A Study of Napabucasin (BBI-608) in Combination With FOLFIRI in Adult Patients With Previously Treated Metastatic Colorectal Cancer
Public ClinicalTrials.gov record NCT02753127. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 3 Study of BBI-608 in Combination With 5-Fluorouracil, Leucovorin, Irinotecan (FOLFIRI) in Adult Patients With Previously Treated Metastatic Colorectal Cancer (CRC).
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This is an international multi-center, prospective, open-label, randomized, adaptive design phase 3 trial of the cancer stem cell pathway inhibitor napabucasin plus standard bi-weekly FOLFIRI versus standard bi-weekly FOLFIRI in patients with previously treated metastatic colorectal cancer (CRC).
Study identification
- NCT ID
- NCT02753127
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 1,253 participants
Conditions and interventions
Conditions
Interventions
- Napabucasin Drug
- Fluorouracil Drug
- Leucovorin Drug
- Irinotecan Drug
- Bevacizumab Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jun 2016 (Type not available)
- Primary completion
- Apr 28, 2020 (Actual)
- Completion
- May 12, 2021 (Actual)
- Last update posted
- Nov 15, 2023
2016 – 2021
United States locations
- U.S. sites
- 74
- U.S. states
- 29
- U.S. cities
- 69
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Alabama Oncology | Birmingham | Alabama | 35223 | — |
| Mayo Clinic Arizona | Phoenix | Arizona | 85054 | — |
| Arizona Oncology Associates, PC - HOPE | Tucson | Arizona | 85771 | — |
| Comprehensive Blood and Cancer Center | Bakersfield | California | 93309 | — |
| City of Hope- Comprehensive Care Center | Duarte | California | 91010 | — |
| University of California-San Diego/Moores UCSD Cancer Center | La Jolla | California | 92093 | — |
| Los Angeles Hematology Oncology Medical Group | Los Angeles | California | 90017 | — |
| USC Norris Comprehensive Cancer Center | Los Angeles | California | 90033 | — |
| UCLA Hematology Oncology Santa Monica | Santa Monica | California | 90404 | — |
| St. Joseph Heritage Healthcare | Santa Rosa | California | 95405 | — |
| Rocky Mountain Cancer Centers | Denver | Colorado | 80218 | — |
| St Mary's Hospital & Regional Med Center | Grand Junction | Colorado | 81501 | — |
| Medical Oncology Hematology Consultants, PA | Newark | Delaware | 19713 | — |
| Florida Cancer Specialists & Research Institute Fort Myers | Fort Myers | Florida | 33901 | — |
| Memorial Cancer Institute at Memorial Hospital | Hollywood | Florida | 33021 | — |
| Baptist Health Medical Group Oncology, LLC | Miami | Florida | 33176 | — |
| Sarah Cannon Research Institution | St. Petersburg | Florida | 33705 | — |
| Palm Beach Cancer Institute | West Palm Beach | Florida | 33401 | — |
| Piedmont Cancer Institute, PC | Atlanta | Georgia | 30318 | — |
| Emory University/Winship Cancer Institute | Atlanta | Georgia | 30322 | — |
| Suburban Hematology-Oncology Associates, PC - Lawrenceville | Lawrenceville | Georgia | 30046 | — |
| Illinois Cancer Specialists | Arlington Heights | Illinois | 60005 | — |
| Northshore University Healthsystem | Evanston | Illinois | 60201 | — |
| Healthcare Research Network III, LLC | Tinley Park | Illinois | 60487 | — |
| Northwestern Medicine Cancer Center | Warrenville | Illinois | 60555 | — |
| Parkview Research Center | Fort Wayne | Indiana | 46845 | — |
| Indiana University Health Goshen Center for Cancer Care | Goshen | Indiana | 46526 | — |
| Michiana Hematology Oncology, PC | Mishawaka | Indiana | 46545 | — |
