Study Evaluating Safety and Efficacy of JCAR017 in Subjects With Relapsed or Refractory Chronic Lymphocytic Leukemia (CLL) or Small Lymphocytic Lymphoma (SLL)

ClinicalTrials.gov ID: NCT03331198

Public ClinicalTrials.gov record NCT03331198. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced May 10, 2026, 4:06 PM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

An Open-Label, Phase 1/2 Study of JCAR017 in Subjects With Relapsed or Refractory Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma (017004)

Study identification

NCT ID: NCT03331198
Recruitment status: Recruiting
Study type: Interventional
Phase: Phase 1, Phase 2
Lead sponsor: Juno Therapeutics, a Subsidiary of Celgene; Industry
Enrollment: 320 participants

Conditions and interventions

Conditions

Interventions

JCAR017 (lisocabtagene maraleucel) Biological
JCAR017 (lisocabtagene maraleucel) + ibrutinib Biological
JCAR017 (lisocabtagene maraleucel) + venetoclax Biological

Biological

Eligibility (public fields only)

Age range: 18 Years and older
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Nov 26, 2017
Primary completion: Nov 25, 2027
Completion: Nov 25, 2027
Last update posted: Mar 3, 2026

2017 – 2027

United States locations

U.S. sites: 82
U.S. states: 30
U.S. cities: 43

Facility	City	State	ZIP	Site status
University of Alabama at Birmingham	Birmingham	Alabama	35294	Recruiting
University of Alabama Birmingham	Birmingham	Alabama	35294	Recruiting
Banner MD Anderson Cancer Center	Gilbert	Arizona	85234	Recruiting
City of Hope	Duarte	California	91010	Recruiting
City Of Hope	Duarte	California	91010	Recruiting
UC San Diego Moores Cancer Center	La Jolla	California	92093	Recruiting
University Of California San Diego Moores Cancer Center	La Jolla	California	92093	Recruiting
Local Institution - 0059	Los Angeles	California	90095	Active, not recruiting
University of California, Los Angeles	Los Angeles	California	90095	Recruiting
Local Institution - 0010	San Francisco	California	94143	Active, not recruiting
University of California, San Francisco	San Francisco	California	94143	Recruiting
Colorado Blood Cancer Institute	Denver	Colorado	80218	Recruiting
Local Institution - 0110	Newark	Delaware	19713	Withdrawn
Georgetown University Medical Center	Washington D.C.	District of Columbia	20007	Recruiting
Local Institution - 0085	Washington D.C.	District of Columbia	20007	Completed
Mayo Clinic - Jacksonville	Jacksonville	Florida	32224	Recruiting
Mayo Clinic	Jacksonville	Florida	32224	Recruiting
Local Institution - 0104	Atlanta	Georgia	30322	Not yet recruiting
Local Institution - 0019	Atlanta	Georgia	30342	Active, not recruiting
The Blood and Marrow Transplant Group of Georgia (BMTGA)	Atlanta	Georgia	30342	Recruiting
Northwestern Memorial Hospital	Chicago	Illinois	60611	Recruiting
Northwestern University	Chicago	Illinois	60611	Recruiting
University of Chicago Medical Center	Chicago	Illinois	60637	Recruiting
University Of Chicago Medical Center	Chicago	Illinois	60637	Recruiting
Franciscan St. Francis Health - Indiana Blood and Marrow Transplantation (IBMT)	Indianapolis	Indiana	46237	Recruiting
Local Institution - 0107	Wichita	Kansas	67124	Not yet recruiting
Norton Healthcare - Norton Cancer Institute	Louisville	Kentucky	40202	Recruiting
Local Institution - 0027	New Orleans	Louisiana	70112	Completed
Local Institution - 0005	Boston	Massachusetts	02114	Active, not recruiting
Massachusetts General Hospital	Boston	Massachusetts	02114	Recruiting
Beth Israel Deaconess Medical Center	Boston	Massachusetts	02215	Recruiting
Local Institution - 0015	Boston	Massachusetts	02215	Active, not recruiting
University of Michigan Comprehensive Cancer Center	Ann Arbor	Michigan	48109-5362	Recruiting
University Of Michigan Comprehensive Cancer Center	Ann Arbor	Michigan	48109	Recruiting
Barbara Ann Karmanos Cancer Institute	Detroit	Michigan	48201	Recruiting
Local Institution - 0062	Detroit	Michigan	48201	Active, not recruiting
