Efficacy of Daromun Neoadjuvant Intratumoral Treatment in Clinical Stage IIIB/C/D Melanoma Patients

ClinicalTrials.gov ID: NCT03567889

Public ClinicalTrials.gov record NCT03567889. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced May 18, 2026, 3:38 AM EDT

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Official title

An Open-Label, Randomized, Controlled Multi-Center Study of The Efficacy of Daromun (L19IL2 + L19TNF) Neoadjuvant Intratumoral Treatment Followed by Surgery and Adjuvant Therapy Versus Surgery and Adjuvant Therapy in Clinical Stage IIIB/C/D Melanoma Patients

Study identification

NCT ID: NCT03567889
Recruitment status: Recruiting
Study type: Interventional
Phase: Phase 3
Lead sponsor: Philogen S.p.A.; Industry
Enrollment: 186 participants

Conditions and interventions

Conditions

Interventions

Adjuvant therapy Drug
Daromun Drug
Surgery Procedure

Drug · Procedure

Eligibility (public fields only)

Age range: 18 Years and older
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Sep 19, 2018
Primary completion: Nov 30, 2027
Completion: Nov 30, 2031
Last update posted: Dec 16, 2025

2018 – 2031

United States locations

U.S. sites: 19
U.S. states: 15
U.S. cities: 19

Facility	City	State	ZIP	Site status
Mayo Clinic Hospital	Phoenix	Arizona	85054	Recruiting
UC San Diego Moores Cancer Center	La Jolla	California	92093	Active, not recruiting
UC Irvine Health-Chao Family Comprehensive Cancer Center	Orange	California	92868-3201	Active, not recruiting
Moffitt Cancer Center	Tampa	Florida	33612	Recruiting
Winship Cancer Institute, Emory university	Atlanta	Georgia	30322	Recruiting
Rush University Medical Center	Chicago	Illinois	60612	Active, not recruiting
University of Iowa Hospitals and Clinics	Iowa City	Iowa	52242	Active, not recruiting
Mayo Clinic	Rochester	Minnesota	55905	Recruiting
Rutgers Cancer Institute, 195 Little Albany Street	New Brunswick	New Jersey	08903	Recruiting
Ambulatory Care Center at NYC Langarone Health	New York	New York	10016	Active, not recruiting
Memorial Sloan Kettering Cancer Center - Main Campus	Ney York	New York	10065	Recruiting
Duke University Medical Center - Duke Cancer Center	Durham	North Carolina	27710	Recruiting
Ohio State University Wexner Medical Center	Columbus	Ohio	43210	Recruiting
St. Luke's Cancer Center, Clinical Trial, 3rd floor, 1600 St. Luke's Blvd.	Easton	Pennsylvania	18045	Active, not recruiting
Penn State Cancer Institute	Hershey	Pennsylvania	17033	Recruiting
Fox Chase Cancer Center 333 Cottman Avenue	Philadelphia	Pennsylvania	19111	Recruiting
The University of Texas M.D. Anderson Cancer Center	Houston	Texas	77030-4009	Recruiting
Huntsman Cancer Institute, University of Utah 2000 Circle of Hope	Salt Lake City, UT	Utah	84112	Recruiting
VCU - McGlothlin Medical Education Center	Richmond	Virginia	980037	Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 18 non-U.S. sites.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT03567889, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted Dec 16, 2025 · Synced May 18, 2026

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The complete protocol, eligibility criteria, and contact information for NCT03567889 live on ClinicalTrials.gov.

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