ClinicalTrials.gov record
Long-term Safety and Efficacy Extension Study for Participants With Advanced Tumors Who Are Currently on Treatment or in Follow-up in a Pembrolizumab (MK-3475) Study (MK-3475-587/KEYNOTE-587)
ClinicalTrials.gov ID: NCT03486873
Public ClinicalTrials.gov record NCT03486873. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
ClinicalTrials.gov public records Last synced May 7, 2026, 2:36 PM EDT
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Multicenter, Open-label, Phase 3 Study to Evaluate the Long-term Safety and Efficacy in Participants Who Are Currently on Treatment or in Follow-up in Studies That Include Pembrolizumab
Study identification
- NCT ID
- NCT03486873
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Lead sponsor
- Merck Sharp & Dohme LLC
- Industry
- Enrollment
- 3,500 participants
Conditions and interventions
Conditions
Interventions
- Lenvatinib Drug
- MK-4280 Drug
- MK-4280A Biological
- Olaparib Drug
- Pembrolizumab Drug
- Pembrolizumab (+) Berahyaluronidase alfa Biological
- Standard of Care (SOC) Drug
Drug · Biological
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Aug 20, 2018
- Primary completion
- Aug 3, 2043
- Completion
- Aug 3, 2043
- Last update posted
- Apr 23, 2026
2018 – 2043
United States locations
- U.S. sites
- 65
- U.S. states
- 31
- U.S. cities
- 59
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Arizona Cancer Center at UMC North ( Site 0018) | Tucson | Arizona | 85719 | Recruiting |
| Comprehensive Blood & Cancer Center [Bakersfield, CA] ( Site 0054) | Bakersfield | California | 93309 | Recruiting |
| California Cancer Associates for Research & Excellence ( Site 0016) | Fresno | California | 93720 | Completed |
| Providence Medical Foundation ( Site 0087) | Fullerton | California | 92835 | Completed |
| The Angeles Clinic and Research Institute ( Site 0005) | Los Angeles | California | 90025 | Completed |
| UCLA Hematology/Oncology - Westwood (Building 100) ( Site 0009) | Los Angeles | California | 90095 | Recruiting |
| University of California, Irvine (UCI) Health - UC Irvine Medical Center ( Site 0076) | Orange | California | 92868 | Recruiting |
| Stanford Cancer Center ( Site 0086) | Palo Alto | California | 94304 | Recruiting |
| UCSF Helen Diller Family Comprehensive Cancer Center ( Site 0004) | San Francisco | California | 94158 | Recruiting |
| Providence Saint John's Health Center ( Site 0059) | Santa Monica | California | 90404 | Recruiting |
| University of Colorado Cancer Center ( Site 0021) | Aurora | Colorado | 80045 | Recruiting |
| Yale Cancer Center ( Site 0014) | New Haven | Connecticut | 06511 | Active, not recruiting |
| Georgetown University Medical Center ( Site 0023) | Washington D.C. | District of Columbia | 20007 | Active, not recruiting |
| Holy Cross Hospital, Michael & Dianne Bienes Comp Cancer Ctr ( Site 0022) | Fort Lauderdale | Florida | 33308 | Recruiting |
| Baptist MD Anderson Cancer Center ( Site 0083) | Jacksonville | Florida | 32207 | Completed |
| Mount Sinai Medical Center Comprehensive Cancer Center ( Site 0031) | Miami Beach | Florida | 33140 | Recruiting |
| Moffitt Cancer Center ( Site 0011) | Tampa | Florida | 33612 | Completed |
| Emory School of Medicine ( Site 0013) | Atlanta | Georgia | 30322 | Completed |
| Augusta University ( Site 0077) | Augusta | Georgia | 30912 | Recruiting |
| Northwest Georgia Oncology Centers PC ( Site 0061) | Marietta | Georgia | 30060 | Recruiting |
| Kaiser Permanente Moanalua Medical Center ( Site 0063) | Honolulu | Hawaii | 96813 | Recruiting |
| The University of Chicago ( Site 0020) | Chicago | Illinois | 60637 | Recruiting |
| University of Iowa Hospital and Clinics ( Site 0026) | Iowa City | Iowa | 52242 | Recruiting |
| James Graham Brown Cancer Center ( Site 0058) | Louisville | Kentucky | 40202 | Recruiting |
| Mercy Health-Paducah Cancer Center ( Site 0084) | Paducah | Kentucky | 42003 | Recruiting |
| Women's Cancer Care ( Site 0088) | Covington | Louisiana | 70433 | Recruiting |
| MedStar Franklin Square Medical Center ( Site 0046) | Baltimore | Maryland | 21237 | Recruiting |
| Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins ( Site 0056) | Baltimore | Maryland | 21287 | Recruiting |
| Maryland Oncology Hematology (MOH) ( Site 8000) | Columbia | Maryland | 21044 | Recruiting |
| Massachusetts General Hospital ( Site 0041) | Boston | Massachusetts | 02114 | Recruiting |
| Dana-Farber Cancer Institute ( Site 0006) | Boston | Massachusetts | 02215 | Recruiting |
| Karmanos Cancer Institute ( Site 0047) | Detroit | Michigan | 48201 | Recruiting |
| Mayo Clinic in Rochester, Minnesota ( Site 0002) | Rochester | Minnesota | 55905 | Recruiting |
| Comprehensive Cancer Centers of Nevada ( Site 0043) | Las Vegas | Nevada | 89169 | Recruiting |
| John Theurer Cancer Center at Hackensack University Medical Center ( Site 0038) | Hackensack | New Jersey | 07601 | Completed |
| Cancer Institute of New Jersey ( Site 0025) | New Brunswick | New Jersey | 08901 | Recruiting |
| Laura and Isaac Perlmutter Cancer Center at NYU Langone Health ( Site 0032) | New York | New York | 10016 | Recruiting |
| Memorial Sloan Kettering Cancer Center ( Site 0012) | New York | New York | 10065 | Completed |
| White Plains Hospital-Center for Cancer Care ( Site 0069) | White Plains | New York | 10601 | Recruiting |
| WakeMed Cancer Care - Waverly Hematology & Medical Oncology ( Site 0074) | Cary | North Carolina | 27518 | Recruiting |
| University of North Carolina at Chapel Hill ( Site 0040) | Chapel Hill | North Carolina | 27599 | Recruiting |
| Levine Cancer Institute ( Site 0034) | Charlotte | North Carolina | 28204 | Active, not recruiting |
| Duke Cancer Center ( Site 0028) | Durham | North Carolina | 27710 | Recruiting |
| Sanford Fargo Medical Center-Roger Maris Cancer Center ( Site 0065) | Fargo | North Dakota | 58102 | Completed |
| University Hospitals ( Site 0044) | Cleveland | Ohio | 44106 | Completed |
| Oklahoma Cancer Specialists and Research Institute, LLC ( Site 0082) | Tulsa | Oklahoma | 74146 | Recruiting |
| Providence Portland Medical Center ( Site 0051) | Portland | Oregon | 97225 | Completed |
| St. Luke's University Health Network ( Site 0017) | Bethlehem | Pennsylvania | 18015 | Recruiting |
| University of Pennsylvania ( Site 0010) | Philadelphia | Pennsylvania | 19104 | Recruiting |
| Fox Chase Cancer Center ( Site 0042) | Philadelphia | Pennsylvania | 19111 | Recruiting |
| UPMC Hillman Cancer Center ( Site 0008) | Pittsburgh | Pennsylvania | 15232 | Recruiting |
| Saint Francis Health System ( Site 0089) | Greenville | South Carolina | 29607 | Recruiting |
| Sanford Cancer Center ( Site 0066) | Sioux Falls | South Dakota | 57104 | Completed |
| West Cancer Center and Research Institute ( Site 0055) | Germantown | Tennessee | 38138 | Completed |
| Vanderbilt Health One Hundred Oaks Diagnostic ( Site 0060) | Nashville | Tennessee | 37204 | Recruiting |
| Vanderbilt Ingram Cancer Center ( Site 0015) | Nashville | Tennessee | 37232 | Recruiting |
| Texas Oncology - Central/South Texas ( Site 8001) | Austin | Texas | 78745 | Recruiting |
| Texas Oncology-Baylor Sammons Cancer Center ( Site 0062) | Dallas | Texas | 75246 | Recruiting |
| University of Texas MD Anderson Cancer Center ( Site 0007) | Houston | Texas | 77030 | Recruiting |
| South Texas Accelerated Research Therapeutics, LLC (START) ( Site 0001) | San Antonio | Texas | 78229 | Recruiting |
| University of Virginia Health System ( Site 0035) | Charlottesville | Virginia | 22908 | Recruiting |
| Bon Secours St. Francis Medical Center-Oncology Research ( Site 0075) | Midlothian | Virginia | 23114 | Completed |
| VCU Health Adult Outpatient Pavillion ( Site 0080) | Richmond | Virginia | 23219 | Recruiting |
| Blue Ridge Cancer Care ( Site 0067) | Roanoke | Virginia | 24014 | Recruiting |
| Fred Hutchinson Cancer Center ( Site 0024) | Seattle | Washington | 98109 | Recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 714 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT03486873, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Apr 23, 2026 · Synced May 7, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete protocol, eligibility criteria, and contact information for NCT03486873 live on ClinicalTrials.gov.