Local Institution - 0109	Detroit	Michigan	48202	Not yet recruiting
Mayo Clinic	Rochester	Minnesota	55905	Recruiting
University of Nebraska Medical Center	Omaha	Nebraska	68198	Recruiting
University Of Nebraska Medical Center	Omaha	Nebraska	68198	Recruiting
Memorial Sloan-Kettering Cancer Center (MSKCC) - Basking Ridge	Basking Ridge	New Jersey	07920	Recruiting
Astera Cancer Care	Edison	New Jersey	08820	Recruiting
John Theurer Cancer Center	Hackensack	New Jersey	07601-2191	Recruiting
Hackensack University Medical Center	Hackensack	New Jersey	07601	Recruiting
Atlantic Health System / Morristown Medical Center	Morristown	New Jersey	07960	Recruiting
Local Institution - 0077	New Brunswick	New Jersey	08903	Completed
Rutgers Cancer Institute of New Jersey	New Brunswick	New Jersey	08903	Recruiting
Local Institution - 0035	New York	New York	10021	Active, not recruiting
Columbia University Medical Center	New York	New York	10032	Withdrawn
Local Institution - 0026	New York	New York	10032	Completed
Weill Cornell Medical College	New York	New York	10065	Recruiting
Stony Brook University	Stony Brook	New York	11794-8160	Recruiting
Duke University Medical Center	Durham	North Carolina	27705	Recruiting
Duke University Medical Center	Durham	North Carolina	27710	Recruiting
University Hospitals Seidman Cancer Center (Case Western)	Cleveland	Ohio	44106-5061	Recruiting
University Hospitals Cleveland Medical Center	Cleveland	Ohio	44106	Recruiting
The Ohio State University Comprehensive Cancer Center	Columbus	Ohio	43210	Recruiting
University of Oklahoma Health Sciences Center (Stephenson Cancer Center)	Oklahoma City	Oklahoma	73104	Recruiting
University of Oklahoma Peggy and Charles Stephenson Cancer Center	Oklahoma City	Oklahoma	73104	Recruiting
Local Institution - 0098	Eugene	Oregon	97401	Completed
University of Pennsylvania - Perelman Center for Advanced Medicine	Philadelphia	Pennsylvania	19104	Recruiting
University of Pennsylvania Perelman Center for Advanced Medicine	Philadelphia	Pennsylvania	19104	Recruiting
Thomas Jefferson University - Clinical Research Institute	Philadelphia	Pennsylvania	19107	Recruiting
Thomas Jefferson University	Philadelphia	Pennsylvania	19107	Recruiting
Local Institution - 0029	Pittsburgh	Pennsylvania	15232	Active, not recruiting
UPMC Hillman Cancer Center	Pittsburgh	Pennsylvania	15232	Recruiting
Sarah Cannon Research Institute - Tennessee Oncology	Nashville	Tennessee	37203	Recruiting
Baylor University Medical Center	Dallas	Texas	75246	Recruiting
Local Institution - 0083	Dallas	Texas	75390	Completed
University of Texas Southwestern Medical Center	Dallas	Texas	75390	Recruiting
Local Institution - 0079	Dallas	Texas	75426	Completed
The University of Texas - MD Anderson Cancer Center	Houston	Texas	77030	Recruiting
The University of Texas MD Anderson Cancer Center	Houston	Texas	77030	Recruiting
Huntsman Cancer Institute	Salt Lake City	Utah	84112	Recruiting
Local Institution - 0028	Salt Lake City	Utah	84112	Active, not recruiting
Local Institution - 0113	Charlottesville	Virginia	22903	Withdrawn
Local Institution - 0087	Richmond	Virginia	23298	Completed
Virginia Commonwealth University	Richmond	Virginia	23298	Withdrawn
Fred Hutchinson Cancer Research Center	Seattle	Washington	98109	Recruiting
Seattle Cancer Center Alliance	Seattle	Washington	98109	Recruiting
Froedtert Hospital BMT Medical College of Wisconsin	Milwaukee	Wisconsin	53226	Recruiting
Medical College of Wisconsin	Milwaukee	Wisconsin	53226	Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 2 non-U.S. sites.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT03331198, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted Mar 3, 2026 · Synced May 10, 2026

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The complete protocol, eligibility criteria, and contact information for NCT03331198 live on ClinicalTrials.gov.

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