | Austin | Texas | 78705 | — |
| Retina Consultants of Austin | Austin | Texas | 78705 | — |
| Retina Specialists | DeSoto | Texas | 75115 | — |
| Retina Consultants of Houston | Houston | Texas | 77030 | — |
| Med Center Ophthalmology Assoc | San Antonio | Texas | 78240 | — |
| Retina Consultants of Houston | The Woodlands | Texas | 77384 | — |
| Retina Associates of Utah | Salt Lake City | Utah | 84107 | — |
| Univ of Virginia Ophthalmology | Charlottesville | Virginia | 22903 | — |
| Spokane Eye Clinical Research | Spokane | Washington | 99204 | — |
| West Virginia University Eye Institute | Morgantown | West Virginia | 26506 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT02699450, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Sep 25, 2020 · Synced Oct 29, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT02699450 live on ClinicalTrials.gov.