Sleep Aging and Risk for Alzheimer's 2.0

ClinicalTrials.gov ID: NCT03278119

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Official title

Sleep Aging and Risk for Alzheimer's Resubmission 2.0

Brief summary

Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.

Age-related sleep changes and common sleep disorders like obstructive sleep apnea (OSA) may increase amyloid burden and represent risk factors for cognitive decline in the elderly. We will directly interrogate the brain using a 2-night nocturnal polysomnography (NPSG) and amyloid deposition using C-PiB PET/MR both at baseline and at the 24-month follow-up. This study has the potential to identify the mechanisms by which age-related sleep changes contribute to AD neurodegeneration in cognitively normal elderly, the group that could profit the most from sleep preventive strategies.

Study identification

NCT ID: NCT03278119
Recruitment status: Active, not recruiting
Study type: Observational
Phase: Not listed
Lead sponsor: NYU Langone Health; Other
Enrollment: 158 participants

Conditions and interventions

Conditions

Interventions

PET Scan and nocturnal polysomnography Diagnostic Test

Diagnostic Test

Eligibility (public fields only)

Age range: 55 Years to 75 Years
Sex: All
Healthy volunteers: Accepts healthy volunteers

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: May 1, 2018 (Actual)
Primary completion: Dec 25, 2026 (Estimated)
Completion: Dec 25, 2026 (Estimated)
Last update posted: Mar 30, 2026

2018 – 2026

United States locations

U.S. sites: 1
U.S. states: 1
U.S. cities: 1

Facility	City	State	ZIP	Site status
Healthy Brain Aging and Sleep Center	New York	New York	10016	—

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT03278119, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted Mar 30, 2026 · Synced Nov 15, 2026