Emricasan, a Caspase Inhibitor, for Treatment of Subjects With Decompensated NASH Cirrhosis
Public ClinicalTrials.gov record NCT03205345. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial of Emricasan, an Oral Caspase Inhibitor, in Subjects With Decompensated Non-Alcoholic Steatohepatitis (NASH) Cirrhosis
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This is a multicenter, double-blind, randomized, placebo-controlled study to evaluate the safety and efficacy of emricasan in improving event-free survival based on a composite clinical endpoint (where all-cause mortality, new decompensation events, and MELD score progression are events) in subjects with decompensated NASH cirrhosis.
Study identification
- NCT ID
- NCT03205345
- Recruitment status
- Not listed
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 210 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jun 28, 2017 (Actual)
- Primary completion
- Aug 2019 (Estimated)
- Completion
- Aug 2019 (Estimated)
- Last update posted
- Mar 19, 2019
2017 – 2019
United States locations
- U.S. sites
- 76
- U.S. states
- 28
- U.S. cities
- 62
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| The Institute for Liver Health | Chandler | Arizona | 85224 | — |
| St. Joseph's Hospital & Medical Center | Phoenix | Arizona | 85013 | — |
| Mayo Clinic Arizona | Phoenix | Arizona | 85054 | — |
| University of Arizona Liver Research Institute | Tucson | Arizona | 85747 | — |
| University of California, San Francisco-Fresno | Fresno | California | 93701 | — |
| Cedars Sinai Medical Center | Los Angeles | California | 90048 | — |
| UCLA Pfleger Liver Institute | Los Angeles | California | 90095 | — |
| California Liver Research Institute | Pasadena | California | 91105 | — |
| Stanford University | Redwood City | California | 94063 | — |
| Inland Empire Liver Foundation | Rialto | California | 92377 | — |
| UC Davis GI/Hepatology Clinical Trials Unit | Sacramento | California | 95817 | — |
| Scripps Clinic - Torrey Pines | San Diego | California | 92037 | — |
| California Pacific Medical Center | San Francisco | California | 94115 | — |
| University of California San Francisco | San Francisco | California | 94143 | — |
| University of Colorado Denver | Aurora | Colorado | 80045 | — |
| Peak Enterology Associates | Colorado Springs | Colorado | 80907 | — |
| West Haven VA Medical Center | West Haven | Connecticut | 06516 | — |
| UF Hepatology Research at CTRB | Gainesville | Florida | 32610 | — |
| Mayo Clinic | Jacksonville | Florida | 32224 | — |
| Florida Research Institute | Lakewood Rch | Florida | 34211 | — |
| Schiff Center for Liver Disease/University of Miami | Miami | Florida | 33136 | — |
| Florida Hospital Transplant Institute | Orlando | Florida | 32804 | — |
| IMIC Inc. | Palmetto Bay | Florida | 33157 | — |
| Tampa General Hospital | Tampa | Florida | 33606 | — |
| Piedmont Transplant Institute | Atlanta | Georgia | 30309 | — |
| Gastrointestinal Specialists of Georgia | Marietta | Georgia | 30060 | — |
| Northwestern University | Chicago | Illinois | 60611 | — |
| Rush University Medical Center | Chicago | Illinois | 60612 | — |
| Aquiant Research | Albany | Indiana | 47150 | — |
| Indiana University | Indianapolis | Indiana | 46202 | — |
| University of Iowa Hospitals and Clinics/ Internal Medicine | Iowa City | Iowa | 52242 | — |
| Delta Research Partners | Bastrop | Louisiana | 71220 | — |
| Ochsner Clinic Foundation | New Orleans | Louisiana | 70121 | — |
| Mercy Medical Center | Baltimore | Maryland | 21202 | — |
| Walter Reed National Military Medical Center (WRNMMC) | Bethesda | Maryland | 20889 | — |
| Digestive Disease Associates, PA | Catonsville | Maryland | 21228 | — |
| Massachusetts General Hospital | Boston | Massachusetts | 02114 | — |
| Beth Israel Deaconess Medical Center | Boston | Massachusetts | 02215 | — |
| Henry Ford Health System | Detroit | Michigan | 48202 | — |
| Mayo Clinic | Rochester | Minnesota | 55901 | — |
| University of Mississippi Medical Center, Division of Digestive Diseases | Jackson | Mississippi | 39216 | — |
| Kansas City Research Institute | Kansas City | Missouri | 64131 | — |
| Rutgers New Jersey Medical School | Newark | New Jersey | 07103 | — |
| Northwell Health Inc., Sandra Atlas Bass Center for Liver Diseases. | Manhasset | New York | 11030 | — |
| NYU Medical Center | New York | New York | 10016 | — |
| Weill Cornell Medical College | New York | New York | 10021 | — |
| Columbia University Medical Center - Center for Liver Disease and Transplantation | New York | New York | 10032 | — |
| University of Rochester Medical Center | Rochester | New York | 14642 | — |
| Carolinas Healthcare System, Center for Liver Disease | Charlotte | North Carolina | 28204 | — |
| Duke University Medical Center | Durham | North Carolina | 27710 | — |
| Diabetes & Endocrinology Consultants, PC | Morehead City | North Carolina | 28557 | — |
| UC Health/ UCPC LLC | Cincinnati | Ohio | 45267 | — |
| Options Health Research, LLC | Tulsa | Oklahoma | 74104 | — |
| Hospital of the University of Pennsylvania | Philadelphia | Pennsylvania | 19104 | — |
| Medical University of South Carolina | Charleston | South Carolina | 29425 | — |
| GHS Gastroenterology and Liver Center | Greenville | South Carolina | 29605 | — |
| ClinSearch, LLC | Chattanooga | Tennessee | 37421 | — |
| Vanderbilt University Medical Center | Nashville | Tennessee | 37232 | — |
| Texas Clinical Research Institute | Arlington | Texas | 76012 | — |
| Methodist Health System Clinical Research Institute | Dallas | Texas | 75203 | — |
| University of Texas Southwestern Medical Center | Dallas | Texas | 75390 | — |
| Baylor Scott & White Research Institute | Fort Worth | Texas | 76104 | — |
| Baylor College of Medicine - Advanced Liver Therapies | Houston | Texas | 77030 | — |
| Liver Associates of Texas, P.A. | Houston | Texas | 77030 | — |
| American Research Corporation at the Texas Liver Institue | San Antonio | Texas | 78215 | — |
| Methodist Specialty & Transplant Hospital | San Antonio | Texas | 78229 | — |
| San Antonio Military Medical Center | San Antonio | Texas | 78234 | — |
| University of Utah | Salt Lake City | Utah | 84132 | — |
| University of Virginia | Charlottesville | Virginia | 22908 | — |
| Emeritas Research Group LLC | Leesburg | Virginia | 20176 | — |
| Banner University Medical Center - Phoenix Transplant Institute | Newport News | Virginia | 23602 | — |
| Bon Secours Liver Institute of Virginia | Richmond | Virginia | 23226 | — |
| Virginia Commonwealth University | Richmond | Virginia | 23298 | — |
| Swedish Organ Transplant and Liver Center | Seattle | Washington | 98104 | — |
| University of Washington Harborview Medical Center | Seattle | Washington | 98104 | — |
| University of Washington | Seattle | Washington | 98195 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT03205345, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Mar 19, 2019 · Synced Oct 21, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT03205345 live on ClinicalTrials.gov.