ClinicalTrials.gov record
A Study to Evaluate the Safety and Efficacy of Upadacitinib (ABT-494) for Induction and Maintenance Therapy in Participants With Moderately to Severely Active Ulcerative Colitis (UC)
ClinicalTrials.gov ID: NCT02819635
Public ClinicalTrials.gov record NCT02819635. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
ClinicalTrials.gov public records Last synced May 18, 2026, 1:02 PM EDT
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Safety and Efficacy of Upadacitinib (ABT-494) for Induction and Maintenance Therapy in Subjects With Moderately to Severely Active Ulcerative Colitis
Study identification
- NCT ID
- NCT02819635
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2, Phase 3
- Lead sponsor
- AbbVie
- Industry
- Enrollment
- 1,302 participants
Conditions and interventions
Conditions
Interventions
- Placebo Drug
- Upadacitinib Drug
Drug
Eligibility (public fields only)
- Age range
- 16 Years to 75 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Sep 25, 2016
- Primary completion
- Dec 12, 2021
- Completion
- Dec 12, 2021
- Last update posted
- Jun 29, 2022
2016 – 2021
United States locations
- U.S. sites
- 149
- U.S. states
- 37
- U.S. cities
- 117
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Birmingham Gastroenterology Associates P.C /ID# 151276 | Birmingham | Alabama | 35209 | — |
| East View Medical Research, LLC /ID# 171183 | Mobile | Alabama | 36606 | — |
| CB Flock Research Corporation /ID# 165980 | Mobile | Alabama | 36608 | — |
| Delsol Research Management, Ll /Id# 170131 | Chandler | Arizona | 85224 | — |
| Digestive Disease Consultants, A Division of Arizona Digestive Health, P.C /ID# 211885 | Mesa | Arizona | 85206 | — |
| Arizona Arthritis & Rheumatology Research, PLLC /ID# 169822 | Sun City | Arizona | 85306 | — |
| Adobe Clinical Research LLC /ID# 155250 | Tucson | Arizona | 85712 | — |
| University of Arizona /ID# 150553 | Tucson | Arizona | 85724 | — |
| Citrus Valley Gastroenterology /ID# 151914 | Covina | California | 91722-3797 | — |
| Newport Huntington Medical Group /ID# 217005 | Huntington Beach | California | 92648-5994 | — |
| UC San Diego Health System /ID# 155185 | La Jolla | California | 92093 | — |
| United Medical Doctors /ID# 207464 | Los Alamitos | California | 90720-3309 | — |
| TLC Clinical Research Inc /ID# 216829 | Los Angeles | California | 90048 | — |
| Gastrointestinal Biosciences Clinical Trials, LLC /ID# 157080 | Los Angeles | California | 90067-2001 | — |
| Facey Medical Foundation /ID# 203133 | Mission Hills | California | 91345 | — |
| United Medical Doctors - Murrieta /ID# 151211 | Murrieta | California | 92563 | — |
| InSite Digestive Health Care - Oxnard /ID# 163414 | Oxnard | California | 93030 | — |
| Inland Empire Clinical Trials, LLC /ID# 216038 | Rialto | California | 92377 | — |
| San Diego Clinical Trials /ID# 212120 | San Diego | California | 92120 | — |
| Medical Assoc Research Grp /ID# 169148 | San Diego | California | 92123 | — |
| Univ of California San Francis /ID# 164581 | San Francisco | California | 94158 | — |
| Delta Waves, Inc. /ID# 151721 | Colorado Springs | Colorado | 80918 | — |
| South Denver Gastroenterology /ID# 151223 | Lone Tree | Colorado | 80124 | — |
| Western States Clinical Res /ID# 158076 | Wheat Ridge | Colorado | 80033-2896 | — |
| Western Connecticut Medical Group /ID# 169210 | Danbury | Connecticut | 06810 | — |
| Medical Research Center of CT /ID# 150482 | Hamden | Connecticut | 06518 | — |
| Gastro Florida /ID# 155245 | Clearwater | Florida | 33756 | — |
