A Study of Nivolumab Combined With Cabozantinib Compared to Sunitinib in Previously Untreated Advanced or Metastatic Renal Cell Carcinoma
Public ClinicalTrials.gov record NCT03141177. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 3, Randomized, Open-Label Study of Nivolumab Combined With Cabozantinib Versus Sunitinib in Participants With Previously Untreated Advanced or Metastatic Renal Cell Carcinoma
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The purpose of this study is to determine whether Nivolumab Combined with Cabozantinib is safe and effective compared to Sunitinib in previously untreated advanced or metastatic renal cell carcinoma
Study identification
- NCT ID
- NCT03141177
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 701 participants
Conditions and interventions
Conditions
Interventions
- Nivolumab Biological
- Cabozantinib Drug
- Sunitinib Drug
- Ipilimumab Biological
Biological · Drug
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jul 23, 2017 (Actual)
- Primary completion
- Feb 12, 2020 (Actual)
- Completion
- Apr 1, 2026 (Actual)
- Last update posted
- Aug 24, 2026
2017 – 2026
United States locations
- U.S. sites
- 30
- U.S. states
- 17
- U.S. cities
- 29
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Local Institution - 0077 | Daphne | Alabama | 36526 | — |
| Local Institution - 0044 | Goodyear | Arizona | 85338 | — |
| Local Institution - 0132 | Tucson | Arizona | 85724-5024 | — |
| Local Institution - 0133 | Bakersfield | California | 93309 | — |
| Local Institution - 0093 | Los Angeles | California | 90404 | — |
| Local Institution - 0090 | Redondo Beach | California | 90277 | — |
| Local Institution - 0088 | San Luis Obispo | California | 93401 | — |
| Central Coast Medical Oncology Corporation | Santa Maria | California | 93454 | — |
| Local Institution - 0103 | Aurora | Colorado | 80045 | — |
| Local Institution - 0127 | Athens | Georgia | 30607 | — |
| Local Institution - 0086 | Newnan | Georgia | 30265 | — |
| Local Institution - 0036 | Chicago | Illinois | 60612 | — |
| Local Institution - 0042 | Zion | Illinois | 60099 | — |
| Local Institution - 0091 | Fort Wayne | Indiana | 46804 | — |
| Local Institution - 0087 | Wichita | Kansas | 67214 | — |
| Local Institution - 0113 | Boston | Massachusetts | 02114 | — |
| Local Institution - 0037 | Boston | Massachusetts | 02215 | — |
| Local Institution - 0106 | Kansas City | Missouri | 64132 | — |
| Local Institution - 0035 | St Louis | Missouri | 63110 | — |
| Local Institution - 0102 | Las Vegas | Nevada | 89169 | — |
| Local Institution - 0040 | Buffalo | New York | 14263 | — |
| Local Institution - 0017 | New York | New York | 10065 | — |
| Local Institution - 0067 | Portland | Oregon | 97239 | — |
| Local Institution - 0135 | Allentown | Pennsylvania | 18103 | — |
| Local Institution - 0105 | Nashville | Tennessee | 37203 | — |
| Local Institution - 0080 | Austin | Texas | 78705 | — |
| Local Institution - 0075 | Dallas | Texas | 75246 | — |
| Local Institution - 0068 | Houston | Texas | 77030 | — |
| Local Institution - 0078 | Sherman | Texas | 75090 | — |
| Local Institution - 0131 | Norfolk | Virginia | 23502 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 105 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT03141177, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Aug 24, 2026 · Synced Oct 19, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT03141177 live on ClinicalTrials.gov.