A Study of Zenocutuzumab (MCLA-128) in Patients With Solid Tumors Harboring an NRG1 Fusion (eNRGy)
Public ClinicalTrials.gov record NCT02912949. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase I/II Study of MCLA-128, a Full Length IgG1 Bispecific Antibody Targeting HER2 and HER3, in Patients With Solid Tumors (eNRGy)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This is a Phase I/II, open-label, multi-center, multi-national, dose escalation, single agent study to assess the safety, tolerability, PK, PD, immunogenicity and anti-tumor activity of zenocutuzumab (MCLA-128) in patients with solid tumors harboring an NRG1 fusion (eNRGy)
Study identification
- NCT ID
- NCT02912949
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 250 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jan 2015 (Actual)
- Primary completion
- Dec 31, 2026 (Estimated)
- Completion
- Dec 31, 2026 (Estimated)
- Last update posted
- Apr 29, 2025
2015 – 2026
United States locations
- U.S. sites
- 26
- U.S. states
- 17
- U.S. cities
- 24
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Mayo Clinic | Phoenix | Arizona | — | — |
| The Oncology Institute of Hope and Innovation | Cerritos | California | — | — |
| University of California Irvine | Irvine | California | — | — |
| Stanford University | Palo Alto | California | — | — |
| Sharp Memorial Hospital | San Diego | California | — | — |
| Georgetown University | Washington D.C. | District of Columbia | — | — |
| Memorial Cancer Institute | Hollywood | Florida | — | — |
| Cancer Specialists of North Florida | Jacksonville | Florida | — | — |
| Mayo Clinic | Jacksonville | Florida | — | — |
| Emory Winship Cancer Institute | Atlanta | Georgia | — | — |
| Northwest Oncology & Hematology | Rolling Meadows | Illinois | — | — |
| Dana Farber Cancer Center | Boston | Massachusetts | — | — |
| Karmanos Cancer Center | Detroit | Michigan | 48201 | — |
| Mayo Clinic | Rochester | Minnesota | — | — |
| Billings Clinic Cancer Center | Billings | Montana | — | — |
| St. James Healthcare | Butte | Montana | — | — |
| Memorial Sloan Kettering Cancer Center | New York | New York | — | — |
| University of Pennsylvania | Philadelphia | Pennsylvania | — | — |
| Averra Medical Group | Sioux Falls | South Dakota | — | — |
| The University of Texas MD Anderson Cancer Center | Houston | Texas | — | — |
| Huntsman Cancer Institute | Salt Lake City | Utah | — | — |
| Utah Cancer Specialists | Salt Lake City | Utah | — | — |
| Hematology-Oncology Specialist of Fredericksburg | Fredericksburg | Virginia | — | — |
| Virginia Mason Hospital & Seattle Medical Center | Seattle | Washington | — | — |
| Hematology Oncology Associates | Spokane | Washington | — | — |
| Northwest Medical Specialties | Tacoma | Washington | — | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 38 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT02912949, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Apr 29, 2025 · Synced Oct 23, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT02912949 live on ClinicalTrials.gov.