| Moonshine Research Center, Inc /ID# 152533 | Doral | Florida | 33166 | — |
| Universal Axon Clinical Research /ID# 213461 | Doral | Florida | 33166 | — |
| Palmetto Research, LLC /ID# 151716 | Hialeah | Florida | 33016 | — |
| Nature Coast Clinical Research - Inverness /ID# 154064 | Inverness | Florida | 34452-4717 | — |
| Encore Borland-Groover Clinical Research /Id# 170912 | Jacksonville | Florida | 32256 | — |
| SIH Research Mumtaz, Inc /ID# 163319 | Kissimmee | Florida | 34741-4161 | — |
| Cfagi Llc /Id# 202017 | Maitland | Florida | 32751-6108 | — |
| University of Miami /ID# 215441 | Miami | Florida | 33136 | — |
| Advanced Pharma /ID# 151719 | Miami | Florida | 33147 | — |
| New Horizon Research Center /ID# 152474 | Miami | Florida | 33165-3372 | — |
| Crystal Pharmacology Research /ID# 151841 | Miami | Florida | 33165 | — |
| Coral Research Clinic /ID# 150444 | Miami | Florida | 33186-4643 | — |
| Advanced Research Institute, Inc /ID# 163098 | New Port Richey | Florida | 34653 | — |
| Endoscopic Research, Inc. /ID# 151720 | Orlando | Florida | 32803 | — |
| Omega Research Maitland, LLC /ID# 200269 | Orlando | Florida | 32808 | — |
| Clinical Research Trials of Florida, Inc. /ID# 201790 | Tampa | Florida | 33607 | — |
| University of South Florida /ID# 214493 | Tampa | Florida | 33612 | — |
| AdventHealth Tampa /ID# 200272 | Tampa | Florida | 33613-4680 | — |
| Gastroenterology Associates of Central Georgia, LLC /ID# 165782 | Macon | Georgia | 31201 | — |
| Infinite Clinical Trials /ID# 215340 | Riverdale | Georgia | 30274 | — |
| Atlanta Gastroenterology Spec /ID# 150548 | Suwanee | Georgia | 30024 | — |
| Next Innovative Clinical Research - Chicago /ID# 216060 | Chicago | Illinois | 60605-2168 | — |
| The University of Chicago DCAM /ID# 150547 | Chicago | Illinois | 60637 | — |
| NorthShore University HealthSystem /ID# 150555 | Evanston | Illinois | 60201 | — |
| Northwest Health Care Associates /ID# 151590 | Hoffman Estates | Illinois | 60169 | — |
| Carle Foundation Hospital /ID# 151137 | Urbana | Illinois | 61801 | — |
| MediSphere Medical Research Center /ID# 152064 | Evansville | Indiana | 47714-8011 | — |
| Indianapolis Gastroenterology /ID# 162901 | Indianapolis | Indiana | 46237 | — |
| University of Iowa Hospitals and Clinics /ID# 157058 | Iowa City | Iowa | 52242 | — |
| Cotton-O'Neil Clinical Res Ctr /ID# 167182 | Topeka | Kansas | 66606 | — |
| Tri-State Gastroenterology /ID# 169811 | Crestview Hills | Kentucky | 41017 | — |
| Houma Digestive Health Special /ID# 151844 | Houma | Louisiana | 70360 | — |
| Nola Research Works, LLC /ID# 153356 | New Orleans | Louisiana | 70115 | — |
| Louisana Research Center, LLC /ID# 150446 | Shreveport | Louisiana | 71105-6800 | — |
| University of Maryland Med Ctr /ID# 150449 | Baltimore | Maryland | 21201 | — |
| Gastro Center of Maryland /ID# 200022 | Columbia | Maryland | 21045 | — |
| Massachusetts General Hospital /ID# 165676 | Boston | Massachusetts | 02114 | — |
| University of Michigan Comprehensive Cancer Center Michigan Medicine /ID# 151140 | Ann Arbor | Michigan | 48109 | — |
| Huron Gastroenterology Assoc /ID# 152710 | Ann Arbor | Michigan | 48197 | — |
| Clin Res Inst of Michigan, LLC /ID# 153027 | Chesterfield | Michigan | 48047 | — |
| Revival Research Institute, LLC /ID# 207280 | Southfield | Michigan | 48034-1659 | — |
| Center for Digestive Health /ID# 161984 | Troy | Michigan | 48098-6363 | — |
| Gastroenterology Associates of Western Michigan, PLC d.b.a. West Michigan Clinic /ID# 157484 | Wyoming | Michigan | 49519 | — |
