ClinicalTrials.gov record
A Study of the Efficacy and Safety of Upadacitinib (ABT-494) in Participants With Moderately to Severely Active Ulcerative Colitis
ClinicalTrials.gov ID: NCT03653026
Public ClinicalTrials.gov record NCT03653026. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Multicenter, Randomized, Double-Blind, Placebo-Controlled Induction Study to Evaluate the Efficacy and Safety of Upadacitinib (ABT-494) in Subjects With Moderately to Severely Active Ulcerative Colitis
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The objective of this study is to evaluate the efficacy and safety of upadacitinib compared to placebo in inducing clinical remission (per Adapted Mayo score) in participants with moderately to severely active ulcerative colitis (UC).
Study identification
- NCT ID
- NCT03653026
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 522 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 16 Years to 75 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Dec 6, 2018 (Actual)
- Primary completion
- Jan 14, 2021 (Actual)
- Completion
- Jan 14, 2021 (Actual)
- Last update posted
- Mar 2, 2022
2018 – 2021
United States locations
- U.S. sites
- 114
- U.S. states
- 33
- U.S. cities
- 93
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| East View Medical Research, LLC /ID# 216933 | Mobile | Alabama | 36606 | — |
| CB Flock Research Corporation /ID# 206094 | Mobile | Alabama | 36608 | — |
| Arizona Arthritis & Rheumatology Research, PLLC /ID# 211030 | Sun City | Arizona | 85306 | — |
| Digestive Disease Consultants, A Division of Arizona Digestive Health, P.C /ID# 211887 | Tempe | Arizona | 85284-2604 | — |
| University of Arizona /ID# 208856 | Tucson | Arizona | 85724 | — |
| Citrus Valley Gastroenterology /ID# 205627 | Covina | California | 91722-3797 | — |
| Care Access Research /ID# 217003 | Huntington Beach | California | 92648-5994 | — |
| Moore UC San Diego Cancer Center /ID# 204919 | La Jolla | California | 92093 | — |
| United Medical Doctors /ID# 207867 | Los Alamitos | California | 90720-3309 | — |
| TLC Clinical Research Inc /ID# 216831 | Los Angeles | California | 90048 | — |
| Gastrointestinal Biosciences Clinical Trials, LLC /ID# 205314 | Los Angeles | California | 90067-2001 | — |
| Facey Medical Foundation /ID# 205301 | Mission Hills | California | 91345 | — |
| United Medical Doctors - Murrieta /ID# 205313 | Murrieta | California | 92563 | — |
| InSite Digestive Health Care - Oxnard /ID# 205628 | Oxnard | California | 93030 | — |
| Inland Empire Clinical Trials, LLC /ID# 216164 | Rialto | California | 92377 | — |
| San Diego Clinical Trials /ID# 212122 | San Diego | California | 92120 | — |
| Medical Assoc Research Grp /ID# 205626 | San Diego | California | 92123 | — |
| Delta Waves, Inc. /ID# 206170 | Colorado Springs | Colorado | 80918 | — |
| Western States Clinical Res /ID# 206091 | Wheat Ridge | Colorado | 80033-2896 | — |
| Western Connecticut Medical Group /ID# 208290 | Danbury | Connecticut | 06810-6000 | — |
| Gastroenterology Center of CT /ID# 208291 | Hamden | Connecticut | 06518 | — |
| Gastro Florida /ID# 206174 | Clearwater | Florida | 33756 | — |
| Universal Axon Clinical Research /ID# 213462 | Doral | Florida | 33166 | — |
| Palmetto Research, LLC /ID# 208293 | Hialeah | Florida | 33016 | — |
| Nature Coast Clinical Research - Inverness /ID# 206087 | Inverness | Florida | 34452-4717 | — |
| Encore Borland-Groover Clinical Research /Id# 208128 | Jacksonville | Florida | 32256 | — |
| Cfagi Llc /Id# 207995 | Maitland | Florida | 32751-6108 | — |
| University of Miami /ID# 215445 | Miami | Florida | 33136 | — |
| Coral Research Clinic /ID# 208292 | Miami | Florida | 33186-4643 | — |
| Advanced Research Institute, Inc /ID# 206077 | New Port Richey | Florida | 34653 | — |
