ClinicalTrials.gov record
A Maintenance and Long-Term Extension Study of the Efficacy and Safety of Upadacitinib (ABT-494) in Participants With Crohn's Disease Who Completed the Studies M14-431 or M14-433
ClinicalTrials.gov ID: NCT03345823
Public ClinicalTrials.gov record NCT03345823. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Multicenter, Randomized, Double-Blind, Placebo-Controlled Maintenance and Long-Term Extension Study of the Efficacy and Safety of Upadacitinib (ABT-494) in Subjects With Crohn's Disease Who Completed the Studies M14-431 or M14-433
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
A multicenter study to evaluate the efficacy and safety of maintenance and long-term treatment administration of upadacitinib, an orally administered Janus kinase 1 inhibitor, in adult participants with Crohn's Disease.
Study identification
- NCT ID
- NCT03345823
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 747 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years to 75 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Mar 21, 2018 (Actual)
- Primary completion
- Sep 2027 (Estimated)
- Completion
- Sep 2027 (Estimated)
- Last update posted
- Apr 9, 2026
2018 – 2027
United States locations
- U.S. sites
- 123
- U.S. states
- 34
- U.S. cities
- 100
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| East View Medical Research, LLC /ID# 171132 | Mobile | Alabama | 36606 | — |
| CB Flock Research Corporation /ID# 166239 | Mobile | Alabama | 36608 | — |
| Delsol Research Management, Ll /Id# 170164 | Chandler | Arizona | 85224 | — |
| Duplicate_HonorHealth Research Institute - Shea /ID# 164725 | Scottsdale | Arizona | 85258 | — |
| Duplicate_Arizona Arthritis & Rheumatology Research, PLLC /ID# 164702 | Sun City | Arizona | 85306 | — |
| Southern California Res. Ctr. /ID# 169653 | Coronado | California | 92118-1408 | — |
| Citrus Valley Gastroenterology /ID# 166230 | Covina | California | 91722-3797 | — |
| Hoag Memorial Hosp Presbyterian /ID# 222538 | Irvine | California | 92618 | — |
| UC San Diego Health System /ID# 164763 | La Jolla | California | 92037 | — |
| United Medical Doctors /ID# 207458 | Los Alamitos | California | 90720-3309 | — |
| Gastrointestinal Biosciences Clinical Trials, LLC /ID# 164640 | Los Angeles | California | 90067-2001 | — |
| Facey Medical Foundation /ID# 203138 | Mission Hills | California | 91345 | — |
| United Medical Doctors - Murrieta /ID# 164602 | Murrieta | California | 92563 | — |
| Medical Assoc Research Grp /ID# 169704 | San Diego | California | 92123 | — |
| UCSF Medical Center - Mount Zion /ID# 202372 | San Francisco | California | 94115 | — |
| Univ of California San Francis /ID# 164653 | San Francisco | California | 94158 | — |
| Care Access Research /ID# 167765 | San Pablo | California | 94806 | — |
| Peak Gastroenterology Associates, PC /ID# 170166 | Colorado Springs | Colorado | 80907 | — |
| Delta Waves, Inc. /ID# 164656 | Colorado Springs | Colorado | 80918 | — |
| Western States Clinical Res /ID# 164625 | Wheat Ridge | Colorado | 80033-2896 | — |
| Gastroenterology Center of Connecticut /ID# 164614 | Hamden | Connecticut | 06518 | — |
| Advanced Research - Coral Springs /ID# 218019 | Coral Springs | Florida | 33067-3173 | — |
| Encore Borland-Groover Clinical Research /Id# 203500 | Jacksonville | Florida | 32256 | — |
| Ctr for Advanced Gastroenterol /ID# 165306 | Maitland | Florida | 32751-6108 | — |
| Crystal Pharmacology Research /ID# 166118 | Miami | Florida | 33165 | — |
| Coral Research Clinic /ID# 164604 | Miami | Florida | 33186-4643 | — |
| Advanced Research Institute, Inc /ID# 164601 | New Port Richey | Florida | 34653 | — |
| Endoscopic Research, Inc. /ID# 206139 | Orlando | Florida | 32803 | — |
| Omega Research Group /ID# 203482 | Orlando | Florida | 32808 | — |
| Duplicate_Clinical Research of West Florida, Inc /ID# 205828 | Tampa | Florida | 33606-1246 | — |
| Duplicate_Clinical Research of West Florida, Inc /ID# 208119 | Tampa | Florida | 33606-1246 | — |
| Clinical Research Trials of Florida, Inc. /ID# 203486 | Tampa | Florida | 33607 | — |
