ClinicalTrials.gov record
A Maintenance and Long-Term Extension Study of the Efficacy and Safety of Upadacitinib (ABT-494) in Participants With Crohn's Disease Who Completed the Studies M14-431 or M14-433
ClinicalTrials.gov ID: NCT03345823
Public ClinicalTrials.gov record NCT03345823. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
ClinicalTrials.gov public records Last synced May 6, 2026, 8:23 AM EDT
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Multicenter, Randomized, Double-Blind, Placebo-Controlled Maintenance and Long-Term Extension Study of the Efficacy and Safety of Upadacitinib (ABT-494) in Subjects With Crohn's Disease Who Completed the Studies M14-431 or M14-433
Study identification
- NCT ID
- NCT03345823
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Lead sponsor
- AbbVie
- Industry
- Enrollment
- 747 participants
Conditions and interventions
Conditions
Interventions
- Placebo for Upadacitinib Drug
- Upadacitinib Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years to 75 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Mar 20, 2018
- Primary completion
- Aug 31, 2027
- Completion
- Aug 31, 2027
- Last update posted
- Apr 8, 2026
2018 – 2027
United States locations
- U.S. sites
- 123
- U.S. states
- 34
- U.S. cities
- 100
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| East View Medical Research, LLC /ID# 171132 | Mobile | Alabama | 36606 | — |
| CB Flock Research Corporation /ID# 166239 | Mobile | Alabama | 36608 | — |
| Delsol Research Management, Ll /Id# 170164 | Chandler | Arizona | 85224 | — |
| Duplicate_HonorHealth Research Institute - Shea /ID# 164725 | Scottsdale | Arizona | 85258 | — |
| Duplicate_Arizona Arthritis & Rheumatology Research, PLLC /ID# 164702 | Sun City | Arizona | 85306 | — |
| Southern California Res. Ctr. /ID# 169653 | Coronado | California | 92118-1408 | — |
| Citrus Valley Gastroenterology /ID# 166230 | Covina | California | 91722-3797 | — |
| Hoag Memorial Hosp Presbyterian /ID# 222538 | Irvine | California | 92618 | — |
| UC San Diego Health System /ID# 164763 | La Jolla | California | 92037 | — |
| United Medical Doctors /ID# 207458 | Los Alamitos | California | 90720-3309 | — |
| Gastrointestinal Biosciences Clinical Trials, LLC /ID# 164640 | Los Angeles | California | 90067-2001 | — |
| Facey Medical Foundation /ID# 203138 | Mission Hills | California | 91345 | — |
| United Medical Doctors - Murrieta /ID# 164602 | Murrieta | California | 92563 | — |
| Medical Assoc Research Grp /ID# 169704 | San Diego | California | 92123 | — |
| UCSF Medical Center - Mount Zion /ID# 202372 | San Francisco | California | 94115 | — |
| Univ of California San Francis /ID# 164653 | San Francisco | California | 94158 | — |
| Care Access Research /ID# 167765 | San Pablo | California | 94806 | — |
| Peak Gastroenterology Associates, PC /ID# 170166 | Colorado Springs | Colorado | 80907 | — |
| Delta Waves, Inc. /ID# 164656 | Colorado Springs | Colorado | 80918 | — |
| Western States Clinical Res /ID# 164625 | Wheat Ridge | Colorado | 80033-2896 | — |
| Gastroenterology Center of Connecticut /ID# 164614 | Hamden | Connecticut | 06518 | — |
| Advanced Research - Coral Springs /ID# 218019 | Coral Springs | Florida | 33067-3173 | — |
| Encore Borland-Groover Clinical Research /Id# 203500 | Jacksonville | Florida | 32256 | — |
| Ctr for Advanced Gastroenterol /ID# 165306 | Maitland | Florida | 32751-6108 | — |
| Crystal Pharmacology Research /ID# 166118 | Miami | Florida | 33165 | — |
| Coral Research Clinic /ID# 164604 | Miami | Florida | 33186-4643 | — |
| Advanced Research Institute, Inc /ID# 164601 | New Port Richey | Florida | 34653 | — |
| Endoscopic Research, Inc. /ID# 206139 | Orlando | Florida | 32803 | — |
| Omega Research Group /ID# 203482 | Orlando | Florida | 32808 | — |
| Duplicate_Clinical Research of West Florida, Inc /ID# 205828 | Tampa | Florida | 33606-1246 | — |
| Duplicate_Clinical Research of West Florida, Inc /ID# 208119 | Tampa | Florida | 33606-1246 | — |
| Clinical Research Trials of Florida, Inc. /ID# 203486 | Tampa | Florida | 33607 | — |
