A Study of Repotrectinib (TPX-0005) in Patients With Advanced Solid Tumors Harboring ALK, ROS1, or NTRK1-3 Rearrangements

ClinicalTrials.gov ID: NCT03093116

Public ClinicalTrials.gov record NCT03093116. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced May 20, 2026, 3:53 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Phase 1/2, Open-Label, Multi-Center, First-in-Human Study of the Safety, Tolerability, Pharmacokinetics, and Anti-Tumor Activity of TPX-0005 in Patients With Advanced Solid Tumors Harboring ALK, ROS1, or NTRK1-3 Rearrangements (TRIDENT-1)

Study identification

NCT ID: NCT03093116
Recruitment status: Recruiting
Study type: Interventional
Phase: Phase 1, Phase 2
Lead sponsor: Turning Point Therapeutics, Inc.; Industry
Enrollment: 500 participants

Conditions and interventions

Conditions

Interventions

Oral repotrectinib (TPX-0005) Drug

Drug

Eligibility (public fields only)

Age range: 12 Years and older
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Mar 6, 2017
Primary completion: Feb 28, 2028
Completion: Feb 28, 2028
Last update posted: Apr 2, 2026

2017 – 2028

United States locations

U.S. sites: 49
U.S. states: 22
U.S. cities: 39

Facility	City	State	ZIP	Site status
Local Institution - 2129	Duarte	California	91010	Completed
Local Institution - 2120	Glendale	California	91206	Completed
Local Institution - 2136	La Jolla	California	92037	Withdrawn
Local Institution - 2114	La Jolla	California	92093	Completed
Local Institution - 2121	Long Beach	California	90813	Completed
Local Institution - 1001	Orange	California	92868	Completed
Local Institution - 2101	Orange	California	92868	Completed
St Joseph Heritage Healthcare	Santa Rosa	California	95403	Recruiting
Local Institution - 1003	Aurora	Colorado	80045	Completed
Local Institution - 2103	Aurora	Colorado	80045	Completed
Local Institution - 2106	Washington D.C.	District of Columbia	20007	Completed
Local Institution - 2110	Washington D.C.	District of Columbia	20016	Completed
Memorial Healthcare System	Hollywood	Florida	33021	Recruiting
Local Institution - 2113	Tampa	Florida	33612	Completed
University Cancer and Blood Center	Athens	Georgia	30607	Recruiting
Local Institution - 2134	Columbus	Georgia	31904	Completed
University of Chicago	Chicago	Illinois	60637	Recruiting
Local Institution - 2142	Peoria	Illinois	61615	Completed
Local Institution - 2116	New Orleans	Louisiana	70121	Not yet recruiting
Local Institution - 2133	Baltimore	Maryland	21210	Completed
Massachusetts General Hospital,	Boston	Massachusetts	02114	Recruiting
Local Institution - 1004	Boston	Massachusetts	02214	Completed
Local Institution - 2131	Boston	Massachusetts	02215	Completed
Local Institution - 2105	Ann Arbor	Michigan	48109	Completed
Local Institution - 2111	Detroit	Michigan	48201	Completed
Local Institution - 2140	Detroit	Michigan	48202-2608	Completed
Local Institution - 2132	Saint Paul	Minnesota	55101	Completed
Local Institution - 2147	Bolivar	Missouri	65613	Completed
Washington University Infusion Center Pharmacy	St Louis	Missouri	63110	Recruiting
Local Institution - 2122	New Brunswick	New Jersey	08901	Completed
Local Institution - 2117	New York	New York	10016	Completed
Local Institution - 1002	New York	New York	10065	Active, not recruiting
Local Institution - 2102	New York	New York	10065	Completed
Local Institution - 2144	Goldsboro	North Carolina	27534	Completed
Local Institution - 2112	Canton	Ohio	44718	Completed
Local Institution - 2143	Cincinnati	Ohio	45220	Completed
Local Institution - 2109	Cleveland	Ohio	44195	Completed
The Ohio State University Wexner Medical Center	Columbus	Ohio	43210	Recruiting
Local Institution - 2119	Toledo	Ohio	43614	Completed
Local Institution - 2108	Philadelphia	Pennsylvania	19111-2497	Completed
Baptist Memorial Hospital Baptist Cancer Center	Memphis	Tennessee	38120	Recruiting
UT Southwestern Medical Center	Dallas	Texas	75390	Recruiting
Local Institution - 2127	Houston	Texas	77030	Completed
MD Anderson Cancer Center	Houston	Texas	77030	Recruiting
Local Institution - 2146	Kingwood	Texas	77339	Completed
Local Institution - 2137	Fairfax	Virginia	22031	Completed
Local Institution - 2107	Seattle	Washington	98109	Completed
Local Institution - 2141	Tacoma	Washington	98405	Withdrawn
Local Institution - 2145	Appleton	Wisconsin	54911	Completed

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 114 non-U.S. sites.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT03093116, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted Apr 2, 2026 · Synced May 20, 2026

Open the official record

The complete protocol, eligibility criteria, and contact information for NCT03093116 live on ClinicalTrials.gov.

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