Pathogenetic Basis of Aortopathy and Aortic Valve Disease
Public ClinicalTrials.gov record NCT03440697. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The main purpose of this study is to define the complex genetic and pathogenic basis of thoracic aortic aneurysm (TAA) and other forms of aortopathy and/or aortic valve disease by identifying novel disease-causing genes and by identifying important genetic modifiers for aortic and aortic valve disease severity.
Study identification
- NCT ID
- NCT03440697
- Recruitment status
- Active, not recruiting
- Study type
- Observational
- Phase
- Not listed
- Enrollment
- 3,000 participants
Conditions and interventions
Conditions
- Aortopathies
- Thoracic Aortic Aneurysm
- Aortic Valve Disease
- Thoracic Aortic Disease
- Thoracic Aortic Dissection
- Thoracic Aortic Rupture
- Ascending Aortic Disease
- Descending Aortic Disease
- Ascending Aortic Aneurysm
- Descending Aortic Aneurysm
- Marfan Syndrome
- Loeys-Dietz Syndrome
- Vascular Ehlers-Danlos Syndrome
- Shprintzen-Goldberg Syndrome
- Turner Syndrome
- PHACE Syndrome
- Autosomal Recessive Cutis Laxa
- Congenital Contractural Arachnodactyly
- Arterial Tortuosity Syndrome
- Bicuspid Aortic Valve-Associated Aortopathy
- Bicuspid Aortic Valve
- Familial Thoracic Aortic Aneurysm and Aortic Dissection
Interventions
Not listed
Eligibility (public fields only)
- Age range
- Not listed
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Dec 9, 2015
- Primary completion
- Dec 30, 2030
- Completion
- Dec 30, 2030
- Last update posted
- Feb 12, 2026
2015 – 2030
United States locations
- U.S. sites
- 2
- U.S. states
- 2
- U.S. cities
- 2
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Childrens Healthcare of Atlanta | Atlanta | Georgia | 30329 | — |
| IU School of Medicine | Indianapolis | Indiana | 46202 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT03440697, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Feb 12, 2026 · Synced Sep 6, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT03440697 live on ClinicalTrials.gov.