A Dose Ranging Study of OPT-302 With Ranibizumab in Neovascular (Wet) AMD
Public ClinicalTrials.gov record NCT03345082. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Dose-Ranging Study of Intravitreal OPT-302 in Combination With Ranibizumab, Compared With Ranibizumab Alone, in Participants With Neovascular Age-Related Macular Degeneration (Wet AMD)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
A multicentre, randomised, parallel group, sham-controlled, double-masked, dose-ranging study, investigating two doses of OPT-302 in combination with ranibizumab compared with ranibizumab with sham, over six consecutive monthly dosing cycles in participants with neovascular (wet) AMD.
Study identification
- NCT ID
- NCT03345082
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 366 participants
Conditions and interventions
Conditions
Interventions
- OPT-302 Biological
- ranibizumab Biological
- sham intravitreal injection Other
Biological · Other
Eligibility (public fields only)
- Age range
- 50 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Nov 6, 2017 (Actual)
- Primary completion
- May 14, 2019 (Actual)
- Completion
- May 14, 2019 (Actual)
- Last update posted
- Jan 12, 2021
2017 – 2019
United States locations
- U.S. sites
- 55
- U.S. states
- 21
- U.S. cities
- 52
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Opthea Investigational Site | Phoenix | Arizona | 85014 | — |
| Opthea Investigational Site | Phoenix | Arizona | 85020 | — |
| Opthea Investigational Site | Beverly Hills | California | 90211 | — |
| Opthea Investigational Site | Encino | California | 91436 | — |
| Opthea Investigational Site | Palm Desert | California | 92260 | — |
| Opthea Investigational Site | Redlands | California | 92374 | — |
| Opthea Study Site | Sacramento | California | 95819 | — |
| Opthea Investigational Site | Sacramento | California | 95841 | — |
| Opthea Investigational Site | San Diego | California | 94143 | — |
| Opthea Investigational Site | Santa Ana | California | 92705 | — |
| Opthea Investigational Site | Santa Barbara | California | 93103 | — |
| Opthea Investigational Site | Santa Maria | California | 93454 | — |
| Opthea Investigational Site | Colorado Springs | Colorado | 80909 | — |
| Opthea Investigational Site | Golden | Colorado | 80401 | — |
| Opthea Investigational Site | Boynton Beach | Florida | 33426 | — |
| Opthea Investigational Site | Fort Myers | Florida | 33907 | — |
| Opthea Investigational Site | Fort Myers | Florida | 33912 | — |
| Opthea Investigational Site | Melbourne | Florida | 32901 | — |
| Opthea Investigational Site | Pensacola | Florida | 32503 | — |
| Opthea Investigational Site | St. Petersburg | Florida | 33703 | — |
| Opthea Investigational Site | Tallahassee | Florida | 32308 | — |
| Opthea Investigational Site | Winter Haven | Florida | 33880 | — |
| Opthea Investigational Site | Augusta | Georgia | 30909 | — |
| Opthea Investigational Site | Shawnee Mission | Kansas | 66204 | — |
| Opthea Investigational Site | Wichita | Kansas | 67214 | — |
| Opthea Investigational Site | Paducah | Kentucky | 42001 | — |
| Opthea Investigational Site | Baltimore | Maryland | 21204 | — |
| Opthea Investigational Site | Grand Rapids | Michigan | 49546 | — |
| Opthea Investigational Site | Las Vegas | Nevada | 89144 | — |
| Opthea Investigational Site | Reno | Nevada | 89502 | — |
| Opthea Investigational Site | Edison | New Jersey | 08820 | — |
| Opthea Investigational Site | Teaneck | New Jersey | 07666 | — |
| Opthea Investigational Site | Albuquerque | New Mexico | 87109 | — |
| Opthea Investigational Site | Lynbrook | New York | 11563 | — |
| Opthea Investigational Site | Rochester | New York | 14620 | — |
| Opthea Investigational Site | Syracuse | New York | 13224 | — |
| Opthea Investigational Site | Asheville | North Carolina | 28803 | — |
| Opthea Investigational Site | Charlotte | North Carolina | 28210 | — |
| Opthea Investigational Site | Cleveland | Ohio | 44195 | — |
| Opthea Investigational Site | Columbus | Ohio | 43212 | — |
| Opthea Investigational Site | Portland | Oregon | 97239 | — |
| Opthea Investigational Site | Camp Hill | Pennsylvania | 17011 | — |
| Opthea Investigational Site | Kingston | Pennsylvania | 18704 | — |
| Opthea Investigational Site | Philadelphia | Pennsylvania | 19107 | — |
| Opthea Investigational Site | Ladson | South Carolina | 29456 | — |
| Opthea Investigational Site | West Columbia | South Carolina | 29169 | — |
| Opthea Investigational Site | Abilene | Texas | 79606 | — |
| Opthea Investigational Site | Austin | Texas | 78705 | — |
| Opthea Investigational Site | Houston | Texas | 77030 | — |
| Opthea Investigational Site | San Antonio | Texas | 78240 | — |
| Opthea Investigational Site | The Woodlands | Texas | 77384 | — |
| Opthea Investigational Site | Willow Park | Texas | 76087 | — |
| Opthea Investigational Site | Fairfax | Virginia | 22031 | — |
| Opthea Investigational Site | Virginia Beach | Virginia | 23462 | — |
| Opthea Investigational Site | Silverdale | Washington | 98383 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 53 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT03345082, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jan 12, 2021 · Synced Oct 30, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT03345082 live on ClinicalTrials.gov.