| Endoscopic Research, Inc. /ID# 207360 | Orlando | Florida | 32803 | — |
| Omega Research Consultants /ID# 206066 | Orlando | Florida | 32810 | — |
| Clinical Research Trials of Florida, Inc. /ID# 206068 | Tampa | Florida | 33607 | — |
| University of South Florida /ID# 214495 | Tampa | Florida | 33612 | — |
| AdventHealth Tampa /ID# 207363 | Tampa | Florida | 33613-4680 | — |
| Gastroenterology Associates of Central Georgia, LLC /ID# 216940 | Macon | Georgia | 31201 | — |
| Infinite Clinical Trials /ID# 215343 | Riverdale | Georgia | 30274 | — |
| Atlanta Gastroenterology Spec /ID# 206173 | Suwanee | Georgia | 30024 | — |
| Next Innovative Clinical Research - Chicago /ID# 217324 | Chicago | Illinois | 60605-2168 | — |
| The University of Chicago Medical Center /ID# 206172 | Chicago | Illinois | 60637-1443 | — |
| Carle Foundation Hospital /ID# 207397 | Effingham | Illinois | 62401 | — |
| MediSphere Medical Research Center /ID# 206073 | Evansville | Indiana | 47714-8011 | — |
| Indianapolis Gastroenterology /ID# 206381 | Indianapolis | Indiana | 46237 | — |
| University of Iowa Hospitals and Clinics /ID# 206167 | Iowa City | Iowa | 52242 | — |
| Cotton-O'Neil Clinical Res Ctr /ID# 206175 | Topeka | Kansas | 66606 | — |
| Tri-State Gastroenterology /ID# 206124 | Crestview Hills | Kentucky | 41017 | — |
| Houma Digestive Health Special /ID# 206176 | Houma | Louisiana | 70360 | — |
| Louisana Research Center, LLC /ID# 206064 | Shreveport | Louisiana | 71105-6800 | — |
| Gastro Center of Maryland /ID# 206883 | Columbia | Maryland | 21045 | — |
| University of Michigan Health Systems /ID# 206918 | Ann Arbor | Michigan | 48109 | — |
| Huron Gastroenterology Assoc /ID# 205109 | Ann Arbor | Michigan | 48197 | — |
| Clin Res Inst of Michigan, LLC /ID# 207078 | Chesterfield | Michigan | 48047 | — |
| Revival Research Institute, LLC /ID# 207282 | Southfield | Michigan | 48034-1659 | — |
| Center for Digestive Health /ID# 207080 | Troy | Michigan | 48098-6363 | — |
| Mayo Clinic /ID# 205645 | Rochester | Minnesota | 55905-0001 | — |
| University of Mississippi Medical Center /ID# 213116 | Jackson | Mississippi | 39216-4500 | — |
| Southern Therapy and Advanced Research (STAR) LLC /ID# 206069 | Jackson | Mississippi | 39216 | — |
| Las Vegas Medical Research /ID# 206814 | Las Vegas | Nevada | 89113 | — |
| AGA Clinical Research Associates, LLC /ID# 206880 | Egg Harbor | New Jersey | 08234 | — |
| Atlantic Digestive Health Inst /ID# 208748 | Morristown | New Jersey | 07960 | — |
| Rutgers Robert Wood Johnson /ID# 207382 | New Brunswick | New Jersey | 08901 | — |
| University of New Mexico Department of Internal Medicine /ID# 214397 | Albuquerque | New Mexico | 87131-0001 | — |
| NY Scientific /ID# 206080 | Brooklyn | New York | 11235 | — |
| NYU Langone Long Island Clinical Research Associates /ID# 206079 | Lake Success | New York | 11042 | — |
| DiGiovanna Institute for Medical Education & Research /ID# 206885 | North Massapequa | New York | 11758 | — |
| Premier Medical Group - GI Division /ID# 206097 | Poughkeepsie | New York | 12601 | — |
| Gastro Group of Rochester /ID# 206881 | Rochester | New York | 14618-5703 | — |
| Richmond University Medical Center /ID# 213185 | Staten Island | New York | 10310-1664 | — |
| Advantage Clinical Trials /ID# 206082 | The Bronx | New York | 10468 | — |
| Digestive Health Partners, P.A /ID# 206842 | Asheville | North Carolina | 28801 | — |
| Atrium Health Carolinas Medical Center /ID# 206085 | Charlotte | North Carolina | 28203 | — |
| Charlotte Gastroenterology and Hepatology, PLLC /ID# 206138 | Charlotte | North Carolina | 28207 | — |
| Wake Forest Baptist Medical Center /ID# 206067 | Winston-Salem | North Carolina | 27157-0001 | — |
