ClinicalTrials.gov record
A Study to Compare the Efficacy and Safety of Intravitreal APL-2 Therapy With Sham Injections in Patients With Geographic Atrophy (GA) Secondary to Age-Related Macular Degeneration
ClinicalTrials.gov ID: NCT03525613
Public ClinicalTrials.gov record NCT03525613. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
ClinicalTrials.gov public records Last synced Apr 22, 2026, 11:18 AM EDT
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 3, Multi-Center, Randomized, Double-Masked, Sham-Controlled Study to Compare the Efficacy and Safety of Intravitreal Pegcetacoplan Therapy With Sham Injections in Patients With Geographic Atrophy (GA) Secondary to Age-Related Macular Degeneration (AMD)
Study identification
- NCT ID
- NCT03525613
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Lead sponsor
- Apellis Pharmaceuticals, Inc.
- Industry
- Enrollment
- 637 participants
Conditions and interventions
Conditions
Interventions
- APL-2 Drug
- Sham Procedure Other
Drug · Other
Eligibility (public fields only)
- Age range
- 60 Years and older
- Sex
- All
- Healthy volunteers
- Not listed
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Aug 30, 2018
- Primary completion
- Jun 27, 2021
- Completion
- Jun 27, 2022
- Last update posted
- Jul 5, 2023
2018 – 2022
United States locations
- U.S. sites
- 67
- U.S. states
- 27
- U.S. cities
- 59
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Arizona Retina & Vitreous Consultants | Phoenix | Arizona | 85021 | — |
| California Retina Consultants | Bakersfield | California | 93309 | — |
| Retina Vitreous Associates Medical Group | Beverly Hills | California | 90211 | — |
| Retinal Diagnostic Center | Campbell | California | 95508 | — |
| Retina Consultants of Orange County | Fullerton | California | 92835 | — |
| Atlantis Eyecare | Huntington Beach | California | 92647 | — |
| University of California, San Diego, Jacobs Retina | La Jolla | California | 92093 | — |
| Byers Eye Institute at Stanford, Stanford School of Medicine | Palo Alto | California | 94303 | — |
| Doheny Eye Center UCLA | Pasadena | California | 91105 | — |
| Retina Consultants San Diego | Poway | California | 92064 | — |
| Retinal Consultants Med Group, Inc. | Sacramento | California | 95819 | — |
| Orange County Retina Medical Group | Santa Ana | California | 92705 | — |
| California Retina Consultants | Santa Barbara | California | 93103 | — |
| Southwest Retina Research Center, LLC | Durango | Colorado | 81301 | — |
| Colorado Retina Associates | Golden | Colorado | 80401 | — |
| Retina Group of New England | Waterford | Connecticut | 06385 | — |
| Blue Ocean Clinical Research / The Macula Center | Clearwater | Florida | 33761 | — |
| National Ophthalmic Research Institute (Retina Consultants of Southwest Florida) | Fort Myers | Florida | 33912 | — |
| Bascom Palmer Eye Institute | Miami | Florida | 33136 | — |
| Bascom Palmer Eye Institute of Naples | Naples | Florida | 34103 | — |
| Retina Specialty Institute | Pensacola | Florida | 32503 | — |
| Center for Retina and Macular Disease | Winter Haven | Florida | 33880 | — |
| Southeast Retina Center, PC | Augusta | Georgia | 30909 | — |
| Gailey Eye Clinic Retina Center | Bloomington | Illinois | 61704 | — |
| Northwestern Feinberg School of Medicine | Chicago | Illinois | 60611 | — |
| Rush University Medical Center | Chicago | Illinois | 60612 | — |
| Midwest Eye Institute | Indianapolis | Indiana | 46290 | — |
| Retina and Vitreous Associates of Kentucky, PSC dba Retina Associates of Kentucky | Lexington | Kentucky | 40509 | — |
| Retina Associates New Orleans | Metairie | Louisiana | 70006 | — |
| The Retina Care Center | Baltimore | Maryland | 21209 | — |
| The Retina Group of Washington | Chevy Chase | Maryland | 20815 | — |
| Cumberland Valley Retina Center | Hagerstown | Maryland | 21740 | — |
| Mid Atlantic Retina Specialists | Hagerstown | Maryland | 21740 | — |
| Tufts Medical Center | Boston | Massachusetts | 02116 | — |
| New England Retina Consultants | Springfield | Massachusetts | 01107 | — |
| Michigan Medicine Kellogg Eye Center | Ann Arbor | Michigan | 48105 | — |
| Associated Retinal Consultants, P.C | Grand Rapids | Michigan | 49564 | — |
| VitreoRetinal Surgery PA | Minneapolis | Minnesota | 55435 | — |
| Sierra Eye Associates | Reno | Nevada | 89502 | — |
| Retina Center of NJ, LLC | Bloomfield | New Jersey | 07003 | — |
| NJ Retina | Toms River | New Jersey | 08755 | — |
| Vision Research Center Eye Associates of NM | Albuquerque | New Mexico | 87109 | — |
| Ophthalmic Consultants of Long Island | Lynbrook | New York | 11563 | — |
| New York Eye and Ear Infirmary of Mount Sinai | New York | New York | 10003 | — |
| Vitreous Retina Macula Consultants of NY | New York | New York | 10022 | — |
| Duke University, Duke Eye Center | Durham | North Carolina | 27710 | — |
| Research - Retina Vitreous Center | Edmond | Oklahoma | 73013 | — |
| Oregon Retina, LLP | Eugene | Oregon | 97405 | — |
| Mid Atlantic Retina | Bethlehem | Pennsylvania | 18017 | — |
| Retina Vitreous Consultants | Monroeville | Pennsylvania | 15146 | — |
| Mid Atlantic Retina, Wills Eye Hospital | Philadelphia | Pennsylvania | 19107 | — |
| AIO Visionary Eye Care | West Mifflin | Pennsylvania | 15122 | — |
| Charles Retina Institute | Germantown | Tennessee | 38138 | — |
| Tennessee Retina, PC | Nashville | Tennessee | 37203 | — |
| Retina Research Institute of Texas | Abilene | Texas | 79606 | — |
| Texas Retina Associates | Dallas | Texas | 75231 | — |
| Houston Eye Associates | Houston | Texas | 77025 | — |
| Retina Consultants of Houston, PA | Houston | Texas | 77030 | — |
| San Antonia Eye Center | San Antonio | Texas | 78215 | — |
| Medical Center Ophthalmology Associates | San Antonio | Texas | 78240 | — |
| Retina Associates of South Texas | San Antonio | Texas | 78240 | — |
| Retinal Consultants of San Antonio | San Antonio | Texas | 78240 | — |
| Brown Retina Institute | San Antonio | Texas | 78251 | — |
| Strategic Clinical Research Group | Willow Park | Texas | 76087 | — |
| University of Utah - John A. Moran Center | Salt Lake City | Utah | 84132 | — |
| Emerson Clinical Research Institute | Falls Church | Virginia | 22046 | — |
| University of Wisconsin | Madison | Wisconsin | 53705 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 45 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT03525613, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jul 5, 2023 · Synced Apr 22, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete protocol, eligibility criteria, and contact information for NCT03525613 live on ClinicalTrials.gov.