Safety and Efficacy of Pembrolizumab (MK-3475) in Children and Young Adults With Classical Hodgkin Lymphoma (MK-3475-667/KEYNOTE-667)
Public ClinicalTrials.gov record NCT03407144. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
An Open-label, Uncontrolled, Multicenter Phase II Trial of MK-3475 (Pembrolizumab) in Children and Young Adults With Newly Diagnosed Classical Hodgkin Lymphoma With Inadequate (Slow Early) Response to Frontline Chemotherapy (KEYNOTE 667)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This study will examine the safety and efficacy of pembrolizumab (MK-3475) in combination with chemotherapy in children and young adults with newly diagnosed classical Hodgkin Lymphoma (cHL) who are slow early responders (SERs) to frontline chemotherapy.
Study identification
- NCT ID
- NCT03407144
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 340 participants
Conditions and interventions
Conditions
Interventions
- pembrolizumab Biological
- doxorubicin Drug
- vinblastine Drug
- dacarbazine Drug
- cyclophosphamide Drug
- vincristine Drug
- prednisone/prednisolone Drug
- bleomycin Drug
- etoposide Drug
- Radiotherapy (RT) Radiation
Biological · Drug · Radiation
Eligibility (public fields only)
- Age range
- 3 Years to 25 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Apr 9, 2018 (Actual)
- Primary completion
- Feb 12, 2027 (Estimated)
- Completion
- Feb 12, 2027 (Estimated)
- Last update posted
- Oct 2, 2026
2018 – 2027
United States locations
- U.S. sites
- 47
- U.S. states
- 26
- U.S. cities
- 44
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Children's Hospital of Alabama ( Site 0023) | Birmingham | Alabama | 35233 | — |
| Phoenix Childrens Hospital ( Site 0034) | Phoenix | Arizona | 85016 | — |
| Arkansas Children's Hospital ( Site 0046) | Little Rock | Arkansas | 72202 | — |
| Kaiser - Orange County ( Site 0084) | Anaheim | California | 92806 | — |
| Kaiser Permanente ( Site 0082) | Downey | California | 90242 | — |
| Kaiser - Fontana ( Site 0083) | Fontana | California | 92335 | — |
| MemorialCare Health System - Long Beach Medical Center-Cherese Mari Laulhere Children's Village ( Si | Long Beach | California | 90806 | — |
| Kaiser Permanente Downey Medical Center ( Site 0024) | Los Angeles | California | 90027 | — |
| Kaiser Permanente - Oakland ( Site 0047) | Oakland | California | 94611 | — |
| Kaiser Permanente - Roseville ( Site 0080) | Roseville | California | 95661 | — |
| Kaiser Permanente - Santa Clara ( Site 0079) | Santa Clara | California | 95051 | — |
| Children's Hospital - Colorado ( Site 0028) | Aurora | Colorado | 80045 | — |
| Connecticut Children's Medical Center ( Site 0045) | Hartford | Connecticut | 06106 | — |
| Yale Cancer Center ( Site 0061) | New Haven | Connecticut | 06510 | — |
| Children's National Medical Center ( Site 0090) | Washington D.C. | District of Columbia | 20010 | — |
| University of Florida ( Site 0051) | Gainesville | Florida | 32610 | — |
| Memorial Regional Hospital/Joe DiMaggio Children's Hospital ( Site 0048) | Hollywood | Florida | 33021 | — |
| Arnold Palmer Hospital ( Site 0065) | Orlando | Florida | 32806 | — |
| Children's Healthcare of Atlanta at Egleston ( Site 0033) | Atlanta | Georgia | 30322 | — |
| University of Chicago ( Site 0066) | Chicago | Illinois | 60637 | — |
| Riley Hospital for Children ( Site 0091) | Indianapolis | Indiana | 46202 | — |
| University of Kentucky Markey Cancer Center ( Site 0057) | Lexington | Kentucky | 40536-0293 | — |
| University of Louisville-Norton Children's Hospital ( Site 0059) | Louisville | Kentucky | 40202 | — |
| Johns Hopkins University ( Site 0025) | Baltimore | Maryland | 21287 | — |
| Children's Hospital of Michigan ( Site 0056) | Detroit | Michigan | 48201 | — |
| Karmanos Cancer Institute ( Site 0002) | Detroit | Michigan | 48201 | — |
| Children's Hospitals and Clinics of Minnesota ( Site 0036) | Minneapolis | Minnesota | 55404 | — |
| St. Louis Children's Hospital ( Site 0038) | St Louis | Missouri | 63110 | — |
| Alliance for Childhood Diseases ( Site 0064) | Las Vegas | Nevada | 89135 | — |
| Hackensack University Medical Center ( Site 0026) | Hackensack | New Jersey | 07601 | — |
| Rutgers Cancer Institute of New Jersey ( Site 0027) | New Brunswick | New Jersey | 08901 | — |
| Roswell Park Cancer Institute ( Site 0040) | Buffalo | New York | 14263 | — |
| Cohen Children's Medical Center of New York ( Site 0052) | New Hyde Park | New York | 11040 | — |
| Columbia University/Herbert Irving Cancer Center ( Site 0063) | New York | New York | 10032 | — |
| Memorial Sloan Kettering Cancer Center ( Site 0060) | New York | New York | 10065 | — |
| Weill Cornell Medicine ( Site 0032) | New York | New York | 10065 | — |
| UNC Lineberger Comprehensive Cancer ( Site 0044) | Chapel Hill | North Carolina | 27514 | — |
| Cincinnati Children's Hospital Medical Center ( Site 0035) | Cincinnati | Ohio | 45229 | — |
| Nationwide Children's Hospital ( Site 0037) | Columbus | Ohio | 43205-2696 | — |
| St. Francis Hospital Cancer Center ( Site 0001) | Greenville | South Carolina | 29607 | — |
| Vanderbilt University Medical Center-Ingram Cancer Center ( Site 0054) | Nashville | Tennessee | 37232 | — |
| Dell Children's Medical Center Of Central Texas ( Site 0058) | Austin | Texas | 78723 | — |
| Children's Medical Center ( Site 0030) | Dallas | Texas | 75235 | — |
| Texas Children's Hospital ( Site 0042) | Houston | Texas | 77030 | — |
| Methodist HealthCare System of San Antonio Clinical Trials Office, Texas Transplant Institute ( Site | San Antonio | Texas | 78229 | — |
| Inova Fairfax Hospital ( Site 0031) | Falls Church | Virginia | 22042 | — |
| Seattle Childrens Hospital ( Site 0022) | Seattle | Washington | 98105 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 46 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT03407144, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Oct 2, 2026 · Synced Oct 24, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT03407144 live on ClinicalTrials.gov.