| Mayo Clinic - Rochester /ID# 151677 | Rochester | Minnesota | 55905-0001 | — |
| Minnesota Gastroenterology PA /ID# 151678 | Saint Paul | Minnesota | 55114 | — |
| University of Mississippi Medical Center /ID# 213139 | Jackson | Mississippi | 39216-4500 | — |
| Southern Therapy and Advanced Research (STAR) LLC /ID# 170712 | Jackson | Mississippi | 39216 | — |
| Washington University-School of Medicine /ID# 150485 | St Louis | Missouri | 63110 | — |
| Las Vegas Medical Research /ID# 153044 | Las Vegas | Nevada | 89113 | — |
| Dartmouth-Hitchcock Medical Center /ID# 150549 | Lebanon | New Hampshire | 03756 | — |
| AGA Clinical Research Associates, LLC /ID# 153040 | Egg Harbor | New Jersey | 08234 | — |
| Atlantic Digestive Health Inst /ID# 150447 | Morristown | New Jersey | 07960 | — |
| Rutgers Robert Wood Johnson /ID# 155248 | New Brunswick | New Jersey | 08901 | — |
| Duplicate_University of New Mexico Department of Internal Medicine /ID# 214396 | Albuquerque | New Mexico | 87131 | — |
| NY Scientific /ID# 152707 | Brooklyn | New York | 11235 | — |
| NYU Langone Long Island Clinical Research Association /ID# 155272 | Great Neck | New York | 11021 | — |
| Columbia Univ Medical Center /ID# 163410 | New York | New York | 10032-3725 | — |
| DiGiovanna Institute for Medical Education & Research /ID# 201533 | North Massapequa | New York | 11758 | — |
| Premier Medical Group - GI Division /ID# 153357 | Poughkeepsie | New York | 12601 | — |
| Gastoenterology Group of Rochester /ID# 151079 | Rochester | New York | 14618-5703 | — |
| Richmond University Medical Center /ID# 201859 | Staten Island | New York | 10310-1664 | — |
| Montefiore Medical Center - Moses Campus /ID# 150543 | The Bronx | New York | 10467 | — |
| Advantage Clinical Trials /ID# 163938 | The Bronx | New York | 10468 | — |
| Digestive Health Partners, P.A /ID# 167237 | Asheville | North Carolina | 28801 | — |
| Atrium Health Carolinas Medical Center /ID# 156971 | Charlotte | North Carolina | 28203 | — |
| Charlotte Gastroenterology and Hepatology, PLLC /ID# 150545 | Charlotte | North Carolina | 28207 | — |
| Atlantic Gastroenterology Clinical Research /ID# 151899 | Greenville | North Carolina | 27834 | — |
| Clinical Trials of America /ID# 153448 | Winston-Salem | North Carolina | 27103 | — |
| Wake Forest Baptist Medical Center /ID# 150448 | Winston-Salem | North Carolina | 27157-0001 | — |
| Plains Clinical Research Center, LLC /ID# 170290 | Fargo | North Dakota | 58104-5925 | — |
| Consultants for Clinical Research /ID# 151679 | Cincinnati | Ohio | 45219 | — |
| University of Cincinnati /ID# 164582 | Cincinnati | Ohio | 45267-0585 | — |
| The Ohio State University /ID# 169416 | Columbus | Ohio | 43210 | — |
| Optimed Research, Ltd. /ID# 169696 | Columbus | Ohio | 43235 | — |
| Hometown Urgent Care and Resea /ID# 200065 | Dayton | Ohio | 45424 | — |
| Dayton Gastroenterology, Inc. /ID# 167631 | Englewood | Ohio | 45415 | — |
| Great Lakes Medical Research, LLC /ID# 201772 | Mentor | Ohio | 44060-6211 | — |
| Ohio Clinical Research Partner /ID# 154068 | Mentor | Ohio | 44060 | — |
| Hightower Clinical /ID# 216337 | Oklahoma City | Oklahoma | 73102 | — |
| Digestive Disease Specialists /ID# 201056 | Oklahoma City | Oklahoma | 73112 | — |
| Options Health Research, LLC /ID# 150554 | Tulsa | Oklahoma | 74104 | — |
| Healthcare Research Consultant /ID# 163100 | Tulsa | Oklahoma | 74135 | — |
| Northwest Gastroenterology Clinic /ID# 152527 | Portland | Oregon | 97210 | — |
| Guthrie Medical Group, PC /ID# 150481 | Sayre | Pennsylvania | 18840 | — |
