A Study of PEGylated Recombinant Human Hyaluronidase in Combination With Nab-Paclitaxel Plus Gemcitabine Compared With Placebo Plus Nab-Paclitaxel and Gemcitabine in Participants With Hyaluronan-High Stage IV Previously Untreated Pancreatic Ductal Adenocarcinoma
Public ClinicalTrials.gov record NCT02715804. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 3, Randomized, Double-Blind, Placebo-Controlled, Multicenter Study of PEGylated Recombinant Human Hyaluronidase (PEGPH20) in Combination With Nab-Paclitaxel Plus Gemcitabine Compared With Placebo Plus Nab-Paclitaxel and Gemcitabine in Subjects With Hyaluronan-High Stage IV Previously Untreated Pancreatic Ductal Adenocarcinoma
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The purpose of this study is to compare the efficacy and safety of PEGylated Recombinant Human Hyaluronidase (PEGPH20) combined with nab-paclitaxel plus gemcitabine (PAG treatment), compared with placebo combined with nab-paclitaxel plus gemcitabine (AG treatment), in participants with hyaluronan (HA)-high Stage IV previously untreated pancreatic ductal adenocarcinoma (PDA).
Study identification
- NCT ID
- NCT02715804
- Recruitment status
- Terminated
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 492 participants
Conditions and interventions
Conditions
Interventions
- Biological: PEGylated Recombinant Human Hyaluronidase (PEGPH20) Other
- Placebo Drug
- nab-Paclitaxel Drug
- Gemcitabine Drug
Other · Drug
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Mar 14, 2016 (Actual)
- Primary completion
- Nov 4, 2019 (Actual)
- Completion
- Nov 4, 2019 (Actual)
- Last update posted
- Jul 14, 2020
2016 – 2019
United States locations
- U.S. sites
- 64
- U.S. states
- 29
- U.S. cities
- 55
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| University of South Alabama | Mobile | Alabama | 36604 | — |
| Banner MD Anderson Cancer Center | Gilbert | Arizona | 85234-2165 | — |
| Highlands Oncology Group | Fayetteville | Arkansas | 72703 | — |
| St. Jude Hospital Yorba DBA Linda St. Joseph Heritage Health | Fullerton | California | 92886 | — |
| Scripps Clinical Research Services | La Jolla | California | 92037 | — |
| Samuel Oschin Comprehensive Cancer Institute | Los Angeles | California | 90048 | — |
| David Geffen School of Medicine (DGSOM) at UCLA | Los Angeles | California | 90095 | — |
| Chao Family Comprehensive Cancer Center | Orange | California | 92868 | — |
| St. Joseph Hospital | Orange | California | 92868 | — |
| Desert Hematology Oncology Medical Group, Inc. | Rancho Mirage | California | 92270 | — |
| Cancer Care Associates Medical Group, Inc. | Redondo Beach | California | 90277 | — |
| Pacific Hematology Oncology Associates | San Francisco | California | 94115 | — |
| UCSF Helen Diller Family Comprehensive Cancer Center | San Francisco | California | 94115 | — |
| Pacific Central Coast Health Centers: San Luis Obispo Oncology and Hematology Health Center | San Luis Obispo | California | 93401 | — |
| St Joseph Heritage Healthcare | Santa Rosa | California | 95405 | — |
| Innovative Clinical Research Institution | Whittier | California | 90603 | — |
| Kaiser Permanente Franklin Medical Offices - Denver | Denver | Colorado | 80205 | — |
| US Oncology - Rocky Mountain Cancer Centers - Midtown | Denver | Colorado | 80218 | — |
| St. Mary's Medical Center | Grand Junction | Colorado | 81501 | — |
| Yale Cancer Center | New Haven | Connecticut | 06510 | — |
| MedStar Georgetown University Hospital | Washington D.C. | District of Columbia | 20007 | — |
