CANTATA: CB-839 With Cabozantinib vs. Cabozantinib With Placebo in Patients With Metastatic Renal Cell Carcinoma
Public ClinicalTrials.gov record NCT03428217. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Randomized, Double-Blind, Placebo-Controlled Phase 2 Clinical Trial Comparing CB-839 in Combination With Cabozantinib (CB-Cabo) vs. Placebo With Cabozantinib (Pbo-Cabo) in Patients With Advanced or Metastatic Renal Cell Carcinoma (RCC)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
Tthe primary objective of this study is to compare blinded Independent Radiology Committee (IRC)-adjudicated progression free survival (PFS) of patients treated with CB-839 + cabozantinib (CB-Cabo) versus placebo + cabozantinib (Pbo-Cabo) for advanced or metastatic clear-cell RCC (ccRCC).
Study identification
- NCT ID
- NCT03428217
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 444 participants
Conditions and interventions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Apr 24, 2018 (Actual)
- Primary completion
- Aug 31, 2020 (Actual)
- Completion
- Jul 16, 2021 (Actual)
- Last update posted
- Mar 20, 2023
2018 – 2021
United States locations
- U.S. sites
- 59
- U.S. states
- 29
- U.S. cities
- 54
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| University of Alabama at Birmingham | Birmingham | Alabama | 35294 | — |
| Mayo Clinic Cancer Center | Phoenix | Arizona | 85054 | — |
| The University of Arizona Cancer Center | Tucson | Arizona | 85724 | — |
| Cedars-Sinai Medical Center, Samuel Oschin Comprehensive Cancer Institute | Los Angeles | California | 90048 | — |
| Stanford Cancer Center | Palo Alto | California | 94304 | — |
| Salinas Valley Memorial Healthcare System | Salinas | California | 93901 | — |
| St. Joseph Heritage Healthcare | Santa Rosa | California | 95403 | — |
| Penrose Cancer Center, Research Department | Colorado Springs | Colorado | 80907 | — |
| Georgetown University Medical Center | Washington D.C. | District of Columbia | 20007 | — |
| Florida Cancer Specialists | Fort Myers | Florida | 33901 | — |
| University of Miami Sylvester Comprehensive Cancer Center | Miami | Florida | 33136 | — |
| Florida Cancer Specialists | St. Petersburg | Florida | 33705 | — |
| H.Lee Moffitt Cancer & Research Institute (Moffitt Cancer Center) | Tampa | Florida | 33612 | — |
| Emory Winship Cancer Institute | Atlanta | Georgia | 30322 | — |
| Georgia Cancer Center at Augusta University | Augusta | Georgia | 30912 | — |
| Northwest Georgia Oncology Centers, PC | Marietta | Georgia | 30060 | — |
| St. Luke's Mountain States Tumor Institute | Boise | Idaho | 83712 | — |
| Northwestern University | Chicago | Illinois | 60611 | — |
| University of Chicago | Chicago | Illinois | 60637 | — |
| NorthShore University HealthSystem | Evanston | Illinois | 60201 | — |
| AMITA Health Cancer Institute & Outpatient Center | Hinsdale | Illinois | 60521 | — |
| Orchard Healthcare Research, Inc. | Skokie | Illinois | 60077 | — |
| Northwestern Medicine Cancer Center Warrenville | Warrenville | Illinois | 60555 | — |
| Goshen Center for Cancer Care | Goshen | Indiana | 46526 | — |
| East Jefferson General Hospital | Metairie | Louisiana | 70006 | — |
| Ochsner Clinic Foundation | New Orleans | Louisiana | 70121 | — |
| University of Maryland, Greenebaum Comprehensive Cancer Center | Baltimore | Maryland | 21201 | — |
| Massachusetts General Hospital | Boston | Massachusetts | 02114 | — |
| Beth Israel Deaconess Medical Center | Boston | Massachusetts | 02215 | — |
| Dana-Farber Cancer Institute | Boston | Massachusetts | 02215 | — |
| Karmanos Cancer Institute | Detroit | Michigan | 48201 | — |
| HealthPartners Institute, Regions Cancer Care Center | Saint Paul | Minnesota | 55101 | — |
| Hattiesburg Clinic Hematology/Oncology | Hattiesburg | Mississippi | 39401 | — |
| University of Mississippi Medical Center | Jackson | Mississippi | 39216 | — |
| Mercy Hospital | Joplin | Missouri | 64804 | — |
| HCA Midwest Health | Kansas City | Missouri | 64132 | — |
| Comprehensive Cancer Centers of Nevada | Las Vegas | Nevada | 89148 | — |
| San Juan Oncology Associates, PC | Farmington | New Mexico | 87401 | — |
| Roswell Park Cancer Center | Buffalo | New York | 14263 | — |
| North Shore Hematology Oncology Associates PC dba NY Cancer and Blood Specialists | East Setauket | New York | 11733 | — |
| NYU Winthrop Hospital | Mineola | New York | 11501 | — |
| Northern Westchester Hospital | Mount Kisco | New York | 10549 | — |
| Stony Brook Cancer Center | Stony Brook | New York | 11794 | — |
| Levine Cancer Institute | Charlotte | North Carolina | 28204 | — |
| Duke University Medical Center | Durham | North Carolina | 27710 | — |
| INTEGRIS Cancer Institute of Oklahoma Proton Campus | Oklahoma City | Oklahoma | 73142 | — |
| Fox Chase Cancer Center | Philadelphia | Pennsylvania | 19111 | — |
| Allegheny General Hospital | Pittsburgh | Pennsylvania | 15212 | — |
| University of Pittsburgh Medical Center (UPMC) Hillman Cancer Center | Pittsburgh | Pennsylvania | 15232 | — |
| Medical University of South Carolina | Charleston | South Carolina | 29425 | — |
| Saint Francis Hospital Cancer Center | Greenville | South Carolina | 29607 | — |
| West Cancer Center | Germantown | Tennessee | 38138 | — |
| The Sarah Cannon Research Institute | Nashville | Tennessee | 37203 | — |
| Vanderbilt University Medical Center | Nashville | Tennessee | 37232 | — |
| The Center for Cancer and Blood Disorders | Fort Worth | Texas | 76104 | — |
| The University of Texas MD Anderson Cancer Center | Houston | Texas | 77030 | — |
| University of Utah, Huntsman Cancer Institute | Salt Lake City | Utah | 84112 | — |
| Kadlec Clinic Hematology and Oncology | Kennewick | Washington | 99336 | — |
| Froedtert Hospital and the Medical College of Wisconsin | Milwaukee | Wisconsin | 53226 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 74 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT03428217, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Mar 20, 2023 · Synced Oct 26, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT03428217 live on ClinicalTrials.gov.