Pivotal, Open-label, Randomized Study of Radiosurgery With or Without Tumor Treating Fields (TTFields) for 1-10 Brain Metastases From Non-small Cell Lung Cancer (NSCLC).
Public ClinicalTrials.gov record NCT02831959. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The study is a prospective, randomized controlled phase III trial, to test the efficacy, safety and neurocognitive outcomes of advanced NSCLC patients, following stereotactic radiosurgery (SRS) for 1 inoperable brain metastasis or 2-10 brain metastases, treated with NovoTTF-200M and supportive treatment compared to supportive treatment alone. The device is an experimental, portable, battery operated device for chronic administration of alternating electric fields (termed TTFields or TTF) to the region of the malignant tumor, by means of surface, insulated electrode arrays.
Study identification
- NCT ID
- NCT02831959
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 298 participants
Conditions and interventions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jul 2016 (Type not available)
- Primary completion
- Nov 29, 2024 (Actual)
- Completion
- Nov 29, 2024 (Actual)
- Last update posted
- Oct 31, 2025
2016 – 2024
United States locations
- U.S. sites
- 61
- U.S. states
- 28
- U.S. cities
- 51
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| University of Alabama at Birmingham Comprehensive Cancer Center | Birmingham | Alabama | 35233 | — |
| Grandview Medical Center - Cancer Center | Birmingham | Alabama | 35243-3326 | — |
| Infirmary Cancer Care | Mobile | Alabama | 36607 | — |
| Barrow Neurological Institute | Phoenix | Arizona | 85013-4407 | — |
| Mayo Clinic Phoenix | Phoenix | Arizona | 85054 | — |
| MemorialCare Cancer Institute | Long Beach | California | 90806 | — |
| The Center for Cancer Prevention and Treatment at St. Joseph Hospital of Orange | Orange | California | 92868 | — |
| Kaiser Permanente Redwood City | Redwood City | California | 94063 | — |
| Dignity Health - Mercy Cancer Centers | Sacramento | California | 95816 | — |
| Kaiser Permanente - Sacramento | Sacramento | California | 95825 | — |
| Sharp HealthCare | San Diego | California | 92123 | — |
| University of California | San Francisco | California | 94117 | — |
| St. Mary's Medical Center - Grand Junction | Grand Junction | Colorado | 81501 | — |
| Banner North Colorado Medical Center (NCMC) - Oncology - Greeley | Greeley | Colorado | 80631 | — |
| Banner MD Anderson Cancer Center - McKee Medical Center | Loveland | Colorado | 805838 | — |
| Baptist MD Anderson Cancer Center | Jacksonville | Florida | 32207 | — |
| UF Health Jacksonville | Jacksonville | Florida | 32209 | — |
| Mayo Clinic | Jacksonville | Florida | 32224 | — |
| Miami Cancer Institute | Miami | Florida | 33176 | — |
| Adult Oncology Research | Orlando | Florida | 32806 | — |
| UF Health Cancer Center | Orlando | Florida | 32806 | — |
| BRCR Medical Center INC | Plantation | Florida | 33324 | — |
| Piedmont Brain Tumor Center | Atlanta | Georgia | 30309 | — |
| Memorial Health University Medical Center | Savannah | Georgia | 31404-6220 | — |
| CDH-Delnor Health System | Warrenville | Illinois | 60555 | — |
| University of Kansas Cancer Center and Medical Pavilion | Kansas City | Kansas | 66160 | — |
| University of Kentucky HealthCare | Lexington | Kentucky | 40536 | — |
| University of Louisville-James Graham Brown Cancer Center | Louisville | Kentucky | 40202-5700 | — |
| Ochsner Health System | New Orleans | Louisiana | 70121 | — |
| Willis-Knighton Cancer Center | Shreveport | Louisiana | 71103 | — |
| University of Maryland | Baltimore | Maryland | 21201 | — |
| Walter Reed National Military Medical Center | Bethesda | Maryland | 20814 | — |
| Tufts Medical Center | Boston | Massachusetts | 02111 | — |
| Beth Israel Deaconess Medical Center | Boston | Massachusetts | 02215 | — |
| Karmanos Cancer Institute | Detroit | Michigan | 48201 | — |
| Abbott Northwestern Hospital - Givens Brain Tumor Center | Minneapolis | Minnesota | 55407 | — |
| John Nasseff Neuroscience Institute ANW Brain Tumor Center | Minneapolis | Minnesota | 55407 | — |
| University of Minnesota Medical Center (UMMC) - Fairview - Masonic Cancer Clinic | Minneapolis | Minnesota | 55455-0341 | — |
| University of Mississippi Medical Center | Jackson | Mississippi | 39216 | — |
| Ellis Fischel Cancer Center, University of Missouri Healthcare | Columbia | Missouri | 65212 | — |
| Oncology Research | Mercy Research | St Louis | Missouri | 63141 | — |
| Renown Regional Medical Center | Reno | Nevada | 89502 | — |
| MD Anderson Cancer Center at Cooper | Camden | New Jersey | 08103 | — |
| UNC - Lineberger Comprehensive Cancer Center | Chapel Hill | North Carolina | 27599 | — |
| Vidant Medical Center | Greenville | North Carolina | 27834 | — |
| Wake Forest University Baptist Medical Center (WFUBMC) - Comprehensive Cancer Center | Winston-Salem | North Carolina | 27157-0001 | — |
| Cleveland Clinic | Cleveland | Ohio | 44195 | — |
| Providence St. Vincent Medical Center | Portland | Oregon | 97225 | — |
| Geisinger Medical Center | Danville | Pennsylvania | 17822 | — |
| Rhode Island Hospital | Providence | Rhode Island | 02903 | — |
| Medical University of South Carolina- Hollings Cancer Center | Charleston | South Carolina | 29425-8900 | — |
| Prisma Health - Upstate | Greenville | South Carolina | 29605 | — |
| Erlanger Baroness Hospital | Chattanooga | Tennessee | 37403 | — |
| West Cancer Center | Germantown | Tennessee | 38138 | — |
| Mischer Neuroscience Associates - Texas Medical Center | Houston | Texas | 77030-1536 | — |
| Houston Methodist Hospital | Houston | Texas | 77030 | — |
| Texas Oncology | McKinney | Texas | 75701 | — |
| Texas Oncology | Plano | Texas | 75093 | — |
| Baylor Scott & White Medical Center - Temple | Waco | Texas | 76712-8897 | — |
| University of Washington Medical Center | Seattle | Washington | 98195 | — |
| Aurora Research Institute | Milwaukee | Wisconsin | 53215-5221 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 67 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT02831959, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Oct 31, 2025 · Synced Oct 30, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT02831959 live on ClinicalTrials.gov.