Lenvatinib and Pembrolizumab in Differentiated Thyroid Cancers (DTC)
Public ClinicalTrials.gov record NCT02973997. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
Combination Targeted Therapy With Pembrolizumab and Lenvatinib in Progressive, Radioiodine-Refractory Differentiated Thyroid Cancers: A Phase II Study
Study identification
- NCT ID
- NCT02973997
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2
- Lead sponsor
- Academic and Community Cancer Research United
- Other
- Enrollment
- 57 participants
Conditions and interventions
Conditions
- Columnar Cell Variant Thyroid Gland Papillary Carcinoma
- Follicular Variant Thyroid Gland Papillary Carcinoma
- Metastatic Thyroid Gland Follicular Carcinoma
- Metastatic Thyroid Gland Papillary Carcinoma
- Poorly Differentiated Thyroid Gland Carcinoma
- Recurrent Differentiated Thyroid Gland Carcinoma
- Recurrent Thyroid Gland Follicular Carcinoma
- Recurrent Thyroid Gland Papillary Carcinoma
- Stage III Differentiated Thyroid Gland Carcinoma AJCC v7
- Stage III Thyroid Gland Follicular Carcinoma AJCC v7
- Stage III Thyroid Gland Papillary Carcinoma AJCC v7
- Stage IV Thyroid Gland Follicular Carcinoma AJCC v7
- Stage IV Thyroid Gland Papillary Carcinoma AJCC v7
- Stage IVA Differentiated Thyroid Gland Carcinoma AJCC v7
- Stage IVA Thyroid Gland Follicular Carcinoma AJCC v7
- Stage IVA Thyroid Gland Papillary Carcinoma AJCC v7
- Stage IVB Differentiated Thyroid Gland Carcinoma AJCC v7
- Stage IVB Thyroid Gland Follicular Carcinoma AJCC v7
- Stage IVB Thyroid Gland Papillary Carcinoma AJCC v7
- Stage IVC Differentiated Thyroid Gland Carcinoma AJCC v7
- Stage IVC Thyroid Gland Follicular Carcinoma AJCC v7
- Stage IVC Thyroid Gland Papillary Carcinoma AJCC v7
- Tall Cell Variant Thyroid Gland Papillary Carcinoma
- Thyroid Gland Hurthle Cell Carcinoma
- Unresectable Differentiated Thyroid Gland Carcinoma
- Unresectable Thyroid Gland Carcinoma
Interventions
- Laboratory Biomarker Analysis Other
- Lenvatinib Drug
- Lenvatinib Mesylate Drug
- Pembrolizumab Biological
Other · Drug · Biological
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Feb 6, 2018
- Primary completion
- Aug 14, 2022
- Completion
- Oct 7, 2023
- Last update posted
- Aug 28, 2025
2018 – 2023
United States locations
- U.S. sites
- 7
- U.S. states
- 7
- U.S. cities
- 7
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center | Torrance | California | 90502 | — |
| University of Colorado Hospital | Aurora | Colorado | 80045 | — |
| Massachusetts General Hospital Cancer Center | Boston | Massachusetts | 02114 | — |
| University of Michigan Comprehensive Cancer Center | Ann Arbor | Michigan | 48109 | — |
| Memorial Sloan Kettering Cancer Center | New York | New York | 10065 | — |
| Ohio State University Comprehensive Cancer Center | Columbus | Ohio | 43210 | — |
| M D Anderson Cancer Center | Houston | Texas | 77030 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT02973997, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Aug 28, 2025 · Synced May 20, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT02973997 live on ClinicalTrials.gov.