| Duplicate_AdventHealth Tampa /ID# 171181 | Tampa | Florida | 33613-4680 | — |
| Gastroenterology Associates of Central Georgia, LLC /ID# 165492 | Macon | Georgia | 31201 | — |
| Gastroenterology Consultants, P.C /ID# 218218 | Roswell | Georgia | 30076-4913 | — |
| Atlanta Gastroenterology Spec /ID# 164698 | Suwanee | Georgia | 30024 | — |
| Treasure Valley Medical Research /ID# 215030 | Boise | Idaho | 83706 | — |
| Duplicate_Rush University Medical Center /ID# 165470 | Chicago | Illinois | 60612 | — |
| Duplicate_University of Chicago Medicine /ID# 165509 | Chicago | Illinois | 60637-1426 | — |
| DuPage Medical Group /ID# 205320 | Downers Grove | Illinois | 60515-5509 | — |
| MediSphere Medical Research Center /ID# 166233 | Evansville | Indiana | 47714-8011 | — |
| Indianapolis Gastroenterology /ID# 164649 | Indianapolis | Indiana | 46237 | — |
| Aquiant Research /ID# 205505 | New Albany | Indiana | 47150-4053 | — |
| University of Iowa Hospitals and Clinics /ID# 165405 | Iowa City | Iowa | 52242 | — |
| Tri-State Gastroenterology /ID# 165469 | Crestview Hills | Kentucky | 41017 | — |
| Duplicate_University of Louisville /ID# 165391 | Louisville | Kentucky | 40202 | — |
| University of Louisville Hospital /ID# 168520 | Louisville | Kentucky | 40202 | — |
| Houma Digestive Health Special /ID# 164727 | Houma | Louisiana | 70360 | — |
| Nola Research Works, LLC /ID# 164612 | New Orleans | Louisiana | 70115 | — |
| Louisiana Research Center, LLC /ID# 164694 | Shreveport | Louisiana | 71105-6800 | — |
| Duplicate_Johns Hopkins University School of Medicine /ID# 211939 | Baltimore | Maryland | 21287-0010 | — |
| Metropolitan Gastroenterology Group - Chevy Chase /ID# 164647 | Chevy Chase | Maryland | 20815 | — |
| Gastro Center of Maryland /ID# 171180 | Columbia | Maryland | 21045 | — |
| Duplicate_Lahey Hospital and Medical Center /ID# 214724 | Burlington | Massachusetts | 01805 | — |
| University of Michigan Comprehensive Cancer Center Michigan Medicine /ID# 164654 | Ann Arbor | Michigan | 48109 | — |
| Clin Res Inst of Michigan, LLC /ID# 170163 | Chesterfield | Michigan | 48047 | — |
| Digestive Health Associates (DHA) - Farmington Hills /ID# 206101 | Farmington Hills | Michigan | 48334-3230 | — |
| Center for Digestive Health /ID# 164726 | Troy | Michigan | 48098-6363 | — |
| Mayo Clinic - Rochester /ID# 164691 | Rochester | Minnesota | 55905-0001 | — |
| Southern Therapy and Advanced Research (STAR) LLC /ID# 165295 | Jackson | Mississippi | 39216 | — |
| Quality Clinical Research Inc. /ID# 170162 | Omaha | Nebraska | 68114-3723 | — |
| CHI Health Research Center /ID# 168513 | Omaha | Nebraska | 68124 | — |
| Las Vegas Medical Research /ID# 168551 | Las Vegas | Nevada | 89113 | — |
| Cooper Gastroenterology at Fire Road /ID# 164641 | Egg Harbor | New Jersey | 08234 | — |
| Rutgers Robert Wood Johnson /ID# 166110 | New Brunswick | New Jersey | 08901 | — |
| NY Scientific /ID# 164630 | Brooklyn | New York | 11235 | — |
| United Health Services Hospitals, Inc /ID# 217483 | Johnson City | New York | 13790-2107 | — |
| NYU Langone Long Island Clinical Research Associates /ID# 164627 | Lake Success | New York | 11042 | — |
| The Mount Sinai Hospital /ID# 170256 | New York | New York | 10029 | — |
| Columbia Univ Medical Center /ID# 164692 | New York | New York | 10032-3725 | — |
| Gastoenterology Group of Rochester /ID# 166235 | Rochester | New York | 14618-5703 | — |
| Richmond University Medical Center /ID# 201858 | Staten Island | New York | 10310-1664 | — |
| Montefiore Medical Center - Moses Campus /ID# 166242 | The Bronx | New York | 10467 | — |
| Advantage Clinical Trials /ID# 168582 | The Bronx | New York | 10468 | — |
| Atrium Health Carolinas Medical Center /ID# 164632 | Charlotte | North Carolina | 28203 | — |
| Duplicate_PMG Research of Charlotte /ID# 171178 | Charlotte | North Carolina | 28209 | — |
| Wake Radiology UNC REX Healthcare - Raleigh Office /ID# 164752 | Raleigh | North Carolina | 27612 | — |
| Duplicate_Atrium Health Wake Forest Baptist Medical Center /ID# 164755 | Winston-Salem | North Carolina | 27157-0001 | — |