| Penn State Health Colonnade /ID# 150259 | State College | Pennsylvania | 16803-2309 | — |
| Pharmacorp Clinical Trials /ID# 153354 | Charleston | South Carolina | 29412 | — |
| Gastroenterology Associates, P.A. of Greenville /ID# 150541 | Greenville | South Carolina | 29615-3593 | — |
| Gastro One /ID# 151144 | Germantown | Tennessee | 38138 | — |
| East Tennessee Research Institute /ID# 203610 | Johnson City | Tennessee | 37604 | — |
| Quality Medical Research /ID# 203426 | Nashville | Tennessee | 37211 | — |
| Vanderbilt University Medical Center /ID# 153355 | Nashville | Tennessee | 37232-0011 | — |
| TX Clinical Research Institute /ID# 151526 | Arlington | Texas | 76012 | — |
| Inquest Clinical Research /ID# 164635 | Baytown | Texas | 77521-2415 | — |
| Texas Digestive Disease Consultants /ID# 209947 | Cedar Park | Texas | 78613-5028 | — |
| Texas Digestive Disease Consultants /ID# 209804 | Cedar Park | Texas | 78613 | — |
| Baylor Scott & White Center for Inflammatory Bowel Diseases /ID# 200770 | Dallas | Texas | 75246 | — |
| DHAT Research Institute /ID# 151218 | Garland | Texas | 75044-2208 | — |
| Vilo Research Group Inc /ID# 212624 | Houston | Texas | 77017-2337 | — |
| CliniCore International, LLC /ID# 152062 | Houston | Texas | 77027-6812 | — |
| Baylor College of Medicine - Baylor Medical Center /ID# 150486 | Houston | Texas | 77030-3411 | — |
| Centex Studies, Inc. - Houston /ID# 201216 | Houston | Texas | 77058 | — |
| GI Specialists of Houston /ID# 202327 | Houston | Texas | 77070-4347 | — |
| Caprock Gastro Research, LLC /ID# 214754 | Lubbock | Texas | 79424-3017 | — |
| Clinical Associates in Research Therapeutics of America, LLC /ID# 201260 | San Antonio | Texas | 78212 | — |
| Southern Star Research Institute, LLC /ID# 169396 | San Antonio | Texas | 78229-5390 | — |
| Carl R. Meisner Medical Clinic /ID# 171061 | Sugar Land | Texas | 77478 | — |
| Baylor Scott & White Center for Diagnostic Medicine /ID# 204499 | Temple | Texas | 76508 | — |
| Tyler Research Institute, LLC /ID# 169146 | Tyler | Texas | 75701-4464 | — |
| Gastro Health & Nutrition - Victoria /ID# 167761 | Victoria | Texas | 77904 | — |
| HP Clinical Research /ID# 163939 | Bountiful | Utah | 84010 | — |
| Advanced Research Institute /ID# 162624 | Ogden | Utah | 84403 | — |
| Utah Gastroenternology - St. Mark's Office /ID# 163101 | Salt Lake City | Utah | 84124 | — |
| Velocity Clinical Research - Salt Lake City /ID# 163181 | West Jordan | Utah | 84088 | — |
| Ctr for Gastrointestinal Healt /ID# 153360 | Franklin | Virginia | 23851 | — |
| Emeritas Research Group, LLC /ID# 150258 | Leesburg | Virginia | 20176 | — |
| Washington Gastroenterology /ID# 163629 | Bellevue | Washington | 98004 | — |
| Virginia Mason Medical Center /ID# 153026 | Seattle | Washington | 98101 | — |
| The Polyclinic /ID# 164369 | Seattle | Washington | 98122-4201 | — |
| The Vancouver Clinic, INC. PS /ID# 162333 | Vancouver | Washington | 98664 | — |
| Aurora Medical Center - Grafto /ID# 151717 | Grafton | Wisconsin | 53024 | — |
| Wisconsin Center for Advanced Research, a division of GI Associates, LLC /ID# 151838 | Milwaukee | Wisconsin | 53215 | — |
| Medical College of Wisconsin /ID# 151843 | Milwaukee | Wisconsin | 53226-3522 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 347 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT02819635, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jun 29, 2022 · Synced May 18, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT02819635 live on ClinicalTrials.gov.