| Duplicate_AdventHealth Tampa /ID# 171181 | Tampa | Florida | 33613-4680 | — |
| Gastroenterology Associates of Central Georgia, LLC /ID# 165492 | Macon | Georgia | 31201 | — |
| Gastroenterology Consultants, P.C /ID# 218218 | Roswell | Georgia | 30076-4913 | — |
| Atlanta Gastroenterology Spec /ID# 164698 | Suwanee | Georgia | 30024 | — |
| Treasure Valley Medical Research /ID# 215030 | Boise | Idaho | 83706 | — |
| Duplicate_Rush University Medical Center /ID# 165470 | Chicago | Illinois | 60612 | — |
| Duplicate_University of Chicago Medicine /ID# 165509 | Chicago | Illinois | 60637-1426 | — |
| DuPage Medical Group /ID# 205320 | Downers Grove | Illinois | 60515-5509 | — |
| MediSphere Medical Research Center /ID# 166233 | Evansville | Indiana | 47714-8011 | — |
| Indianapolis Gastroenterology /ID# 164649 | Indianapolis | Indiana | 46237 | — |
| Aquiant Research /ID# 205505 | New Albany | Indiana | 47150-4053 | — |
| University of Iowa Hospitals and Clinics /ID# 165405 | Iowa City | Iowa | 52242 | — |
| Tri-State Gastroenterology /ID# 165469 | Crestview Hills | Kentucky | 41017 | — |
| Duplicate_University of Louisville /ID# 165391 | Louisville | Kentucky | 40202 | — |
| University of Louisville Hospital /ID# 168520 | Louisville | Kentucky | 40202 | — |
| Houma Digestive Health Special /ID# 164727 | Houma | Louisiana | 70360 | — |
| Nola Research Works, LLC /ID# 164612 | New Orleans | Louisiana | 70115 | — |
| Louisiana Research Center, LLC /ID# 164694 | Shreveport | Louisiana | 71105-6800 | — |
| Duplicate_Johns Hopkins University School of Medicine /ID# 211939 | Baltimore | Maryland | 21287-0010 | — |
| Metropolitan Gastroenterology Group - Chevy Chase /ID# 164647 | Chevy Chase | Maryland | 20815 | — |
| Gastro Center of Maryland /ID# 171180 | Columbia | Maryland | 21045 | — |
| Duplicate_Lahey Hospital and Medical Center /ID# 214724 | Burlington | Massachusetts | 01805 | — |
| University of Michigan Comprehensive Cancer Center Michigan Medicine /ID# 164654 | Ann Arbor | Michigan | 48109 | — |
| Clin Res Inst of Michigan, LLC /ID# 170163 | Chesterfield | Michigan | 48047 | — |
| Digestive Health Associates (DHA) - Farmington Hills /ID# 206101 | Farmington Hills | Michigan | 48334-3230 | — |
| Center for Digestive Health /ID# 164726 | Troy | Michigan | 48098-6363 | — |
| Mayo Clinic - Rochester /ID# 164691 | Rochester | Minnesota | 55905-0001 | — |
| Southern Therapy and Advanced Research (STAR) LLC /ID# 165295 | Jackson | Mississippi | 39216 | — |
| Quality Clinical Research Inc. /ID# 170162 | Omaha | Nebraska | 68114-3723 | — |
| CHI Health Research Center /ID# 168513 | Omaha | Nebraska | 68124 | — |
| Las Vegas Medical Research /ID# 168551 | Las Vegas | Nevada | 89113 | — |
| Cooper Gastroenterology at Fire Road /ID# 164641 | Egg Harbor | New Jersey | 08234 | — |
| Rutgers Robert Wood Johnson /ID# 166110 | New Brunswick | New Jersey | 08901 | — |
| NY Scientific /ID# 164630 | Brooklyn | New York | 11235 | — |
| United Health Services Hospitals, Inc /ID# 217483 | Johnson City | New York | 13790-2107 | — |
| NYU Langone Long Island Clinical Research Associates /ID# 164627 | Lake Success | New York | 11042 | — |
| The Mount Sinai Hospital /ID# 170256 | New York | New York | 10029 | — |
| Columbia Univ Medical Center /ID# 164692 | New York | New York | 10032-3725 | — |
| Gastoenterology Group of Rochester /ID# 166235 | Rochester | New York | 14618-5703 | — |
| Richmond University Medical Center /ID# 201858 | Staten Island | New York | 10310-1664 | — |
| Montefiore Medical Center - Moses Campus /ID# 166242 | The Bronx | New York | 10467 | — |
| Advantage Clinical Trials /ID# 168582 | The Bronx | New York | 10468 | — |
| Atrium Health Carolinas Medical Center /ID# 164632 | Charlotte | North Carolina | 28203 | — |
| Duplicate_PMG Research of Charlotte /ID# 171178 | Charlotte | North Carolina | 28209 | — |
| Wake Radiology UNC REX Healthcare - Raleigh Office /ID# 164752 | Raleigh | North Carolina | 27612 | — |
| Duplicate_Atrium Health Wake Forest Baptist Medical Center /ID# 164755 | Winston-Salem | North Carolina | 27157-0001 | — |
