A Study of Ipatasertib in Combination With Paclitaxel as a Treatment for Participants With PIK3CA/AKT1/PTEN-Altered, Locally Advanced or Metastatic, Triple-Negative Breast Cancer or Hormone Receptor-Positive, HER2-Negative Breast Cancer
Public ClinicalTrials.gov record NCT03337724. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Double-Blind, Placebo-Controlled, Randomized Phase III Study of Ipatasertib in Combination With Paclitaxel as a Treatment for Patients With PIK3CA/AKT1/PTEN-Altered, Locally Advanced or Metastatic, Triple-Negative Breast Cancer or Hormone Receptor-Positive, HER2-Negative Breast Cancer
Study identification
- NCT ID
- NCT03337724
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Lead sponsor
- Hoffmann-La Roche
- Industry
- Enrollment
- 579 participants
Conditions and interventions
Conditions
Interventions
- Ipatasertib Drug
- Paclitaxel Drug
- Placebo Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jan 5, 2018
- Primary completion
- Jan 3, 2023
- Completion
- Jan 3, 2023
- Last update posted
- Mar 11, 2024
2018 – 2023
United States locations
- U.S. sites
- 28
- U.S. states
- 6
- U.S. cities
- 23
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| UCSD Moores Cancer Center | La Jolla | California | 92093 | — |
| USC Norris Cancer Center | Los Angeles | California | 90033 | — |
| USC Norris Cancer Center; USC Oncology Hematology Newport Beach | Newport Beach | California | 92663 | — |
| Kaiser Permanente - Oakland | Oakland | California | 94611 | — |
| Kaiser Permanente - Roseville | Roseville | California | 95661 | — |
| UC Davis; Comprehensive Cancer Center | Sacramento | California | 95817 | — |
| Kaiser Permanente Sacramento Medical Center | Sacramento | California | 95825 | — |
| Kaiser Permanente - San Francisco (2238 Geary) | San Francisco | California | 94115 | — |
| UCSF Comprehensive Cancer Ctr | San Francisco | California | 94158 | — |
| K. Permanente - San Jose | San Jose | California | 95119 | — |
| Kaiser Permanente - San Leandro | San Leandro | California | 94577 | — |
| K. Permanente - Santa Clara | Santa Clara | California | 95051 | — |
| Kaiser Permanente - South San Francisco | South San Francisco | California | 94080 | — |
| Kaiser Permanente - Vallejo | Vallejo | California | 94589 | — |
| K. Permanente - Walnut Creek | Walnut Creek | California | 94596 | — |
| Memorial Regional Hospital | Hollywood | Florida | 33021 | — |
| Mount Sinai Comprehensive Cancer Center | Miami Beach | Florida | 33140 | — |
| UF Health Cancer Center at Orlando Health | Orlando | Florida | 32824 | — |
| Memorial Hospital West | Pembroke Pines | Florida | 33028 | — |
| University of Maryland | Baltimore | Maryland | 21201 | — |
| Mercy Medical Center | Baltimore | Maryland | 21202 | — |
| Johns Hopkins Sidney Kimmel Comprehensive Cancer Center | Baltimore | Maryland | 21287 | — |
| Memorial Sloan Kettering Cancer Center at Westchester | Harrison | New York | 10604 | — |
| Memorial Sloan Kettering | New York | New York | 10065 | — |
| West Clinic | Germantown | Tennessee | 38138 | — |
| Texas Oncology, P.A. | Dallas | Texas | 75246 | — |
| UT Southwestern Medical Center; Simmons Comprehensive Cancer Center, Simmons Pharmacy | Dallas | Texas | 75390 | — |
| Oncology Consultants PA | Houston | Texas | 77030 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 148 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT03337724, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Mar 11, 2024 · Synced Apr 29, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT03337724 live on ClinicalTrials.gov.