Tesetaxel Plus Reduced Dose of Capecitabine vs. Capecitabine in HER2 Negative, HR Positive, LA/MBC
Public ClinicalTrials.gov record NCT03326674. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Multinational, Multicenter, Randomized, Phase 3 Study of Tesetaxel Plus a Reduced Dose of Capecitabine Versus Capecitabine Alone in Patients With HER2 Negative, HR Positive, Locally Advanced or Metastatic Breast Cancer Previously Treated With a Taxane
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
CONTESSA is a multinational, multicenter, randomized, Phase 3 study of tesetaxel in patients with HER2 negative, HR positive LA/MBC previously treated with a taxane in the neoadjuvant or adjuvant setting. The primary objective of the study is to compare the efficacy of tesetaxel plus a reduced dose of capecitabine versus the approved dose of capecitabine alone based on progression-free survival (PFS) as assessed by the Independent Radiologic Review Committee (IRC). 685 patients were enrolled.
Study identification
- NCT ID
- NCT03326674
- Recruitment status
- Terminated
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 685 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Dec 21, 2017 (Actual)
- Primary completion
- Aug 24, 2020 (Actual)
- Completion
- Jun 28, 2021 (Actual)
- Last update posted
- Jul 30, 2021
2017 – 2021
United States locations
- U.S. sites
- 90
- U.S. states
- 30
- U.S. cities
- 84
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Ironwood Cancer and Research Centers | Chandler | Arizona | 85224 | — |
| Cancer Treatment Centers of America - Western Regional Medical Center | Goodyear | Arizona | 85338 | — |
| Arizona Oncology Associates, P.C. - HOPE | Tucson | Arizona | 85704 | — |
| Genesis Cancer Center | Hot Springs | Arkansas | 71913 | — |
| Carti Cancer Center | Little Rock | Arkansas | 72205 | — |
| Pacific Cancer Medical Center | Anaheim | California | 92801-1824 | — |
| CBCC Global Research, Inc. | Bakersfield | California | 93309 | — |
| Compassionate Care Research Group | Fountain Valley | California | 92708 | — |
| California Cancer Associates for Research and Excellence | Fresno | California | 93720 | — |
| St. Joseph Heritage Healthcare | Fullerton | California | 92835 | — |
| UCLA Medical Center | Los Angeles | California | 90024 | — |
| Cancer Care - Torrance Memorial Physician Network | Redondo Beach | California | 90277 | — |
| Sharp Memorial Hospital | San Diego | California | 92123 | — |
| University of California San Francisco - Helen Diller Family Comprehensive Cancer Center | San Francisco | California | 94115 | — |
| San Luis Obispo Oncology & Hematology Health Center | San Luis Obispo | California | 93401 | — |
| California Cancer Associates for Research and Excellence | San Marcos | California | 92069 | — |
| Cancer Research Collaboration and Breast Link | Santa Ana | California | 92705 | — |
| Stanford Cancer Center / Cancer Clinical Trials | Stanford | California | 94304 | — |
| Innovative Clinical Research Institute | Whittier | California | 90603 | — |
| Rocky Mountain Cancer Center | Lakewood | Colorado | 80228 | — |
| Western Connecticut Health Network | Danbury | Connecticut | 06810 | — |
| Hartford Healthcare | Hartford | Connecticut | 06106 | — |
| Sarah Cannon Research Institute - Florida Cancer Specialists | Fort Myers | Florida | 33901 | — |
| Memorial Healthcare System | Hollywood | Florida | 33021 | — |
| Cancer Specialists of North Florida | Jacksonville | Florida | 32256 | — |
| Miami Cancer Institute | Miami | Florida | 33176 | — |
| Florida Cancer Affiliates - Ocala | Ocala | Florida | 34471 | — |
| Orlando Health | Orlando | Florida | 32806 | — |
| University of Miami Sylvester Comprehensive Cancer Center / Sylvester at Plantation | Plantation | Florida | 33324 | — |
| Florida Cancer Specialists and Research Institute | St. Petersburg | Florida | 33705 | — |
| Florida Cancer Specialists and Research Institute - Panhandle Region | Tallahassee | Florida | 32308 | — |
| Florida Cancer Specialists and Research Institute | West Palm Beach | Florida | 33401 | — |
| University Cancer and Blood Center | Athens | Georgia | 30607 | — |
| Cancer Treatment Centers of America | Newnan | Georgia | 30265 | — |
| University of Chicago Medical Center - Duchossois Center for Advanced Medicine (DCAM) | Chicago | Illinois | 60637 | — |
| Orchard Healthcare Research | Skokie | Illinois | 60077 | — |