| Cancer Center of Kansas | Wichita | Kansas | 67214 | — |
| Dana Farber | Boston | Massachusetts | 02215 | — |
| Umass Memorial Medical Center | Worcester | Massachusetts | 01655 | — |
| University of Michigan Cancer Center | Ann Arbor | Michigan | — | — |
| Minnesota Oncology Hematology, P.A. | Minneapolis | Minnesota | 55404 | — |
| Mayo Clinic Arizona | Rochester | Minnesota | 55905 | — |
| Research Medical Center | Kansas City | Missouri | 64132 | — |
| Missouri Baptist Medical Center ACCRU Network Site | St Louis | Missouri | 63131 | — |
| Saint Francis Cancer Treatment Center | Grand Island | Nebraska | 68803 | — |
| Missouri Valley Cancer Consortium | Omaha | Nebraska | 68106 | — |
| Cancer Research Network of Nebraska / Oncology Associates PC | Omaha | Nebraska | 68118 | — |
| Tennessee Oncology PLLC | Omaha | Nebraska | 68118 | — |
| Darthmouth-Hitchcock Medical Center | Lebanon | New Hampshire | 03756 | — |
| Carol G. Simon Cancer Center | Morristown | New Jersey | 07962 | — |
| University of New Mexico | Albuquerque | New Mexico | 87131 | — |
| Roswell Park Cancer Center | Buffalo | New York | 14263 | — |
| North Shore Hematology Oncology Associates | East Setauket | New York | 11733 | — |
| Weill Cornell Medical College | New York | New York | 10065 | — |
| Montefiore Medical Center | The Bronx | New York | 10467 | — |
| Southeastern Medical Oncology Center | Goldsboro | North Carolina | 27534 | — |
| Wake Forest Baptist Medical Center | Winston-Salem | North Carolina | 27157 | — |
| Toledo Clinic Cancer Centers | Toledo | Ohio | 43623 | — |
| Geisinger Medical Center | Danville | Pennsylvania | 17822 | — |
| VA Pittsburgh Healthcare System | Pittsburgh | Pennsylvania | 15240 | — |
| Medical University of South Carolina | Charleston | South Carolina | 29412 | — |
| Sanford Cancer Center | Sioux Falls | South Dakota | 57104 | — |
| University of Tennessee Medical Center | Knoxville | Tennessee | 37920 | — |
| West Cancer Center | Memphis | Tennessee | 38138 | — |
| The Sarah Cannon Research Institute | Nashville | Tennessee | 37203 | — |
| Texas Oncology-Austin Midtown | Austin | Texas | 75705 | — |
| Texas Oncology - Dallas Center | Dallas | Texas | 75203 | — |
| Texas Oncology - Denton South | Denton | Texas | 76210 | — |
| Texas Oncology - Fort Worth | Fort Worth | Texas | 76104 | — |
| Millenium Oncology | Houston | Texas | 77090 | — |
| Texas Health Physicians Group | Plano | Texas | 75093 | — |
| Texas Oncology-San Antonio | San Antonio | Texas | 78217 | — |
| Texas Oncology - Tyler | Tyler | Texas | 75702 | — |
| Texas Oncology - Wichita Falls Texoma Cancer Center | Wichita Falls | Texas | 76310 | — |
| Northern Utah Associates | Ogden | Utah | 84403 | — |
| US Oncology - Virginia Cancer Specialists, PC | Fairfax | Virginia | 22031 | — |
| Fort Belvoir Community Hospital | Fort Belvoir | Virginia | 22060 | — |
| Virginia Oncology Associates | Hampton | Virginia | 23666 | — |
| Blue Ridge Cancer Care | Roanoke | Virginia | 24014 | — |
| Virginia Mason | Seattle | Washington | 98101 | — |
| Seattle Cancer Care Alliance | Seattle | Washington | 98109-1023 | — |
| Northwest Cancer Specialists, P.C. | Vancouver | Washington | 98684 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 137 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT02753127, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Nov 15, 2023 · Synced Oct 17, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT02753127 live on ClinicalTrials.gov.