| Plains Clinical Research Center, LLC /ID# 170169 | Fargo | North Dakota | 58104-5925 | — |
| Gastro Health Research /ID# 164668 | Cincinnati | Ohio | 45219 | — |
| Duplicate_Duplicate_University Of Cincinnati Medical Center /ID# 164729 | Cincinnati | Ohio | 45267-0585 | — |
| Cleveland Clinic Main Campus /ID# 209230 | Cleveland | Ohio | 44195 | — |
| Ohio State University/ Gastroe /ID# 170159 | Columbus | Ohio | 43210 | — |
| Optimed Research, Ltd. /ID# 205625 | Columbus | Ohio | 43235 | — |
| Hometown Urgent Care and Resea /ID# 201289 | Dayton | Ohio | 45424 | — |
| Dayton Gastroenterology, Inc. /ID# 167623 | Englewood | Ohio | 45415 | — |
| Great Lakes Gastroenterology Research, LLC /ID# 202006 | Mentor | Ohio | 44060-6211 | — |
| Digestive Disease Specialists /ID# 201063 | Oklahoma City | Oklahoma | 73112 | — |
| Options Health Research, LLC /ID# 164704 | Tulsa | Oklahoma | 74104 | — |
| Healthcare Research Consultant /ID# 166244 | Tulsa | Oklahoma | 74135 | — |
| University of Pennsylvania /ID# 168406 | Philadelphia | Pennsylvania | 19104-5502 | — |
| Duplicate_Thomas Jefferson University /ID# 168003 | Philadelphia | Pennsylvania | 19107-4414 | — |
| Pharmacorp Clinical Trials /ID# 165008 | Charleston | South Carolina | 29412 | — |
| Gastroenterology Associates, P.A. of Greenville /ID# 164643 | Greenville | South Carolina | 29607 | — |
| Rapid City Medical Center - GI Research /ID# 201733 | Rapid City | South Dakota | 57701 | — |
| Gastro One /ID# 164730 | Cordova | Tennessee | 38018 | — |
| Duplicate_East Tennessee Research Institute /ID# 203614 | Johnson City | Tennessee | 37604 | — |
| Quality Medical Research /ID# 205264 | Nashville | Tennessee | 37211 | — |
| Vanderbilt University Medical Center /ID# 164607 | Nashville | Tennessee | 37232-0011 | — |
| TX Clinical Research Institute /ID# 164719 | Arlington | Texas | 76012 | — |
| Inquest Clinical Research /ID# 164676 | Baytown | Texas | 77521-2415 | — |
| GI Alliance /ID# 209803 | Cedar Park | Texas | 78613 | — |
| Baylor Scott & White Center for Inflammatory Bowel Diseases /ID# 170161 | Dallas | Texas | 75246 | — |
| Baylor College of Medicine /ID# 164609 | Houston | Texas | 77030 | — |
| Centex Studies, Inc. - Houston /ID# 201212 | Houston | Texas | 77058 | — |
| GI Specialists of Houston /ID# 202340 | Houston | Texas | 77070-4347 | — |
| Caprock Gastro Research - Lubbock - 80th Street /ID# 215436 | Lubbock | Texas | 79424 | — |
| Clinical Associates in Research Therapeutics of America, LLC /ID# 164675 | San Antonio | Texas | 78212 | — |
| Southern Star Research Institute, LLC /ID# 169756 | San Antonio | Texas | 78229-5390 | — |
| Carl R. Meisner Medical Clinic /ID# 171057 | Sugar Land | Texas | 77478 | — |
| Tyler Research Institute, LLC /ID# 168679 | Tyler | Texas | 75701 | — |
| Gastro Health & Nutrition - Victoria /ID# 167810 | Victoria | Texas | 77904 | — |
| Texas Digestive Disease Consultants /ID# 209954 | Webster | Texas | 77598 | — |
| HP Clinical Research /ID# 164631 | Bountiful | Utah | 84010 | — |
| Advanced Research Institute /ID# 164689 | Ogden | Utah | 84405 | — |
| Duplicate_Care Access Research /ID# 164685 | Salt Lake City | Utah | 84124-1377 | — |
| Duplicate_Velocity Clinical Research - Salt Lake City /ID# 166113 | West Jordan | Utah | 84088 | — |
| Texas Digestive Disease Consultants, PLLC dba GI Alliance /ID# 164728 | Bellevue | Washington | 98004 | — |
| Virginia Mason Hospital & Medical Center /ID# 164862 | Seattle | Washington | 98101 | — |
| University of Washington /ID# 164646 | Seattle | Washington | 98109 | — |
| The Vancouver Clinic, INC. PS /ID# 164874 | Vancouver | Washington | 98664 | — |
| Froedtert Memorial Lutheran Hospital /ID# 202285 | Milwaukee | Wisconsin | 53226-3522 | — |
| Allegiance Research Specialists /ID# 165298 | Wauwatosa | Wisconsin | 53226 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 343 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT03345823, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Apr 9, 2026 · Synced Oct 29, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT03345823 live on ClinicalTrials.gov.