Study Evaluating Safety and Efficacy of JCAR017 in Subjects With Relapsed or Refractory Chronic Lymphocytic Leukemia (CLL) or Small Lymphocytic Lymphoma (SLL)
Public ClinicalTrials.gov record NCT03331198. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.
Official title
An Open-Label, Phase 1/2 Study of JCAR017 in Subjects With Relapsed or Refractory Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma (017004)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This is a Phase 1/2, open-label, multicenter study to determine the efficacy and safety of JCAR017 in adult subjects with relapsed or refractory CLL or SLL. The study will include a Phase 1 part to determine the recommended dose of JCAR017 monotherapy in subjects with relapsed or refractory CLL or SLL, followed by a Phase 2 part to further assess the efficacy and safety of JCAR017 monotherapy treatment at the recommended dose. A separate Phase 1 cohort will assess the combination of JCAR017 and concurrent ibrutinib. Another separate Phase 1 cohort will assess the combination of JCAR017 and concurrent venetoclax. In all subjects, the safety, efficacy, and pharmacokinetics (PK) of JCAR017 will be evaluated.
Study identification
- NCT ID
- NCT03331198
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Phase 1, Phase 2
- Enrollment
- 320 participants
Conditions and interventions
Interventions
- JCAR017 (lisocabtagene maraleucel) Biological
- JCAR017 (lisocabtagene maraleucel) + ibrutinib Biological
- JCAR017 (lisocabtagene maraleucel) + venetoclax Biological
Biological
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Nov 27, 2017 (Actual)
- Primary completion
- Nov 26, 2027 (Estimated)
- Completion
- Nov 26, 2027 (Estimated)
- Last update posted
- Jul 6, 2026
2017 – 2027
United States locations
- U.S. sites
- 83
- U.S. states
- 29
- U.S. cities
- 44
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Local Institution - 0006 | Birmingham | Alabama | 35294 | — |
| University of Alabama at Birmingham | Birmingham | Alabama | 35294 | — |
| Banner MD Anderson Cancer Center | Gilbert | Arizona | 85234 | — |
| Local Institution - 0043 | Gilbert | Arizona | 85234 | — |
| City of Hope | Duarte | California | 91010 | — |
| Local Institution - 0007 | Duarte | California | 91010 | — |
| Local Institution - 0025 | La Jolla | California | 92093 | — |
| UC San Diego Moores Cancer Center | La Jolla | California | 92093 | — |
| Local Institution - 0059 | Los Angeles | California | 90095 | — |
| University of California, Los Angeles | Los Angeles | California | 90095 | — |
| Local Institution - 0010 | San Francisco | California | 94143 | — |
| University of California, San Francisco | San Francisco | California | 94143 | — |
| Local Institution - 0111 | Denver | Colorado | 80218 | — |
| Georgetown University Medical Center | Washington D.C. | District of Columbia | 20007 | — |
| Local Institution - 0085 | Washington D.C. | District of Columbia | 20007 | — |
| Local Institution - 0080 | Jacksonville | Florida | 32224 | — |
| Mayo Clinic | Jacksonville | Florida | 32224 | — |
| Local Institution - 0104 | Atlanta | Georgia | 30322 | — |
| Local Institution - 0019 | Atlanta | Georgia | 30342 | — |
| The Blood and Marrow Transplant Group of Georgia (BMTGA) | Atlanta | Georgia | 30342 | — |
| Local Institution - 0003 | Chicago | Illinois | 60611 | — |
| Northwestern University | Chicago | Illinois | 60611 | — |
| Local Institution - 0016 | Chicago | Illinois | 60637 | — |
| University of Chicago Medical Center | Chicago | Illinois | 60637 | — |
| Local Institution - 0105 | Indianapolis | Indiana | 46237 | — |
| Local Institution - 0107 | Wichita | Kansas | 67124 | — |
| Local Institution - 0064 | Louisville | Kentucky | 40202 | — |
| Local Institution - 0027 | New Orleans | Louisiana | 70112 | — |
| Local Institution - 0005 | Boston | Massachusetts | 02114 | — |
| Massachusetts General Hospital | Boston | Massachusetts | 02114 | — |
| Beth Israel Deaconess Medical Center | Boston | Massachusetts | 02215 | — |
