A Study to Evaluate the Efficacy and Safety of Faricimab (RO6867461) in Participants With Diabetic Macular Edema
Public ClinicalTrials.gov record NCT03622593. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase III, Multicenter, Randomized, Double-Masked, Active Comparator-Controlled Study to Evaluate the Efficacy and Safety of Faricimab (RO6867461) in Patients With Diabetic Macular Edema (RHINE)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This study will evaluate the efficacy, safety, and pharmacokinetics of faricimab administered at 8-week intervals or as specified in the protocol following treatment initiation, compared with aflibercept once every 8 weeks (Q8W), in participants with diabetic macular edema (DME).
Study identification
- NCT ID
- NCT03622593
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 951 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Oct 9, 2018 (Actual)
- Primary completion
- Oct 19, 2020 (Actual)
- Completion
- May 31, 2023 (Actual)
- Last update posted
- Jul 11, 2025
2018 – 2023
United States locations
- U.S. sites
- 50
- U.S. states
- 21
- U.S. cities
- 47
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Associated Retina Consultants | Phoenix | Arizona | 85020 | — |
| Retinal Research Institute, LLC | Phoenix | Arizona | 85053 | — |
| Northwest Arkansas Retina Associates | Springdale | Arkansas | 72764 | — |
| California Retina Consultants | Bakersfield | California | 93309 | — |
| Retina-Vitreous Associates Medical Group | Beverly Hills | California | 90211 | — |
| The Retina Partners | Encino | California | 91436 | — |
| Retina Consultants of Orange County | Fullerton | California | 92835 | — |
| Northern California Retina Vitreous Associates | Mountain View | California | 94040 | — |
| Retinal Consultants Med Group | Sacramento | California | 95825 | — |
| California Retina Consultants | Santa Barbara | California | 93103 | — |
| California Retina Consultants | Santa Maria | California | 93454 | — |
| Bay Area Retina Associates | Walnut Creek | California | 94598 | — |
| University of Colorado | Aurora | Colorado | 80045 | — |
| Retina Consultants of Southern | Colorado Springs | Colorado | 80909 | — |
| Retina Group of New England | Waterford | Connecticut | 06385 | — |
| Retina Group of Florida | Fort Lauderdale | Florida | 33308 | — |
| National Ophthalmic Research Institute | Fort Myers | Florida | 33912 | — |
| Florida Eye Associates | Melbourne | Florida | 32901 | — |
| Bascom Palmer Eye Institute | Palm Beach Gardens | Florida | 33418 | — |
| Fort Lauderdale Eye Institute | Plantation | Florida | 33324 | — |
| Retina Vitreous Assoc of FL | St. Petersburg | Florida | 33711 | — |
| Southeast Retina Center | Augusta | Georgia | 30909 | — |
| University Retina and Macula Associates, PC | Oak Forest | Illinois | 60452 | — |
| Prairie Retina Center | Springfield | Illinois | 62704 | — |
| Retina Specialists | Baltimore | Maryland | 21204 | — |
| Tufts Medical Center | Boston | Massachusetts | 02111 | — |
| Associated Retinal Consultants | Grand Rapids | Michigan | 49546 | — |
| Vitreo-Retinal Associates | Grand Rapids | Michigan | 49546 | — |
| Retina Consultants of Nevada | Las Vegas | Nevada | 89144 | — |
| Envision Ocular, LLC | Bloomfield | New Jersey | 07003 | — |
| Long Is. Vitreoretinal Consult | Hauppauge | New York | 11788 | — |
| New York University | New York | New York | 10017 | — |
| Ophthalmic Cons of Long Island | Oceanside | New York | 11572 | — |
| Retina Assoc of Western NY | Rochester | New York | 14620 | — |
| University of Rochester Flaum Eye Institute | Rochester | New York | 14642 | — |
| The Retina Consultants | Slingerlands | New York | 12159 | — |
| Cleveland Clinic Foundation | Cleveland | Ohio | 44195 | — |
| Mid Atlantic Retina - Wills Eye Hospital | Philadelphia | Pennsylvania | 19107 | — |
| Retina Consultants Of Carolina | Greenville | South Carolina | 29605 | — |
| Charleston Neuroscience Inst | Ladson | South Carolina | 29456 | — |
| Palmetto Retina Center | West Columbia | South Carolina | 29169 | — |
| Southeastern Retina Associates Chattanooga | Chattanooga | Tennessee | 37421 | — |
| Southeastern Retina Associates | Knoxville | Tennessee | 37922 | — |
| Tennessee Retina PC | Nashville | Tennessee | 37203 | — |
| Austin Retina Associates | Austin | Texas | 78705 | — |
| Retina Consultants of Texas | Bellaire | Texas | 77401 | — |
| Retina Center of Texas | Southlake | Texas | 76092 | — |
| Univ of Virginia Ophthalmology | Charlottesville | Virginia | 22903 | — |
| Retina Institute of Virginia | Richmond | Virginia | 23235 | — |
| Pacific Northwest Retina | Silverdale | Washington | 98383 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 138 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT03622593, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jul 11, 2025 · Synced Oct 17, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT03622593 live on ClinicalTrials.gov.