| Memorial Healthcare System - Memorial Cancer Institute | Hollywood | Florida | 33021 | — |
| 21st Century Oncology | Jacksonville | Florida | 32207 | — |
| MD Anderson Cancer Center Orlando | Orlando | Florida | 32806 | — |
| Fort Wayne Medical Oncology/Hematology, INC. | Fort Wayne | Indiana | 46845 | — |
| The University Of Kansas Cancer Center | Kansas City | Kansas | 66160 | — |
| University of Louisville | Louisville | Kentucky | 40292 | — |
| Ochsner Health Center | Baton Rouge | Louisiana | 70809 | — |
| Ochsner Clinic CCOP | New Orleans | Louisiana | 70119 | — |
| The Sidney Kimmel Comprehensive Cancer Center | Baltimore | Maryland | 21224 | — |
| Beth Israel Deaconess Medical Center | Boston | Massachusetts | 02215 | — |
| UMass Memorial Medical Center | Worcester | Massachusetts | 01605 | — |
| University of Michigan Medical Center | Ann Arbor | Michigan | 48109 | — |
| Karmanos Cancer Institute | Detroit | Michigan | 48201 | — |
| Virginia Piper Cancer Institute | Minneapolis | Minnesota | 55404 | — |
| University of Minnesota Medical School | Minneapolis | Minnesota | 55455 | — |
| Comprehensive Cancer Centers of Nevada | Las Vegas | Nevada | 89169 | — |
| Renown Regional Medical Center | Reno | Nevada | 89502 | — |
| Dartmouth Hitchcock Medical Center | Lebanon | New Hampshire | 03743 | — |
| Saint Joseph's Ambulatory Clinic | Clifton | New Jersey | 07013 | — |
| Jersey Shore University Medical Center | Neptune City | New Jersey | 07753 | — |
| Northwell Health/Monter Cancer Center | Lake Success | New York | 11042 | — |
| NYU Langone Medical Center - NYU Langone Arena Oncology | New Hyde Park | New York | 10016 | — |
| Columbia University Medical Center | New York | New York | 10019 | — |
| Mount Sinai School of Medicine - The Tisch Cancer Institute | New York | New York | 10029 | — |
| University of Rochester Medical Center | Rochester | New York | 14642 | — |
| Rex Cancer Center | Raleigh | North Carolina | 27607 | — |
| Gabrail Cancer Center Research | Canton | Ohio | 44718 | — |
| The University of Oklahoma Health Sciences Center | Oklahoma City | Oklahoma | 73104 | — |
| Penn State Milton S. Hershey Medical Center | Hershey | Pennsylvania | 17033 | — |
| Allegheny General Hospital | Pittsburgh | Pennsylvania | 15212 | — |
| Univ of Pittsburgh Cancer institute | Pittsburgh | Pennsylvania | 15232 | — |
| Baylor College of Medicine - Baylor Clinic | Houston | Texas | 77030 | — |
| Scott and White | Temple | Texas | 76508 | — |
| University of Utah - Huntsman Cancer Institute | Salt Lake City | Utah | 84103 | — |
| Inova Dwight and Martha Schar Cancer Institute | Fairfax | Virginia | 22031 | — |
| Fort Belvoir Community Hospital | Fort Belvoir | Virginia | 22060 | — |
| Virginia Cancer Institute | Mechanicsville | Virginia | 23116 | — |
| Swedish Cancer Institute/ Swedish Health Services | Seattle | Washington | 98104 | — |
| University of Washington (UW) - Seattle Cancer Care Alliance | Seattle | Washington | 98195 | — |
| Northwest Medical Specialties PLLC | Tacoma | Washington | 98405 | — |
| University of Wisconsin Health - UW Carbone Cancer Center | Madison | Wisconsin | 53792 | — |
| Columbia St. Marys | Milwaukee | Wisconsin | 53211 | — |
| Medical College of Wisconsin | Milwaukee | Wisconsin | 53226 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 153 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT02715804, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jul 14, 2020 · Synced Oct 26, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT02715804 live on ClinicalTrials.gov.