| Plains Clinical Research Center, LLC /ID# 170169 | Fargo | North Dakota | 58104-5925 | — |
| Gastro Health Research /ID# 164668 | Cincinnati | Ohio | 45219 | — |
| Duplicate_Duplicate_University Of Cincinnati Medical Center /ID# 164729 | Cincinnati | Ohio | 45267-0585 | — |
| Cleveland Clinic Main Campus /ID# 209230 | Cleveland | Ohio | 44195 | — |
| Ohio State University/ Gastroe /ID# 170159 | Columbus | Ohio | 43210 | — |
| Optimed Research, Ltd. /ID# 205625 | Columbus | Ohio | 43235 | — |
| Hometown Urgent Care and Resea /ID# 201289 | Dayton | Ohio | 45424 | — |
| Dayton Gastroenterology, Inc. /ID# 167623 | Englewood | Ohio | 45415 | — |
| Great Lakes Gastroenterology Research, LLC /ID# 202006 | Mentor | Ohio | 44060-6211 | — |
| Digestive Disease Specialists /ID# 201063 | Oklahoma City | Oklahoma | 73112 | — |
| Options Health Research, LLC /ID# 164704 | Tulsa | Oklahoma | 74104 | — |
| Healthcare Research Consultant /ID# 166244 | Tulsa | Oklahoma | 74135 | — |
| University of Pennsylvania /ID# 168406 | Philadelphia | Pennsylvania | 19104-5502 | — |
| Duplicate_Thomas Jefferson University /ID# 168003 | Philadelphia | Pennsylvania | 19107-4414 | — |
| Pharmacorp Clinical Trials /ID# 165008 | Charleston | South Carolina | 29412 | — |
| Gastroenterology Associates, P.A. of Greenville /ID# 164643 | Greenville | South Carolina | 29607 | — |
| Rapid City Medical Center - GI Research /ID# 201733 | Rapid City | South Dakota | 57701 | — |
| Gastro One /ID# 164730 | Cordova | Tennessee | 38018 | — |
| Duplicate_East Tennessee Research Institute /ID# 203614 | Johnson City | Tennessee | 37604 | — |
| Quality Medical Research /ID# 205264 | Nashville | Tennessee | 37211 | — |
| Vanderbilt University Medical Center /ID# 164607 | Nashville | Tennessee | 37232-0011 | — |
| TX Clinical Research Institute /ID# 164719 | Arlington | Texas | 76012 | — |
| Inquest Clinical Research /ID# 164676 | Baytown | Texas | 77521-2415 | — |
| GI Alliance /ID# 209803 | Cedar Park | Texas | 78613 | — |
| Baylor Scott & White Center for Inflammatory Bowel Diseases /ID# 170161 | Dallas | Texas | 75246 | — |
| Baylor College of Medicine /ID# 164609 | Houston | Texas | 77030 | — |
| Centex Studies, Inc. - Houston /ID# 201212 | Houston | Texas | 77058 | — |
| GI Specialists of Houston /ID# 202340 | Houston | Texas | 77070-4347 | — |
| Caprock Gastro Research - Lubbock - 80th Street /ID# 215436 | Lubbock | Texas | 79424 | — |
| Clinical Associates in Research Therapeutics of America, LLC /ID# 164675 | San Antonio | Texas | 78212 | — |
| Southern Star Research Institute, LLC /ID# 169756 | San Antonio | Texas | 78229-5390 | — |
| Carl R. Meisner Medical Clinic /ID# 171057 | Sugar Land | Texas | 77478 | — |
| Tyler Research Institute, LLC /ID# 168679 | Tyler | Texas | 75701 | — |
| Gastro Health & Nutrition - Victoria /ID# 167810 | Victoria | Texas | 77904 | — |
| Texas Digestive Disease Consultants /ID# 209954 | Webster | Texas | 77598 | — |
| HP Clinical Research /ID# 164631 | Bountiful | Utah | 84010 | — |
| Advanced Research Institute /ID# 164689 | Ogden | Utah | 84405 | — |
| Duplicate_Care Access Research /ID# 164685 | Salt Lake City | Utah | 84124-1377 | — |
| Duplicate_Velocity Clinical Research - Salt Lake City /ID# 166113 | West Jordan | Utah | 84088 | — |
| Texas Digestive Disease Consultants, PLLC dba GI Alliance /ID# 164728 | Bellevue | Washington | 98004 | — |
| Virginia Mason Hospital & Medical Center /ID# 164862 | Seattle | Washington | 98101 | — |
| University of Washington /ID# 164646 | Seattle | Washington | 98109 | — |
| The Vancouver Clinic, INC. PS /ID# 164874 | Vancouver | Washington | 98664 | — |
| Froedtert Memorial Lutheran Hospital /ID# 202285 | Milwaukee | Wisconsin | 53226-3522 | — |
| Allegiance Research Specialists /ID# 165298 | Wauwatosa | Wisconsin | 53226 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 343 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT03345823, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Apr 8, 2026 · Synced May 6, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT03345823 live on ClinicalTrials.gov.