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Completed Phase 2 Interventional Results available

Trametinib in Treating Patients With Epithelioid Hemangioendothelioma That is Metastatic, Locally Advanced, or Cannot Be Removed by Surgery

ClinicalTrials.gov ID: NCT03148275

Public ClinicalTrials.gov record NCT03148275. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

ClinicalTrials.gov public records Last synced Oct 25, 2026, 7:56 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Non-Randomized, Open-Label, Phase 2 Study of Trametinib in Patients With Unresectable or Metastatic Epithelioid Hemangioendothelioma

Brief summary

Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.

This phase II trial studies how well trametinib works in treating patients with epithelioid hemangioendothelioma that has spread to other places in the body (metastatic), nearby tissue or lymph nodes (locally advanced), or cannot be removed by surgery (unresectable). Trametinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth.

Study identification

NCT ID
NCT03148275
Recruitment status
Completed
Study type
Interventional
Phase
Phase 2
Enrollment
44 participants

Conditions and interventions

Eligibility (public fields only)

Age range
15 Years and older
Sex
All
Healthy volunteers
Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date
Jun 20, 2017 (Actual)
Primary completion
Jun 23, 2023 (Actual)
Completion
Jun 23, 2023 (Actual)
Last update posted
Nov 26, 2024

2017 – 2023

United States locations

U.S. sites
36
U.S. states
20
U.S. cities
27
Facility City State ZIP Site status
Mayo Clinic Hospital in Arizona Phoenix Arizona 85054 —
Mayo Clinic in Arizona Scottsdale Arizona 85259 —
Stanford Cancer Institute Palo Alto Palo Alto California 94304 —
UCHealth University of Colorado Hospital Aurora Colorado 80045 —
Smilow Cancer Center/Yale-New Haven Hospital New Haven Connecticut 06510 —
Yale University New Haven Connecticut 06520 —
Mayo Clinic in Florida Jacksonville Florida 32224-9980 —
Northwestern University Chicago Illinois 60611 —
University of Kansas Clinical Research Center Fairway Kansas 66205 —
Johns Hopkins University/Sidney Kimmel Cancer Center Baltimore Maryland 21287 —
Massachusetts General Hospital Cancer Center Boston Massachusetts 02114 —
Brigham and Women's Hospital Boston Massachusetts 02115 —
Beth Israel Deaconess Medical Center Boston Massachusetts 02215 —
Dana-Farber Cancer Institute Boston Massachusetts 02215 —
University of Michigan Comprehensive Cancer Center Ann Arbor Michigan 48109 —
Mayo Clinic in Rochester Rochester Minnesota 55905 —
Siteman Cancer Center at West County Hospital Creve Coeur Missouri 63141 —
Washington University School of Medicine St Louis Missouri 63110 —
Nebraska Medicine-Bellevue Bellevue Nebraska 68123 —
Nebraska Medicine-Village Pointe Omaha Nebraska 68118 —
University of Nebraska Medical Center Omaha Nebraska 68198 —
Roswell Park Cancer Institute Buffalo New York 14263 —
NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center New York New York 10032 —
Memorial Sloan Kettering Cancer Center New York New York 10065 —
Montefiore Medical Center-Einstein Campus The Bronx New York 10461 —
Montefiore Medical Center-Weiler Hospital The Bronx New York 10461 —
Montefiore Medical Center - Moses Campus The Bronx New York 10467 —
Duke University Medical Center Durham North Carolina 27710 —
Cleveland Clinic Foundation Cleveland Ohio 44195 —
Ohio State University Comprehensive Cancer Center Columbus Ohio 43210 —
Fox Chase Cancer Center Philadelphia Pennsylvania 19111 —
University of Pittsburgh Cancer Institute (UPCI) Pittsburgh Pennsylvania 15232 —
Vanderbilt Breast Center at One Hundred Oaks Nashville Tennessee 37204 —
Vanderbilt University/Ingram Cancer Center Nashville Tennessee 37232 —
M D Anderson Cancer Center Houston Texas 77030 —
Huntsman Cancer Institute/University of Utah Salt Lake City Utah 84112 —

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

About this trial record page

What this page shows
Public field values for ClinicalTrials.gov record NCT03148275, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do
No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from
Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh
Last update posted Nov 26, 2024 · Synced Oct 25, 2026

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Open the official record

The complete public registry record, listed eligibility criteria, and available contact information for NCT03148275 live on ClinicalTrials.gov.

View official ClinicalTrials.gov record →