Efficacy and Safety of Etripamil for the Termination of Spontaneous Paroxysmal Supraventricular Tachycardia (PSVT).
Public ClinicalTrials.gov record NCT03464019. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
Multi-Centre, Randomized, Double-Blind, Placebo-Controlled, Efficacy, and Safety Study of Etripamil Nasal Spray for the Termination of Spontaneous Episodes of Paroxysmal Supraventricular Tachycardia. NODE 301 and RAPID Studies
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This was a three-part, multi-center, randomized, double-blind, placebo-controlled study to evaluate the efficacy and safety of etripamil nasal spray (NS) self-administered by participants who experienced an episode of paroxysmal supraventricular tachycardia (PSVT) in an at-home setting. NODE-301 Part 1 included participants that received the randomized study drug to treat an episode of PSVT until the 150th positively adjudicated PSVT episode. Part 2 (also referred as the RAPID study) included participants that did not receive the randomized study drug in Part 1 and newly enrolled participants until the 180th positively adjudicated PSVT episode in Part 2. The study continued for approximately 6 months after the 180th positively adjudicated PSVT episode in Part 2 and this extension is referred to as Part 3 (also referred to as RAPID Extension).
Study identification
- NCT ID
- NCT03464019
- Recruitment status
- Terminated
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 1,097 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jun 18, 2018 (Actual)
- Primary completion
- Jan 20, 2023 (Actual)
- Completion
- Jan 20, 2023 (Actual)
- Last update posted
- Jul 12, 2024
2018 – 2023
United States locations
- U.S. sites
- 54
- U.S. states
- 23
- U.S. cities
- 47
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Arizona Arrhythmia Research Center | Phoenix | Arizona | 85016 | — |
| Arkansas Cardiology | Little Rock | Arkansas | 72205 | — |
| University of Arkansas for Medical Sciences | Little Rock | Arkansas | 72205 | — |
| Medvin Clinical Research | Cerritos | California | 91722 | — |
| North Coast Cardiolog | Encinitas | California | 92024 | — |
| Titan Medical Research - Oceanside | Encinitas | California | 92024 | — |
| Los Alamitos Cardiovascular | Los Alamitos | California | 90720 | — |
| Amicis Research Center - Northridge | Northridge | California | 91324 | — |
| RESPIRE Research | Palm Springs | California | 92262 | — |
| South Denver Cardiology Associates, P.C | Littleton | Colorado | 80120 | — |
| Cardiology Associates of Fairfield County | Norwalk | Connecticut | 06905 | — |
| FWD Clinical Research | Boca Raton | Florida | 33486 | — |
| Baptist Health Ambulatory Services d/b/a | Jacksonville | Florida | 32207 | — |
| United Health Research, LLC | Miami | Florida | 33144 | — |
| IACT Health | Columbus | Georgia | 31904 | — |
| Piedmont Heart Institute- Fayetteville | Fayetteville | Georgia | 30214 | — |
| Piedmont Heart Institute-Fayetteville | Fayetteville | Georgia | 30309 | — |
| Georgia Arrythmia Consultants&Research Institute | Macon | Georgia | 31201 | — |
| St. Luke's Idaho Cardiology Associates | Boise | Idaho | 83702 | — |
| Idaho Catalyst Clinical Research | Idaho Falls | Idaho | 83404 | — |
| AMITA Health Medical Group Heart & Vascular Elk Grpve Village | Elk Grove Village | Illinois | 60007 | — |
| Parkview Physicians Group - Cardiology | Fort Wayne | Indiana | 46845 | — |
| Mercy One Iowa Heart Center | West Des Moines | Iowa | 50266 | — |
| Clinical Trials of America, LLC - Monroe, LA | West Monroe | Louisiana | 71291 | — |
| MedStar Health Research Institute - Chesapeake Cardiovascular Associates | Baltimore | Maryland | 21237 | — |
| Sparrow Clinical Research Institute | Lansing | Michigan | 48912 | — |
| Revival Research Institute, LLC - Southgate, MI | Southgate | Michigan | 48195 | — |
| Mercy Research | St Louis | Missouri | 65804 | — |
| Cardiovascular Associates of the Delaware Valley - Elmer | Elmer | New Jersey | 08318 | — |
| Cardiovascular Associates of the Delaware Valley | Haddon Heights | New Jersey | 08035 | — |
| Atlantic Health System - Morristown Medical Center | Morristown | New Jersey | 07962 | — |
| Columbia University | New York | New York | 10032 | — |
| New York Presbyterian Hospital/Weill Cornell Medical Center | New York | New York | 10065 | — |
| Montefiore Medical Center | The Bronx | New York | 10467 | — |
| Cary Research Group, LLC | Cary | North Carolina | 27518 | — |
| Sanger Heart and Vascular Institute | Charlotte | North Carolina | 28204 | — |
| The Presbyterian Hospital DBA Novant Health Heart and Vascular Institute | Charlotte | North Carolina | 28204 | — |
| Hatton Institute for Research & Education, Trihealth, Inc. - Cardiology | Cincinnati | Ohio | 45242 | — |
| The Ohio State University (OSU) Wexner Medical Center | Columbus | Ohio | 43210 | — |
| Rama Research LLC | Marion | Ohio | 43302 | — |
| Heart House Research Foundation, LLC | Springfield | Ohio | 45505 | — |
| ProMedica Toledo Hospital | Toledo | Ohio | 43615 | — |
| Medical University of South Carolina (MUSC) | Charleston | South Carolina | 29425 | — |
| Prisma Health Midlands | Columbia | South Carolina | 29203 | — |
| Monument Health Clinical Research, a department of Monument Health Rapid City Hospital, Inc | Rapid City | South Dakota | 57701 | — |
| North Texas Research Associates | Allen | Texas | 75013 | — |
| Cardiovascular Clinic of North Texas | Denton | Texas | 76201 | — |
| Revival Research Institute, LLC | Denton | Texas | 76201 | — |
| Apex Trials Group | Fort Worth | Texas | 76104 | — |
| Angiocardiac Care of Texas | Houston | Texas | 77025 | — |
| Baylor College of Medicine | Houston | Texas | 77030 | — |
| Scott & White Memorial Hospital: Baylor Scott & White Research Institute | Temple | Texas | 76508 | — |
| Bay Area Heart | Webster | Texas | 77598 | — |
| Intermountain Medical Center | Murray | Utah | 84157-7000 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 107 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT03464019, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jul 12, 2024 · Synced Oct 24, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT03464019 live on ClinicalTrials.gov.