Methotrexate Withdrawal Study of Tofacitinib Modified Release Formulation in Subjects With Rheumatoid Arthritis
Public ClinicalTrials.gov record NCT02831855. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A PHASE 3B/4 RANDOMIZED DOUBLE BLIND PLACEBO CONTROLLED STUDY OF METHOTREXATE (MTX) WITHDRAWAL IN SUBJECTS WITH RHEUMATOID ARTHRITIS (RA) TREATED WITH TOFACITINIB 11MG MODIFIED RELEASE (MR) FORMULATION
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This study is designed to evaluate the efficacy and safety of tofacitinib modified release formulation (11mg QD) versus tofacitinib modified release formulation plus continued methotrexate treatment in subjects with moderate to severe rheumatoid arthritis who are insufficiently responding to their stable dose of methotrexate treatment.
Study identification
- NCT ID
- NCT02831855
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 4
- Enrollment
- 694 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Sep 1, 2016 (Actual)
- Primary completion
- Nov 19, 2018 (Actual)
- Completion
- Dec 17, 2018 (Actual)
- Last update posted
- Dec 4, 2019
2016 – 2018
United States locations
- U.S. sites
- 59
- U.S. states
- 22
- U.S. cities
- 51
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Rheumatology Associates of North Alabama, PC | Huntsville | Alabama | 35801-4418 | — |
| Arthrocare, Arthritiscare & Research, PC | Gilbert | Arizona | 85234 | — |
| SunValley Arthritis Center, Ltd. | Peoria | Arizona | 85381 | — |
| CHI St. Vincent Medical Group Hot Springs | Hot Springs | Arkansas | 71913 | — |
| Med Investigations, Inc | Fair Oaks | California | 95628 | — |
| HCP Clinical Research, LLC | Huntington Beach | California | 92646 | — |
| Sierra Rheumatology | Roseville | California | 95661 | — |
| Pacific Arthritis Center Medical Group | Santa Maria | California | 93454 | — |
| Robin K. Dore, MD, Inc. | Tustin | California | 92780 | — |
| Inland Rheumatology and Osteoporosis Medical Group | Upland | California | 91786 | — |
| Inland Rheumatology Clinical Trials, Inc. | Upland | California | 91786 | — |
| Desert Valley Medical Group | Victorville | California | 92395 | — |
| AARDS Research Inc | Aventura | Florida | 33180 | — |
| RASF-Clinical Research Inc | Boca Raton | Florida | 33486 | — |
| Omega Research Consultants | DeBary | Florida | 32713 | — |
| University of Florida College of Medicine - Jacksonville - Rheumatology Research | Jacksonville | Florida | 32207 | — |
| University of Florida, Rheumatology at ACC | Jacksonville | Florida | 32209 | — |
| Center for Arthritis and Rheumatic Diseases | Miami | Florida | 33173 | — |
| Jeffrey Alper, MD | Naples | Florida | 34102 | — |
| Medallion Clinical Research Institute, LLC | Naples | Florida | 34102 | — |
| Suncoast Clinical Research, Inc. | New Port Richey | Florida | 34652 | — |
| Florida Arthritis & Osteoporosis Center | Port Richey | Florida | 34668 | — |
| Gulf Coast Medical Center | Port Richey | Florida | 34668 | — |
| West Broward Rheumatology Associates, Inc. | Tamarac | Florida | 33321 | — |
| USF Health Morsani Center for Advanced Healthcare | Tampa | Florida | 33612 | — |
| BayCare Medical Group, Inc | Tampa | Florida | 33614 | — |
| Institute of Arthritis Research | Idaho Falls | Idaho | 83404 | — |
| Quincy Medical Group | Quincy | Illinois | 62301 | — |
| Beacon Medical Group Rheumatology Main Street | Granger | Indiana | 46530 | — |
| Diagnostic Rheumatology and Research, PC | Indianapolis | Indiana | 46227 | — |
| Ochsner Clinic Baton Rouge | Baton Rouge | Louisiana | 70836 | — |
| Phase III Clinical Research | Fall River | Massachusetts | 02720 | — |
| Clinical Pharmacology Study Group | Worcester | Massachusetts | 01605 | — |
| Bronson Internal Medicine and Rheumatology | Battle Creek | Michigan | 49015 | — |
| Western Michigan University Homer Stryker MD | Kalamazoo | Michigan | 49007 | — |
| North Mississippi Medical Clinics, Inc. - Clinical Research | Tupelo | Mississippi | 38801 | — |
| Arthritis & Osteoporosis Associates | Freehold | New Jersey | 07728 | — |
| Radnet | Marlton | New Jersey | 08053 | — |
| Arthritis, Rheumatic & Back Disease Associates, P.A. | Voorhees Township | New Jersey | 08043 | — |
| Open MRI & Diagnostic Imaging of Wall | Wall | New Jersey | 07719 | — |
| AAIR Research Center | Rochester | New York | 14618 | — |
| Physicians East, PA | Greenville | North Carolina | 27834 | — |
| PMG Research of Salisbury | Salisbury | North Carolina | 28144 | — |
| Trinity Health Center-Medical Arts | Minot | North Dakota | 58701 | — |
| Group Health Associates | Cincinnati | Ohio | 45236 | — |
| Cincinnati Rheumatic Disease Study Group, Inc. | Cincinnati | Ohio | 45242 | — |
| STAT Research, Inc. | Dayton | Ohio | 45417 | — |
| Health Research of Oklahoma | Oklahoma City | Oklahoma | 73103 | — |
| Oklahoma Medical Research Foundation (OMRF) | Oklahoma City | Oklahoma | 73104 | — |
| Lynn Health Science Institute | Oklahoma City | Oklahoma | 73112 | — |
| East Penn Rheumatology Associates, P.C. | Bethlehem | Pennsylvania | 18015 | — |
| Altoona Center for Clinical Research | Duncansville | Pennsylvania | 16635 | — |
| Piedmont Arthritis Clinic | Greenville | South Carolina | 29601 | — |
| Articularis Healthcare Group dba ACME Research | Orangeburg | South Carolina | 29118 | — |
| Articularis Healthcare Group d/b/a Low Country Rheumatology | Summerville | South Carolina | 29486 | — |
| Pioneer Research Solutions, Inc. | Cypress | Texas | 77429 | — |
| Metroplex Clinical Research Center | Dallas | Texas | 75231 | — |
| Center for Arthritis and Rheumatic Diseases | Chesapeake | Virginia | 23320 | — |
| Center for Arthritis and Rheumatic Diseases | Suffolk | Virginia | 23435 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 77 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT02831855, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Dec 4, 2019 · Synced Oct 23, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT02831855 live on ClinicalTrials.gov.