NATIENS: Optimal Management and Mechanisms of SJS/TEN
Public ClinicalTrials.gov record NCT02987257. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
NATIENS: A Phase III Randomized Double-Blinded Placebo Controlled Study to Determine the Optimal Management and Mechanisms of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The North American Therapeutics in Epidermal Necrolysis Syndrome (NATIENS) study is a multicenter double-blind randomized controlled assessment of two arms - one of systemic immunomodulatory therapy (etanercept) and one of supportive care deemed to be the current standard of care. We will leverage the opportunity of this controlled design to collect multiples samples with an aim to discover new genetic and biological markers for prevention and early diagnosis and define cellular and molecular mechanisms to facilitate discovery of promising treatment strategies. This study has been preceded by a planning phase to ensure testing and development of harmonized supportive care infrastructure and operating procedures across sites.
Study identification
- NCT ID
- NCT02987257
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 2 participants
Conditions and interventions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Mar 20, 2023
- Primary completion
- Oct 30, 2025
- Completion
- Oct 30, 2025
- Last update posted
- Dec 16, 2025
2023 – 2025
United States locations
- U.S. sites
- 14
- U.S. states
- 11
- U.S. cities
- 14
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Valleywise Health Medical Center | Phoenix | Arizona | 85008 | — |
| University of California, Davis Medical Center | Sacramento | California | 95817 | — |
| MedStar Washington Hospital Center | Washington D.C. | District of Columbia | 20010 | — |
| University of Florida Health Burn Center | Gainesville | Florida | 32610 | — |
| University of Miami, Ryder Trauma Center | Miami | Florida | 33136 | — |
| Emory University at Grady Memorial Hospital | Atlanta | Georgia | 30303 | — |
| Loyola University Medical Center | Maywood | Illinois | 60153 | — |
| Johns Hopkins Bayview Medical Center | Baltimore | Maryland | 21224 | — |
| Wayne State University | Detroit | Michigan | 48201 | — |
| University of Tennessee Health Sciences Center | Memphis | Tennessee | 38103 | — |
| Vanderblt University Medical Center | Nashville | Tennessee | 37232 | — |
| University of Texas Southwestern Medical Center | Dallas | Texas | 75390 | — |
| University of Texas Medical Branch | Galveston | Texas | 77555 | — |
| University of Washington, Harborview Medical Center | Seattle | Washington | 98104 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT02987257, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Dec 16, 2025 · Synced Sep 8, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT02987257 live on ClinicalTrials.gov.