A Study of Enfortumab Vedotin Alone or With Other Therapies for Treatment of Urothelial Cancer
Public ClinicalTrials.gov record NCT03288545. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Study of Enfortumab Vedotin (ASG-22CE) as Monotherapy or in Combination With Other Anticancer Therapies for the Treatment of Urothelial Cancer
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This study will test an experimental drug (enfortumab vedotin) alone and with different combinations of anticancer therapies. Pembrolizumab is an immune checkpoint inhibitor (CPI) that is used to treat patients with cancer of the urinary system (urothelial cancer). This type of cancer includes cancer of the bladder, renal pelvis, ureter or urethra. Some parts of the study will look at locally advanced or metastatic urothelial cancer (la/mUC), which means the cancer has spread to nearby tissues or to other areas of the body. Other parts of the study will look at muscle-invasive bladder cancer (MIBC), which is cancer at an earlier stage that has spread into the muscle wall of the bladder. This study will look at the side effects of enfortumab vedotin alone and with other anticancer therapies. A side effect is a response to a drug that is not part of the treatment effect. This study will also test if the cancer shrinks with the different treatment combinations.
Study identification
- NCT ID
- NCT03288545
- Recruitment status
- Terminated
- Study type
- Interventional
- Phase
- Phase 1, Phase 2
- Enrollment
- 348 participants
Conditions and interventions
Conditions
Interventions
- enfortumab vedotin (EV) Drug
- pembrolizumab Drug
- cisplatin Drug
- carboplatin Drug
- gemcitabine Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Oct 11, 2017 (Actual)
- Primary completion
- Feb 20, 2026 (Actual)
- Completion
- Feb 20, 2026 (Actual)
- Last update posted
- Mar 24, 2026
2017 – 2026
United States locations
- U.S. sites
- 83
- U.S. states
- 33
- U.S. cities
- 78
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Alaska Urological Institute | Anchorage | Alaska | 99503 | — |
| Banner MD Anderson Cancer Center | Gilbert | Arizona | 85234 | — |
| Mayo Clinic Arizona | Phoenix | Arizona | 85054 | — |
| Arizona Oncology Associates, PC - HOPE | Tucson | Arizona | 85710 | — |
| Highlands Oncology Group | Fayetteville | Arkansas | 72703 | — |
| Tower Hematology Oncology Medical Group | Beverly Hills | California | 90211 | — |
| UC San Diego / Moores Cancer Center | La Jolla | California | 92093 | — |
| University of California Irvine - Newport | Orange | California | 92868 | — |
| University of California, Davis Comprehensive Cancer Center | Sacramento | California | 95817 | — |
| University of California at San Francisco | San Francisco | California | 94134 | — |
| Saint Joseph Heritage Medical Group | Santa Rosa | California | 95403 | — |
| Stanford Cancer Center / Blood & Marrow Transplant Program | Stanford | California | 94305 | — |
| Kaiser Permanente Southern California | Woodland Hills | California | 91367 | — |
| Rocky Mountain Cancer Centers - Aurora | Aurora | Colorado | 80012 | — |
| University of Colorado Hospital / University of Colorado | Aurora | Colorado | 80045-0510 | — |
| Yale Cancer Center | New Haven | Connecticut | 06520 | — |
| Eastern CT Hematology and Oncology Associates | Norwich | Connecticut | 06360 | — |
| Georgetown University Medical Center | Washington D.C. | District of Columbia | 20007 | — |
| Boca Raton Regional Hospital / Lynn Cancer Institute | Boca Raton | Florida | 33486 | — |
| Holy Cross Hospital - Michael and Dianne Bienes Comprehensive Cancer Center | Fort Lauderdale | Florida | 33308 | — |
| Mayo Clinic Florida | Jacksonville | Florida | 32224 | — |
| University of Miami | Miami | Florida | 33136 | — |
| Piedmont Cancer Institute | Atlanta | Georgia | 30309 | — |
| Winship Cancer Institute / Emory University School of Medicine | Atlanta | Georgia | 30322 | — |
| University of Chicago Medical Center | Chicago | Illinois | 60637-1470 | — |
| Decatur Memorial Hospital - Illinois | Decatur | Illinois | 62526 | — |
| Northwestern Medicine Cancer Center - Kishwaukee / Kishwaukee Cancer Center | DeKalb | Illinois | 60115 | — |
| Northwestern Medicine Cancer Center Delnor | Geneva | Illinois | 60134 | — |
| Cardinal Bernardin Cancer Center / Loyola University Medical Center | Maywood | Illinois | 60153 | — |
| Northwestern Medicine Cancer Center - Warrenville / Central DuPage Hospital - Cancer Care | Warrenville | Illinois | 60555 | — |
