Reducing Lung CongestIon Symptoms in Advanced Heart Failure
Public ClinicalTrials.gov record NCT03499236. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
RELIEVE-HF TRIAL: REducing Lung congestIon Symptoms Using the v-wavE Shunt in adVancEd Heart Failure
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The objective of the RELIEVE-HF study is to provide reasonable assurance of safety and effectiveness of the V-Wave Interatrial Shunt System by improving meaningful clinical outcomes in patients with New York Heart Association (NYHA) functional Class II, Class III, or ambulatory Class IV heart failure (HF), irrespective of left ventricular ejection fraction, who at baseline are treated with guideline-directed drug and device therapies.
Study identification
- NCT ID
- NCT03499236
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Not applicable
- Enrollment
- 605 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years to 99 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Sep 19, 2018 (Actual)
- Primary completion
- Oct 9, 2023 (Actual)
- Completion
- Oct 31, 2027 (Estimated)
- Last update posted
- Aug 19, 2025
2018 – 2027
United States locations
- U.S. sites
- 43
- U.S. states
- 19
- U.S. cities
- 38
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Abrazo Arizona Heart Hospital | Phoenix | Arizona | 85016 | — |
| Arizona Heart Rhythm Center | Phoenix | Arizona | 85016 | — |
| Scripps Health | La Jolla | California | 92037 | — |
| Long Beach Memorial Medical Center | Long Beach | California | 90806 | — |
| Keck Medical Center of USC | Los Angeles | California | 90033 | — |
| Cedars Sinai Medical Center | Los Angeles | California | 90211 | — |
| Kaiser Permanente San Francisco | San Francisco | California | 94118 | — |
| University of California, San Francisco | San Francisco | California | 94143 | — |
| Stanford Hospital | Stanford | California | 94305 | — |
| Los Robles Hospital & Medical Center | Thousand Oaks | California | 91360 | — |
| The Lundquist Institute (Harbor-UCLA) Medical Center | Torrance | California | 90502 | — |
| South Denver Cardiology | Littleton | Colorado | 80120 | — |
| Memorial Hospital | Jacksonville | Florida | 32216 | — |
| University of Miami | Miami | Florida | 33136 | — |
| First Coast Cardiovascular Institute | Orange Park | Florida | 32003 | — |
| Piedmont Hospital | Atlanta | Georgia | 30309 | — |
| Northeast Georgia Medical Center | Gainesville | Georgia | 30501 | — |
| Rush University Medical Center | Chicago | Illinois | 60612 | — |
| Midwest Cardiovascular Institute | Naperville | Illinois | 60540 | — |
| St Elizabeth Medical Center | Edgewood | Kentucky | 41017 | — |
| United Heart & Vascular Clinic | Saint Paul | Minnesota | 55102 | — |
| Nebraska Heart Institute | Lincoln | Nebraska | 68526 | — |
| Valley Health System | Ridgewood | New Jersey | 07450 | — |
| Weill Cornell | New York | New York | 10065 | — |
| Rochester General Health System | Rochester | New York | 14621 | — |
| Mission Hospital | Asheville | North Carolina | 28801 | — |
| North Carolina Heart & Vascular | Raleigh | North Carolina | 27607 | — |
| Summa Health | Akron | Ohio | 44304 | — |
| Lindner Center for Research and Education at The Christ Hospital | Cincinnati | Ohio | 45219 | — |
| Cleveland Clinic | Cleveland | Ohio | 80120 | — |
| The Ohio State University | Columbus | Ohio | 43210 | — |
| Penn State Milton S. Hershey Medical Center | Hershey | Pennsylvania | 17033 | — |
| UPMC Pinnacle / Pinnacle Health Cardiovascular Institute | Wormleysburg | Pennsylvania | 17043 | — |
| Medical University of South Carolina | Charleston | South Carolina | 29425 | — |
| Centennial Medical Center | Nashville | Tennessee | 37203 | — |
| Austin Heart | Austin | Texas | 78756 | — |
| Baylor College of Medicine | Houston | Texas | 77030 | — |
| Texas Heart Institute | Houston | Texas | 77030 | — |
| University of Texas Memorial Hermann | Houston | Texas | 77030 | — |
| Methodist Hospital | San Antonio | Texas | 78249 | — |
| Christus Mother Frances Hospital | Tyler | Texas | 75701 | — |
| University of Utah Hospital | Salt Lake City | Utah | 84132 | — |
| Chippenham Medical Center | Richmond | Virginia | 23225 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 40 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT03499236, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Aug 19, 2025 · Synced Oct 21, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT03499236 live on ClinicalTrials.gov.