Prospective ARNI vs ACE Inhibitor Trial to DetermIne Superiority in Reducing Heart Failure Events After MI
Public ClinicalTrials.gov record NCT02924727. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Multi-center, Randomized, Double-blind, Active-controlled, Parallel-group Phase 3 Study to Evaluate the Efficacy and Safety of LCZ696 Compared to Ramipril on Morbidity and Mortality in High Risk Patients Following an Acute Myocardial Infarction (AMI)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The purpose of this study is to evaluate the efficacy and safety of LCZ696 titrated to a target dose of 200 mg twice daily, compared to ramipril titrated to a target dose of 5 mg twice daily.
Study identification
- NCT ID
- NCT02924727
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 5,669 participants
Conditions and interventions
Conditions
Interventions
- LCZ696 (sacubitril/valsartan) Drug
- Ramipril Drug
- Placebo of LCZ696 Drug
- Placebo of ramipril Drug
- Valsartan Drug
- Placebo of valsartan Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Dec 9, 2016 (Actual)
- Primary completion
- Feb 26, 2021 (Actual)
- Completion
- Feb 26, 2021 (Actual)
- Last update posted
- Jun 22, 2023
2016 – 2021
United States locations
- U.S. sites
- 81
- U.S. states
- 30
- U.S. cities
- 77
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Novartis Investigative Site | Birmingham | Alabama | 35243 | — |
| Novartis Investigative Site | Birmingham | Alabama | 35294-2041 | — |
| Novartis Investigative Site | Huntsville | Alabama | 35801 | — |
| Novartis Investigative Site | Gilbert | Arizona | 85297 | — |
| Novartis Investigative Site | Bakersfield | California | 93301 | — |
| Novartis Investigative Site | Carmichael | California | 95608 | — |
| Novartis Investigative Site | Los Alamitos | California | 90720 | — |
| Novartis Investigative Site | Northridge | California | 91325 | — |
| Novartis Investigative Site | Orange | California | 92868 | — |
| Novartis Investigative Site | San Francisco | California | 94143 | — |
| Novartis Investigative Site | Sylmar | California | 91342 | — |
| Novartis Investigative Site | Brandon | Florida | 33511 | — |
| Novartis Investigative Site | Hollywood | Florida | 33312 | — |
| Novartis Investigative Site | Jacksonville Beach | Florida | 32050 | — |
| Novartis Investigative Site | Ocala | Florida | 34480 | — |
| Novartis Investigative Site | Cumming | Georgia | 30041 | — |
| Novartis Investigative Site | Johns Creek | Georgia | 30024 | — |
| Novartis Investigative Site | Thomasville | Georgia | 31792 | — |
| Novartis Investigative Site | Boise | Idaho | 83702 | — |
| Novartis Investigative Site | Coeur d'Alene | Idaho | 83814 | — |
| Novartis Investigative Site | Muncie | Indiana | 47303-3400 | — |
| Novartis Investigative Site | Munster | Indiana | 46321 | — |
| Novartis Investigative Site | Richmond | Indiana | 47374 | — |
| Novartis Investigative Site | Iowa City | Iowa | 52242 | — |
| Novartis Investigative Site | Alexandria | Louisiana | 71301 | — |
| Novartis Investigative Site | Baton Rouge | Louisiana | 70808 | — |
| Novartis Investigative Site | Covington | Louisiana | 70433 | — |
| Novartis Investigative Site | Hammond | Louisiana | 70403 | — |
| Novartis Investigative Site | Slidell | Louisiana | 70458 | — |
| Novartis Investigative Site | Bangor | Maine | 04401 | — |
| Novartis Investigative Site | Baltimore | Maryland | 21201 | — |
| Novartis Investigative Site | Baltimore | Maryland | 21218 | — |
| Novartis Investigative Site | Rockville | Maryland | 20850 | — |
| Novartis Investigative Site | Detroit | Michigan | 48201 | — |
| Novartis Investigative Site | Kalamazoo | Michigan | 49008 | — |
| Novartis Investigative Site | Lansing | Michigan | 48912 | — |
| Novartis Investigative Site | Petoskey | Michigan | 49770 | — |
| Novartis Investigative Site | Saginaw | Michigan | 48601 | — |
| Novartis Investigative Site | Southfield | Michigan | 48075 | — |
| Novartis Investigative Site | Duluth | Minnesota | 55805 | — |
| Novartis Investigative Site | Robbinsdale | Minnesota | 55422 | — |
| Novartis Investigative Site | Saint Cloud | Minnesota | 56303 | — |
| Novartis Investigative Site | Saint Paul | Minnesota | 55101 | — |
| Novartis Investigative Site | Hattiesburg | Mississippi | 39401 | — |
| Novartis Investigative Site | Jackson | Mississippi | 39216 | — |
| Novartis Investigative Site | Lee's Summit | Missouri | 64064 | — |
| Novartis Investigative Site | North Kansas City | Missouri | 64116 | — |
| Novartis Investigative Site | Springfield | Missouri | 65804 | — |
| Novartis Investigative Site | Lincoln | Nebraska | 68506 | — |
| Novartis Investigative Site | Lincoln | Nebraska | 68526 | — |
| Novartis Investigative Site | Omaha | Nebraska | 68114 | — |
| Novartis Investigative Site | Lebanon | New Hampshire | 03756 | — |
| Novartis Investigative Site | Hackensack | New Jersey | 07601 | — |
| Novartis Investigative Site | Flushing | New York | 11355 | — |
| Novartis Investigative Site | New York | New York | 10016 | — |
| Novartis Investigative Site | New York | New York | 10029 | — |
| Novartis Investigative Site | Valhalla | New York | 10595 | — |
| Novartis Investigative Site | Chapel Hill | North Carolina | 27599 | — |
| Novartis Investigative Site | Charlotte | North Carolina | 28204 | — |
| Novartis Investigative Site | Durham | North Carolina | 27710 | — |
| Novartis Investigative Site | Grand Forks | North Dakota | 58201 | — |
| Novartis Investigative Site | Canton | Ohio | 44710 | — |
| Novartis Investigative Site | Cincinnati | Ohio | 45220 | — |
| Novartis Investigative Site | Medford | Oregon | 97504 | — |
| Novartis Investigative Site | Erie | Pennsylvania | 16550 | — |
| Novartis Investigative Site | Hershey | Pennsylvania | 17033 | — |
| Novartis Investigative Site | York | Pennsylvania | 17403 | — |
| Novartis Investigative Site | Charleston | South Carolina | 29403 | — |
| Novartis Investigative Site | Columbia | South Carolina | 29203 | — |
| Novartis Investigative Site | Greenville | South Carolina | 29607 | — |
| Novartis Investigative Site | Rapid City | South Dakota | 57701 | — |
| Novartis Investigative Site | Knoxville | Tennessee | 37917 | — |
| Novartis Investigative Site | Nashville | Tennessee | 37212 | — |
| Novartis Investigative Site | Dallas | Texas | 75226 | — |
| Novartis Investigative Site | Houston | Texas | 77030 | — |
| Novartis Investigative Site | Webster | Texas | 77598 | — |
| Novartis Investigative Site | Danville | Virginia | 24541 | — |
| Novartis Investigative Site | Falls Church | Virginia | 22042 | — |
| Novartis Investigative Site | Lynchburg | Virginia | 24501 | — |
| Novartis Investigative Site | Manassas | Virginia | 20109 | — |
| Novartis Investigative Site | Bellevue | Washington | 98004 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 405 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT02924727, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jun 22, 2023 · Synced Oct 20, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT02924727 live on ClinicalTrials.gov.