Phase 1/2 Study of the Highly-selective RET Inhibitor, Pralsetinib (BLU-667), in Participants With Thyroid Cancer, Non-Small Cell Lung Cancer, and Other Advanced Solid Tumors
Public ClinicalTrials.gov record NCT03037385. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 1/2 Study of the Highly-selective RET Inhibitor, BLU-667, in Patients With Thyroid Cancer, Non-Small Cell Lung Cancer (NSCLC) and Other Advanced Solid Tumors
Study identification
- NCT ID
- NCT03037385
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 1, Phase 2
- Lead sponsor
- Hoffmann-La Roche
- Industry
- Enrollment
- 590 participants
Conditions and interventions
Conditions
- Adenocarcinoma
- Adenocarcinoma, Papillary
- Bronchial Neoplasms
- Carcinoma
- Carcinoma, Bronchogenic
- Carcinoma, Neuroendocrine
- Carcinoma, Non-Small-Cell Lung
- Colonic Diseases
- Colonic Neoplasms
- Colorectal Neoplasms
- Digestive System Disease
- Digestive System Neoplasm
- Endocrine Gland Neoplasm
- Endocrine System Diseases
- Gastrointestinal Disease
- Gastrointestinal Neoplasms
- Head and Neck Neoplasms
- Intestinal Disease
- Intestinal Neoplasms
- Lung Diseases
- Lung Neoplasm
- Medullary Thyroid Cancer
- Neoplasms
- Neoplasms by Histologic Type
- Neoplasms by Site
- Neoplasms, Germ Cell and Embryonal
- Neoplasms, Glandular and Epithelial
- Neoplasms, Nerve Tissue
- Neuroectodermal Tumors
- Neuroendocrine Tumors
- RET-altered Colon Cancer
- RET-altered Non Small Cell Lung Cancer
- RET-altered Papillary Thyroid Cancer
- RET-altered Solid Tumors
- Respiratory Tract Disease
- Respiratory Tract Neoplasms
- Thoracic Neoplasms
- Thyroid Cancer, Papillary
- Thyroid Diseases
- Thyroid Neoplasm
Interventions
- pralsetinib (BLU-667) Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Mar 16, 2017
- Primary completion
- Mar 20, 2024
- Completion
- Mar 20, 2024
- Last update posted
- May 30, 2025
2017 – 2024
United States locations
- U.S. sites
- 18
- U.S. states
- 14
- U.S. cities
- 18
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Mayo Clinic Hospital | Phoenix | Arizona | 85054 | — |
| UC Irvine Medical Center | Orange | California | 92868 | — |
| University of Colorado Anschutz Medical Campus | Aurora | Colorado | 80045 | — |
| Georgetown University Medical Center | Washington D.C. | District of Columbia | 20007 | — |
| Mayo Clinic-Jacksonville | Jacksonville | Florida | 32224 | — |
| Sylvester Comprehensive Cancer Center | Miami | Florida | 33136-1002 | — |
| Maryland Oncology Hematology, P.A. | Columbia | Maryland | 21044-3257 | — |
| Massachusetts General Hospital. | Boston | Massachusetts | 02114-2696 | — |
| University of Michigan | Ann Arbor | Michigan | 48109-0934 | — |
| Mayo Clinic Rochester | Rochester | Minnesota | 55902-3003 | — |
| Washington University School of Medicine in St. Louis | St Louis | Missouri | 63110-1010 | — |
| Albany Medical Center | Albany | New York | 12208-3412 | — |
| Weill Cornell Medical College-New York Presbyterian Hospital | New York | New York | 10021 | — |
| Oregon Health & Science University | Portland | Oregon | 97239 | — |
| Texas Oncology-Austin Midtown | Austin | Texas | 78705-1165 | — |
| Texas Oncology - Baylor Charles A. Sammons Cancer Center | Dallas | Texas | 75246 | — |
| The University of Texas MD Anderson Cancer Center | Houston | Texas | 77030-4000 | — |
| Seattle Cancer Care Alliance | Seattle | Washington | 98109 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 53 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT03037385, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted May 30, 2025 · Synced May 19, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT03037385 live on ClinicalTrials.gov.