| University of Kansas Cancer Center | Westwood | Kansas | 66205 | — |
| Tulane University Hospital and Clinic | New Orleans | Louisiana | 70112 | — |
| Ochsner Clinic Foundation | New Orleans | Louisiana | 70121 | — |
| Maryland Oncology Hematology, P.A. | Silver Spring | Maryland | 20904 | — |
| Southcoast Centers for Cancer Care - Fairhaven Site | Fairhaven | Massachusetts | 02719 | — |
| University of Michigan Comprehensive Cancer Center | Ann Arbor | Michigan | 48109 | — |
| Henry Ford Health System | Detroit | Michigan | 48202 | — |
| McLaren Greater Lansing Hospital | Lansing | Michigan | 48910 | — |
| University of Minnesota | Minneapolis | Minnesota | 55455 | — |
| University of Mississippi Medical Center | Jackson | Mississippi | 39213 | — |
| Washington University School of Medicine - Siteman Cancer Center | St Louis | Missouri | 63110 | — |
| Nebraska Hematology Oncology P.C. | Lincoln | Nebraska | 68506 | — |
| OptumCare Cancer Center | Las Vegas | Nevada | 89102 | — |
| Memorial Sloan Kettering Cancer Center - Basking Ridge | Basking Ridge | New Jersey | 07920 | — |
| Hackensack University Medical Center | Hackensack | New Jersey | 07601 | — |
| Memorial Sloan Kettering Cancer Center - Monmouth | Middletown | New Jersey | 07748 | — |
| Memorial Sloan Kettering Cancer Center - Bergen | Montvale | New Jersey | 07645 | — |
| University of New Mexico Cancer Center | Albuquerque | New Mexico | 87106 | — |
| New York Oncology Hematology, P.C. | Albany | New York | 12206 | — |
| Roswell Park Cancer Institute | Buffalo | New York | 14263 | — |
| Memorial Sloan Kettering Cancer Center - Commack | Commack | New York | 11725 | — |
| Memorial Sloan Kettering Cancer Center - Westchester | Harrison | New York | 10604 | — |
| Northwell Cancer Center / Monter Cancer Center | Lake Success | New York | 11042 | — |
| NYU Winthrop Hospital | Mineola | New York | 11501 | — |
| New York University (NYU) Cancer Institute | New York | New York | 10016 | — |
| Weill Cornell Medical College | New York | New York | 10065 | — |
| Memorial Sloan Kettering Cancer Center | New York | New York | 10087-9049 | — |
| University of Rochester Medical Center | Rochester | New York | 14642 | — |
| Memorial Sloan Kettering Cancer Center - Nassau | Uniondale | New York | 11553 | — |
| UNC Lineberger Comprehensive Cancer Center / University of North Carolina | Chapel Hill | North Carolina | 27599 | — |
| Levine Cancer Institute | Charlotte | North Carolina | 28204 | — |
| Duke University Medical Center | Durham | North Carolina | 27710 | — |
| Vidant Medical Center | Greenville | North Carolina | 27834 | — |
| Gabrail Cancer Center Research, LLC | Canton | Ohio | 44718 | — |
| Case Western Reserve University / University Hospitals Case Medical Center | Cleveland | Ohio | 44106 | — |
| Toledo Clinic Cancer Center | Toledo | Ohio | 43623 | — |
| CMOH Broomall | Broomall | Pennsylvania | 19008 | — |
| Penn State Milton S. Hershey Medical Center | Hershey | Pennsylvania | 17033 | — |
| Fox Chase Cancer Center | Philadelphia | Pennsylvania | 19111 | — |
| Allegheny General Hospital | Pittsburgh | Pennsylvania | 15212 | — |
| Medical University of South Carolina/Hollings Cancer Center | Charleston | South Carolina | 29425 | — |
| Saint Francis Hospital Cancer Center | Greenville | South Carolina | 29607 | — |
| Carolina Urologic Research Center | Myrtle Beach | South Carolina | 29572 | — |
| Sarah Cannon Research Institute | Chattanooga | Tennessee | 37404 | — |
| Tennessee Oncology / Sarah Cannon Research Institute | Nashville | Tennessee | 37203 | — |
| Texas Oncology - Fort Worth Cancer Center | Fort Worth | Texas | 76104 | — |
| University of Texas Health Science Center at San Antonio | San Antonio | Texas | 78229 | — |
| Texas Oncology - Tyler | Tyler | Texas | 75702 | — |
| Utah Cancer Specialists | Salt Lake City | Utah | 84106 | — |
| University of Virginia | Charlottesville | Virginia | 22903 | — |
| Virginia Oncology Associates - Norfolk | Norfolk | Virginia | 23502 | — |
| Medical Oncology Associates | Spokane | Washington | 99208 | — |
| Medical College of Wisconsin (Milwaukee) | Milwaukee | Wisconsin | 53226 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 23 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT03288545, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Mar 24, 2026 · Synced Oct 24, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT03288545 live on ClinicalTrials.gov.