| Local Institution - 0015 | Boston | Massachusetts | 02215 | — |
| University of Michigan Comprehensive Cancer Center | Ann Arbor | Michigan | 48109-5362 | — |
| Local Institution - 0084 | Ann Arbor | Michigan | 48109 | — |
| Barbara Ann Karmanos Cancer Institute | Detroit | Michigan | 48201 | — |
| Local Institution - 0062 | Detroit | Michigan | 48201 | — |
| Local Institution - 0109 | Detroit | Michigan | 48202 | — |
| Local Institution - 0054 | Rochester | Minnesota | 55905 | — |
| Mayo Clinic | Rochester | Minnesota | 55905 | — |
| Local Institution - 0008 | Omaha | Nebraska | 68198 | — |
| University of Nebraska Medical Center | Omaha | Nebraska | 68198 | — |
| Local Institution - 0001 | Basking Ridge | New Jersey | 07920 | — |
| Local Institution - 0114 | Edison | New Jersey | 08820 | — |
| Local Institution - 0038 | Hackensack | New Jersey | 07601-2191 | — |
| Hackensack University Medical Center | Hackensack | New Jersey | 07601 | — |
| Local Institution - 0106 | Morristown | New Jersey | 07960 | — |
| Local Institution - 0077 | New Brunswick | New Jersey | 08903 | — |
| Rutgers Cancer Institute of New Jersey | New Brunswick | New Jersey | 08903 | — |
| Local Institution - 0035 | New York | New York | 10021 | — |
| Local Institution - 0026 | New York | New York | 10032 | — |
| Weill Cornell Medical College | New York | New York | 10065 | — |
| Local Institution - 0089 | Stony Brook | New York | 11794-8160 | — |
| Local Institution - 0120 | Charlotte | North Carolina | 28204 | — |
| Local Institution - 0030 | Durham | North Carolina | 27705 | — |
| Duke University Medical Center | Durham | North Carolina | 27710 | — |
| Local Institution - 0118 | Winston-Salem | North Carolina | 27157 | — |
| University Hospitals Seidman Cancer Center (Case Western) | Cleveland | Ohio | 44106-5061 | — |
| Local Institution - 0078 | Cleveland | Ohio | 44106 | — |
| Local Institution - 0031 | Columbus | Ohio | 43210 | — |
| Local Institution - 0082 | Oklahoma City | Oklahoma | 73104 | — |
| University of Oklahoma Health Sciences Center (Stephenson Cancer Center) | Oklahoma City | Oklahoma | 73104 | — |
| Local Institution - 0098 | Eugene | Oregon | 97401 | — |
| Local Institution - 0088 | Philadelphia | Pennsylvania | 19104 | — |
| University of Pennsylvania Perelman Center for Advanced Medicine | Philadelphia | Pennsylvania | 19104 | — |
| Local Institution - 0032 | Philadelphia | Pennsylvania | 19107 | — |
| Thomas Jefferson University | Philadelphia | Pennsylvania | 19107 | — |
| Local Institution - 0029 | Pittsburgh | Pennsylvania | 15232 | — |
| UPMC Hillman Cancer Center | Pittsburgh | Pennsylvania | 15232 | — |
| Local Institution - 0117 | Chattanooga | Tennessee | 37403 | — |
| Local Institution - 0119 | Nashville | Tennessee | 37203 | — |
| Baylor University Medical Center | Dallas | Texas | 75246 | — |
| Local Institution - 0083 | Dallas | Texas | 75390 | — |
| University of Texas Southwestern Medical Center | Dallas | Texas | 75390 | — |
| Local Institution - 0079 | Dallas | Texas | 75426 | — |
| Local Institution - 0002 | Houston | Texas | 77030 | — |
| The University of Texas MD Anderson Cancer Center | Houston | Texas | 77030 | — |
| Huntsman Cancer Institute | Salt Lake City | Utah | 84112 | — |
| Local Institution - 0028 | Salt Lake City | Utah | 84112 | — |
| Local Institution - 0087 | Richmond | Virginia | 23298 | — |
| Fred Hutchinson Cancer Research Center | Seattle | Washington | 98109 | — |
| Local Institution - 0018 | Seattle | Washington | 98109 | — |
| Local Institution - 0055 | Milwaukee | Wisconsin | 53226 | — |
| Medical College of Wisconsin | Milwaukee | Wisconsin | 53226 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 1 non-U.S. site.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT03331198, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jul 6, 2026 · Synced Nov 4, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT03331198 live on ClinicalTrials.gov.