Trametinib and Trifluridine and Tipiracil Hydrochloride in Treating Patients With Colon or Rectal Cancer That is Advanced, Metastatic, or Cannot Be Removed by Surgery

ClinicalTrials.gov ID: NCT03317119

Public ClinicalTrials.gov record NCT03317119. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced May 21, 2026, 12:56 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Phase I Clinical Trial of Trametinib in Combination With TAS-102 in Patients With Chemotherapy-Resistant RAS-Mutated (PIK3CA/PTEN-Wild-Type) Metastatic Colorectal Cancer

Study identification

NCT ID: NCT03317119
Recruitment status: Completed
Study type: Interventional
Phase: Phase 1
Lead sponsor: City of Hope Medical Center; Other
Enrollment: 26 participants

Conditions and interventions

Conditions

Interventions

Laboratory Biomarker Analysis Other
Trametinib Drug
Trifluridine and Tipiracil Hydrochloride Drug

Other · Drug

Eligibility (public fields only)

Age range: 18 Years and older
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Apr 10, 2018
Primary completion: Jul 13, 2023
Completion: Jul 13, 2023
Last update posted: Apr 7, 2024

2018 – 2023

United States locations

U.S. sites: 8
U.S. states: 1
U.S. cities: 8

Facility	City	State	ZIP	Site status
City of Hope Corona	Corona	California	92879	—
City of Hope Medical Center	Duarte	California	91010	—
City of Hope Antelope Valley	Lancaster	California	93534	—
City of Hope Mission Hills	Mission Hills	California	91345	—
City of Hope Rancho Cucamonga	Rancho Cucamonga	California	91730	—
City of Hope - Santa Clarita	Santa Clarita	California	91355	—
City of Hope South Pasadena	South Pasadena	California	91030	—
City of Hope West Covina	West Covina	California	91790	—

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT03317119, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted Apr 7, 2024 · Synced May 21, 2026

Open the official record

The complete protocol, eligibility criteria, and contact information for NCT03317119 live on ClinicalTrials.gov.

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