A Study to Assess the Efficacy and Safety of AXS-05 in Subjects With Treatment Resistant Major Depressive Disorder
Public ClinicalTrials.gov record NCT02741791. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
STRIDE-1: A Randomized, Double-blind, Active-controlled Trial to Assess the Efficacy and Safety of AXS-05 Administered Orally to Subjects With Treatment Resistant Major Depressive Disorder
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
To evaluate the efficacy and safety of AXS-05 relative to bupropion in subjects with treatment resistant major depressive disorder (MDD). This is a randomized, double-blind, active-controlled, 12-week, two-period study consisting of an open-label, bupropion lead-in period, and a double-blind treatment period. The trial is being conducted in subjects with treatment resistant MDD. Subjects will be considered to have treatment resistant MDD if they have had a historical inadequate response to 1 or 2 antidepressant treatments and a prospective inadequate response to treatment with bupropion during the open-label, lead-in period.
Study identification
- NCT ID
- NCT02741791
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 312 participants
Conditions and interventions
Eligibility (public fields only)
- Age range
- 18 Years to 65 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Mar 2016 (Type not available)
- Primary completion
- Mar 20, 2020 (Actual)
- Completion
- Mar 20, 2020 (Actual)
- Last update posted
- Mar 24, 2021
2016 – 2020
United States locations
- U.S. sites
- 74
- U.S. states
- 32
- U.S. cities
- 74
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Not listed | Phoenix | Arizona | — | — |
| Not listed | Little Rock | Arkansas | — | — |
| Not listed | Anaheim | California | — | — |
| Not listed | Beverly Hills | California | — | — |
| Not listed | Garden Grove | California | — | — |
| Not listed | Oakland | California | — | — |
| Not listed | Oceanside | California | — | — |
| Not listed | Panorama City | California | — | — |
| Not listed | Redlands | California | — | — |
| Not listed | Riverside | California | — | — |
| Not listed | San Diego | California | — | — |
| Not listed | San Francisco | California | — | — |
| Not listed | Sherman Oaks | California | — | — |
| Not listed | Temecula | California | — | — |
| Not listed | Upland | California | — | — |
| Not listed | Colorado Springs | Colorado | — | — |
| Not listed | Cromwell | Connecticut | — | — |
| Not listed | Washington D.C. | District of Columbia | 20016 | — |
| Not listed | Coral Springs | Florida | — | — |
| Not listed | Fort Lauderdale | Florida | — | — |
| Not listed | Fort Myers | Florida | — | — |
| Not listed | Gainesville | Florida | — | — |
| Not listed | Jacksonville | Florida | 32256 | — |
| Not listed | Lakeland | Florida | — | — |
| Not listed | North Miami | Florida | — | — |
| Not listed | Orlando | Florida | — | — |
| Not listed | Pensacola | Florida | — | — |
| Not listed | St. Petersburg | Florida | — | — |
| Not listed | Atlanta | Georgia | 30328 | — |
| Not listed | Boise | Idaho | — | — |
| Not listed | Skokie | Illinois | — | — |
| Not listed | Shreveport | Louisiana | — | — |
| Not listed | Baltimore | Maryland | — | — |
| Not listed | Saint Charles | Missouri | — | — |
| Not listed | St Louis | Missouri | — | — |
| Not listed | Lincoln | Nebraska | — | — |
| Not listed | Las Vegas | Nevada | — | — |
| Not listed | Nashua | New Hampshire | — | — |
| Not listed | Berlin | New Jersey | — | — |
| Not listed | Cherry Hill | New Jersey | — | — |
| Not listed | Marlton | New Jersey | — | — |
| Not listed | Princeton | New Jersey | — | — |
| Not listed | Toms River | New Jersey | — | — |
| Not listed | Albuquerque | New Mexico | — | — |
| Not listed | Brooklyn | New York | — | — |
| Not listed | Jamaica | New York | 11432 | — |
| Not listed | New York | New York | — | — |
| Not listed | Rochester | New York | — | — |
| Not listed | Staten Island | New York | — | — |
| Not listed | Charlotte | North Carolina | — | — |
| Not listed | Canton | Ohio | — | — |
| Not listed | Dayton | Ohio | — | — |
| Not listed | Middleburg Heights | Ohio | — | — |
| Not listed | Oklahoma City | Oklahoma | — | — |
| Not listed | Portland | Oregon | — | — |
| Not listed | Salem | Oregon | — | — |
| Not listed | Allentown | Pennsylvania | — | — |
| Not listed | Media | Pennsylvania | — | — |
| Not listed | Philadelphia | Pennsylvania | — | — |
| Not listed | Lincoln | Rhode Island | — | — |
| Not listed | Charleston | South Carolina | — | — |
| Not listed | Memphis | Tennessee | 38119 | — |
| Not listed | Austin | Texas | — | — |
| Not listed | Dallas | Texas | — | — |
| Not listed | Houston | Texas | — | — |
| Not listed | San Antonio | Texas | — | — |
| Not listed | Wichita Falls | Texas | — | — |
| Not listed | Orem | Utah | — | — |
| Not listed | Charlottesville | Virginia | — | — |
| Not listed | Herndon | Virginia | — | — |
| Not listed | Bellevue | Washington | — | — |
| Not listed | Seattle | Washington | — | — |
| Not listed | Spokane | Washington | — | — |
| Not listed | Waukesha | Wisconsin | — | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT02741791, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Mar 24, 2021 · Synced Oct 30, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT02741791 live on ClinicalTrials.gov.