| Duplicate_Plains Clinical Research Center, LLC /ID# 205111 | Fargo | North Dakota | 58104 | — |
| University of Cincinnati /ID# 205633 | Cincinnati | Ohio | 45267-0585 | — |
| The Ohio State University /ID# 205637 | Columbus | Ohio | 43210 | — |
| Optimed Research, Ltd. /ID# 205638 | Columbus | Ohio | 43235 | — |
| Hometown Urgent Care and Resea /ID# 205630 | Dayton | Ohio | 45424 | — |
| Dayton Gastroenterology, Inc. /ID# 205639 | Englewood | Ohio | 45415 | — |
| Great Lakes Gastroenterology Research LLC /ID# 205631 | Mentor | Ohio | 44060-6211 | — |
| Hightower Clinical /ID# 216336 | Oklahoma City | Oklahoma | 73102 | — |
| Digestive Disease Specialists /ID# 206076 | Oklahoma City | Oklahoma | 73112 | — |
| Options Health Research, LLC /ID# 206707 | Tulsa | Oklahoma | 74104 | — |
| Healthcare Research Consultant /ID# 206706 | Tulsa | Oklahoma | 74135 | — |
| Guthrie Medical Group, PC /ID# 206078 | Sayre | Pennsylvania | 18840 | — |
| Pharmacorp Clinical Trials /ID# 206074 | Charleston | South Carolina | 29412 | — |
| Gastroenterology Associates, P.A. of Greenville /ID# 206098 | Greenville | South Carolina | 29615-3593 | — |
| Gastro One /ID# 206178 | Germantown | Tennessee | 38138 | — |
| East Tennessee Research Institute /ID# 206169 | Johnson City | Tennessee | 37604 | — |
| Quality Medical Research /ID# 206088 | Nashville | Tennessee | 37211 | — |
| Vanderbilt University Medical Center /ID# 210405 | Nashville | Tennessee | 37232-0011 | — |
| TX Clinical Research Institute /ID# 206718 | Arlington | Texas | 76012 | — |
| Inquest Clinical Research /ID# 206132 | Baytown | Texas | 77521 | — |
| Texas Digestive Disease Consultants /ID# 209805 | Cedar Park | Texas | 78613-5028 | — |
| Texas Digestive Disease Consultants /ID# 209948 | Cedar Park | Texas | 78613-5028 | — |
| Baylor Scott & White Center for Inflammatory Bowel Diseases /ID# 207484 | Dallas | Texas | 75246 | — |
| DHAT Research Institute /ID# 206716 | Garland | Texas | 75044-2208 | — |
| Vilo Research Group Inc /ID# 212625 | Houston | Texas | 77017-2337 | — |
| Baylor College of Medicine - Baylor Medical Center /ID# 206717 | Houston | Texas | 77030-3411 | — |
| Centex Studies, Inc. - Houston /ID# 206168 | Houston | Texas | 77058 | — |
| GI Specialists of Houston /ID# 206090 | Houston | Texas | 77070-4347 | — |
| Caprock Gastro Research /ID# 215115 | Lubbock | Texas | 79424-3017 | — |
| Clinical Associates in Research Therapeutics of America, LLC /ID# 206710 | San Antonio | Texas | 78212 | — |
| Southern Star Research Institute, LLC /ID# 205379 | San Antonio | Texas | 78229-5390 | — |
| Baylor Scott & White Center for Diagnostic Medicine /ID# 206096 | Temple | Texas | 76508 | — |
| Duplicate_Tyler Research Institue /ID# 206075 | Tyler | Texas | 75701 | — |
| Gastro Health & Nutrition - Victoria /ID# 205378 | Victoria | Texas | 77904 | — |
| Advanced Research Institute /ID# 206133 | Ogden | Utah | 84403 | — |
| Ctr for Gastrointestinal Healt /ID# 208475 | Franklin | Virginia | 23851 | — |
| Washington Gastroenterology Associates /ID# 206177 | Bellevue | Washington | 98004 | — |
| Virginia Mason - Seattle Orthapedics /ID# 206070 | Seattle | Washington | 98101 | — |
| The Vancouver Clinic, INC. PS /ID# 204973 | Vancouver | Washington | 98664 | — |
| Wisconsin Center for Advanced Research, a division of GI Associates, LLC /ID# 206917 | Milwaukee | Wisconsin | 53215 | — |
| Froedtert Memorial Lutheran Hospital /ID# 206945 | Milwaukee | Wisconsin | 53226-3522 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 265 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT03653026, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Mar 2, 2022 · Synced Oct 27, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT03653026 live on ClinicalTrials.gov.