| American Health Network | Indianapolis | Indiana | 46260 | — |
| Baptist Health Lexington | Lexington | Kentucky | 40503 | — |
| SMHC Cancer Care and Blood Disorders | Biddeford | Maine | 04005 | — |
| University of Maryland - Greenebaum Comprehensive Cancer Center | Baltimore | Maryland | 21201 | — |
| GBMC Cancer Center | Baltimore | Maryland | 21204 | — |
| Chevy Chase Health Care Center/ RCCA | Chevy Chase | Maryland | 20815 | — |
| James M. Stockman Cancer Institute | Frederick | Maryland | 21702 | — |
| Maryland Oncology Hematology, P.A. | Rockville | Maryland | 20850 | — |
| Dana-Farber Cancer Institute | Boston | Massachusetts | 02215 | — |
| Henry Ford Hospital | Detroit | Michigan | 48202 | — |
| Cancer and Hematology Centers of Western Michigan | Grand Rapids | Michigan | 49503 | — |
| Virginia Piper Cancer Institute, Allina Health | Minneapolis | Minnesota | 55407 | — |
| Forrest General Cancer Center/Hattiesburg Clinic | Hattiesburg | Mississippi | 39401 | — |
| Jackson Oncology Associates | Jackson | Mississippi | 39202 | — |
| Mercy Cancer Center | Joplin | Missouri | 64804 | — |
| HCA Midwest Health | Kansas City | Missouri | 64131 | — |
| Washington University School of Medicine | St Louis | Missouri | 63110 | — |
| Mercy Hospital St. Louis, David C. Pratt Cancer Center | St Louis | Missouri | 63141 | — |
| St. Vincent Frontier Cancer Center | Billings | Montana | 59102 | — |
| Oncology Hematology West, P.C. dba Nebraska Cancer Specialists | Papillion | Nebraska | 68046 | — |
| New Jersey Hematology Oncology Associates | Brick | New Jersey | 08724 | — |
| Regional Cancer Care Associates | East Brunswick | New Jersey | 08816 | — |
| The Valley Hospital | Ridgewood | New Jersey | 07451 | — |
| Regional Cancer Care Associates, LLC-Sparta | Sparta | New Jersey | 07871 | — |
| New Mexico Cancer Care Alliance - Southwest Gynecology Oncology | Albuquerque | New Mexico | 87131 | — |
| New York Oncology Hematology, P.C. | Albany | New York | 12206 | — |
| New York Cancer and Blood Specialists | East Setauket | New York | 11733 | — |
| Hematology Oncology Associates of Central New York, P.C. | East Syracuse | New York | 13057 | — |
| Broome Oncology, LLC | Johnson City | New York | 13790 | — |
| Memorial Sloan Kettering Cancer Center | New York | New York | 10065 | — |
| University of North Carolina Lineberger Cancer Center | Chapel Hill | North Carolina | 27599 | — |
| Ohio State University Comprehensive Cancer Center, Stephanie Spielman Comprehensive Breast Center | Columbus | Ohio | 43212 | — |
| Mercy Clinic Oncology and Hematology | Oklahoma City | Oklahoma | 73120 | — |
| Oklahoma Cancer Specialists and Research Institute, LLC | Tulsa | Oklahoma | 74146 | — |
| Lehigh Valley Health Network | Allentown | Pennsylvania | 18103 | — |
| Cancer Treatment Centers of America - Philadelphia | Philadelphia | Pennsylvania | 19124 | — |
| Magee-Women's Hospital of UPMC | Pittsburgh | Pennsylvania | 15601 | — |
| West Cancer Center | Germantown | Tennessee | 38138 | — |
| Sarah Cannon Research Institute at Tennessee Oncology | Nashville | Tennessee | 37203 | — |
| Texas Oncology - Bedford | Bedford | Texas | 76022 | — |
| Texas Oncology - Medical City Dallas | Dallas | Texas | 75230 | — |
| Texas Oncology - Dallas Presbyterian Hospital | Dallas | Texas | 75231 | — |
| Texas Oncology - Baylor Charles A. Sammons Cancer Center | Dallas | Texas | 75246 | — |
| Texas Oncology - Memorial City | Houston | Texas | 77024 | — |
| Westside Surgical Hospital and Breast Center | Houston | Texas | 77024 | — |
| Oncology Consultants | Houston | Texas | 77030 | — |
| Hope Cancer Center of East Texas | Tyler | Texas | 75701 | — |
| Bon Secours St. Francis | Midlothian | Virginia | 23114 | — |
| Virginia Oncology Associates | Norfolk | Virginia | 23502 | — |
| Virginia Cancer Institute | Richmond | Virginia | 23226 | — |
| Overlake Medical Center | Bellevue | Washington | 98004 | — |
| Kadlec Regional Medical Center | Kennewick | Washington | 99336 | — |
| Swedish Cancer Center | Seattle | Washington | 98104 | — |
| Northwest Medical Specialties | Tacoma | Washington | 98405 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 117 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT03326674, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jul 30, 2021 · Synced Oct 30, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT03326674 live on ClinicalTrials.gov.