A Study of ARRY-371797 (PF-07265803) in Patients With Symptomatic Dilated Cardiomyopathy Due to a Lamin A/C Gene Mutation
Public ClinicalTrials.gov record NCT03439514. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 3, Multinational, Randomized, Placebo-controlled Study of ARRY-371797 (PF-07265803) in Patients With Symptomatic Dilated Cardiomyopathy Due to a Lamin A/C Gene Mutation (REALM-DCM)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This is a randomized, double-blind, placebo-controlled study in patients with dilated cardiomyopathy (DCM) due to a mutation of the gene encoding the lamin A/C protein (LMNA). The study will further evaluate a dose level of study drug (ARRY-371797) that has shown preliminary efficacy and safety in this patient population. After the primary analysis has been performed, eligible patients may receive open-label treatment with ARRY-371797.
Study identification
- NCT ID
- NCT03439514
- Recruitment status
- Terminated
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 77 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Apr 17, 2018 (Actual)
- Primary completion
- Oct 13, 2022 (Actual)
- Completion
- Oct 13, 2022 (Actual)
- Last update posted
- Jan 9, 2024
2018 – 2022
United States locations
- U.S. sites
- 56
- U.S. states
- 21
- U.S. cities
- 29
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| University of Alabama at Birmingham Hospital | Birmingham | Alabama | 35233 | — |
| University of Alabama at Birmingham the Kirklin Clinic | Birmingham | Alabama | 35233 | — |
| IDS Pharmacy at UAB Hospital | Birmingham | Alabama | 35249 | — |
| Cardiovascular Clinical Trials Unit | Birmingham | Alabama | 35294 | — |
| CB Flock Research Corporation | Mobile | Alabama | 36608 | — |
| Chandler Regional Medical Center | Chandler | Arizona | 85224 | — |
| Valley Heart Rhythm Specialists, PLLC | Chandler | Arizona | 85224 | — |
| Cardiovascular and Stem Cell Consultants | Gilbert | Arizona | 85297-0425 | — |
| Cardiovascular Research Clinic | Gilbert | Arizona | 85297-0425 | — |
| Dignity Health, Mercy Gilbert Medical Center | Gilbert | Arizona | 85297-0425 | — |
| Mercy Gilbert Medical Center | Gilbert | Arizona | 85297 | — |
| Children's Clinic | Tucson | Arizona | 85712 | — |
| Banner - Banner University Medical Center South | Tucson | Arizona | 85713 | — |
| Banner - University Medical Center Tucson | Tucson | Arizona | 85719 | — |
| Banner University Medicine North | Tucson | Arizona | 85719 | — |
| Banner University Medical Center Tuscon | Tucson | Arizona | 85724 | — |
| University of Arizona Sarver Heart Center | Tucson | Arizona | 85724 | — |
| Ahmanson Cardiomyopathy Center Cardiovascular Genetics | Los Angeles | California | 90095 | — |
| Stanford Hospital and Clinics | Stanford | California | 94305 | — |
| University of Colorado Academic Offices Building | Aurora | Colorado | 80045 | — |
| University of Colorado Clinical and Translational Research Center | Aurora | Colorado | 80045 | — |
| University of Colorado Hospital | Aurora | Colorado | 80045 | — |
| Medstar Washington Hospital Center | Washington D.C. | District of Columbia | 20010 | — |
| Innovative Research of West Florida | Clearwater | Florida | 33756 | — |
| University of South Florida | Tampa | Florida | 33606-3601 | — |
| USF Health | Tampa | Florida | 33606 | — |
| Florida Cardiovascular Institute PA | Tampa | Florida | 33609 | — |
| Centers for Heart Failure Therapy | Atlanta | Georgia | 30322 | — |
| Emory University Hospital | Atlanta | Georgia | 30322 | — |
| Columbus Cardiology Associates Research - Centricity Research - HyperCore - PPDS | Columbus | Georgia | 31904-6877 | — |
| Columbus Cardiology Associates Research - IACT - HyperCore - PPDS | Columbus | Georgia | 31904-6877 | — |
| Columbus Regional Research Institute at Talbotton - Centricity Research - HyperCore - PPDS | Columbus | Georgia | 31904-8946 | — |
| Columbus Regional Research Institute | Columbus | Georgia | 31904 | — |
| Saint Luke's Idaho Cardiology Associates | Boise | Idaho | 83712-6246 | — |
| Brigham and Women's Hospital | Boston | Massachusetts | 02115 | — |
| MyMichigan Medical Center Midland | Midland | Michigan | 48670 | — |
| Washington University Center For Advanced Medicine | St Louis | Missouri | 63110 | — |
| Washington University Center for Outpatient Health | St Louis | Missouri | 63110 | — |
| Washington University School of Medicine | St Louis | Missouri | 63110 | — |
| Rutgers New Jersey Medical School - Doctors Office Center | Newark | New Jersey | 07103 | — |
| Newark Beth Israel Medical Center | Newark | New Jersey | 07112 | — |
| NYU School of Medicine / NYU Langone Health | New York | New York | 10016 | — |
| Columbia University Irving Medical Center | New York | New York | 10032 | — |
| Columbia University/Presbyterian Hospital - Vivian & Seymour Milstein Family Heart Center | New York | New York | 10032 | — |
| The Cleveland Clinic Foundation | Cleveland | Ohio | 44195 | — |
| Ohio State University Wexner Medical Center | Columbus | Ohio | 43210 | — |
| University of Pennsylvania Hospital | Philadelphia | Pennsylvania | 19104 | — |
| Medical University of South Carolina - PPDS | Charleston | South Carolina | 29425-8911 | — |
| Medical University of South Carolina - PPDS | Charleston | South Carolina | 29425 | — |
| Stern Cardiovascular Foundation Inc | Germantown | Tennessee | 38138 | — |
| Tennessee Center for Clinical Trials | Tullahoma | Tennessee | 37388 | — |
| Baylor Scott and White Heart and Vascular Hospital | Dallas | Texas | 75226 | — |
| Baylor Annette C and Harold C Simmons Transplant Institute | Dallas | Texas | 75246 | — |
| Intermountain Medical Center | Murray | Utah | 84107 | — |
| University of Washington Medical Center | Seattle | Washington | 98195 | — |
| Meriter Hospital | Madison | Wisconsin | 53713 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 51 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT03439514, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jan 9, 2024 · Synced Oct 21, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT03439514 live on ClinicalTrials.gov.