A Study of Crenezumab Versus Placebo to Evaluate the Efficacy and Safety in Participants With Prodromal to Mild Alzheimer's Disease (AD)
Public ClinicalTrials.gov record NCT03114657. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase III, Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, Efficacy and Safety Study of Crenezumab in Patients With Prodromal to Mild Alzheimer's Disease
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This randomized, double-blind, placebo-controlled, parallel-group study will evaluate the efficacy and safety of crenezumab versus placebo in participants with prodromal to mild AD. Participants will be randomized 1:1 to receive either intravenous (IV) infusion of crenezumab or placebo every 4 weeks (Q4W) for 100 weeks. The primary efficacy assessment will be performed at 105 weeks. The participants who do not enter open-label extension will enter for a long term follow-up period for up to 52 weeks after the last crenezumab dose (Week 153).
Study identification
- NCT ID
- NCT03114657
- Recruitment status
- Terminated
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 806 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 50 Years to 85 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Mar 29, 2017 (Actual)
- Primary completion
- Jun 11, 2019 (Actual)
- Completion
- Jun 11, 2019 (Actual)
- Last update posted
- Jul 16, 2020
2017 – 2019
United States locations
- U.S. sites
- 48
- U.S. states
- 23
- U.S. cities
- 47
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Imaging End Points Clinical Research | Scottsdale | Arizona | 85258 | — |
| Health Initiatives Research, PLLC | Fayetteville | Arkansas | 72703 | — |
| Clinical Trials Inc. | Little Rock | Arkansas | 72205 | — |
| Neuro-Therapeutics Inc. | Pasadena | California | 91105 | — |
| Desert Valley Medical Group | Rancho Mirage | California | 92270 | — |
| Anderson Clinical Research, Inc. | Redlands | California | 92374 | — |
| University of California, Davis; Alzheimers Disease Center, Department of Neurology | Sacramento | California | 95817 | — |
| UCSF - Memory and Aging Center | San Francisco | California | 94158 | — |
| MCB Clinical Research Centers | Colorado Springs | Colorado | 80910 | — |
| Research Center for Clinical Studies, Inc. | Norwalk | Connecticut | 06851 | — |
| KI Health Partners, LLC; New England Institute for Clinical Research | Stamford | Connecticut | 06905 | — |
| Georgetown University Hospital | Washington D.C. | District of Columbia | 20057 | — |
| JEM Research LLC | Atlantis | Florida | 33462 | — |
| Bradenton Research Center | Bradenton | Florida | 34205 | — |
| Neuropsychiatric Research; Center of Southwest Florida | Fort Myers | Florida | 33912 | — |
| Alzheimer's Research and Treatment Center | Lake Worth | Florida | 33414 | — |
| Renstar Medical Research | Ocala | Florida | 34470 | — |
| Bioclinica Research | Orlando | Florida | 32806 | — |
| Progressive Medical Research | Port Orange | Florida | 32127 | — |
| Columbus Memory Center | Columbus | Georgia | 31909 | — |
| Lake Charles Clinical Trials, LLC | Lake Charles | Louisiana | 70601 | — |
| Alzheimers Disease Center; Neurology | Winchester | Massachusetts | 01890 | — |
| Health Partners Institute for Education and Research | Saint Paul | Minnesota | 55130 | — |
| Precise Research Centers | Flowood | Mississippi | 39232 | — |
| University of Nebraska Medical Center; Dept of Neurological Sciences | Omaha | Nebraska | 68198-8440 | — |
| Cleveland Clinic Lou Ruvo; Center for Brain Research | Las Vegas | Nevada | 89106 | — |
| The Cognitive and Research Center of New Jersey | Summit | New Jersey | 07081 | — |
| Advanced Memory Research Institute of NJ | Toms River | New Jersey | 08755 | — |
| Columbia University Medical Center | New York | New York | 10032 | — |
| Burke Rehabilitation Hospital | White Plains | New York | 10605 | — |
| Behavioral Health Research | Charlotte | North Carolina | 28211 | — |
| Wake Research Associates | Raleigh | North Carolina | 27612 | — |
| University of Cincinnati; Department of Psychiatry and Behavioral Neuroscience | Cincinnati | Ohio | 45219 | — |
| Ohio State University; College of Medicine | Columbus | Ohio | 43210 | — |
| Dayton Center for Neuro Disorders | Dayton | Ohio | 45459 | — |
| Summit Research Network Inc. | Portland | Oregon | 97210 | — |
| Thomas Jefferson University | Philadelphia | Pennsylvania | 19107 | — |
| Northeastern Pennsylvania Memory | Plains | Pennsylvania | 18705 | — |
| Abington Neurological Associates | Willow Grove | Pennsylvania | 19090 | — |
| Neurology Clinic PC | Cordova | Tennessee | 38018 | — |
| Senior Adults Specialty Research | Austin | Texas | 78757 | — |
| Gadolin Research, LLC | Beaumont | Texas | 77702 | — |
| Texas Neurology PA | Dallas | Texas | 75214 | — |
| Kerwin Research Center, LLC | Dallas | Texas | 75231 | — |
| Alzheimers Disease & Memory Disorders Center; Department of Neurology Baylor College of Medicine | Houston | Texas | 77030 | — |
| Clinical Trials of Texas, Inc | San Antonio | Texas | 78229 | — |
| Sentara Medical Group | Norfolk | Virginia | 23507 | — |
| National Clinical Research Inc.-Richmond | Richmond | Virginia | 23294 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 163 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT03114657, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jul 16, 2020 · Synced Oct 28, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT03114657 live on ClinicalTrials.gov.