KRT-232 Versus Best Available Therapy for the Treatment of Subjects With Myelofibrosis Who Are Relapsed or Refractory to JAK Inhibitor Treatment

ClinicalTrials.gov ID: NCT03662126

Public ClinicalTrials.gov record NCT03662126. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced May 19, 2026, 6:21 AM EDT

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Official title

A Phase 2/3 Randomized, Controlled, Open-Label Study of KRT 232 in Subjects With Primary Myelofibrosis (PMF), Post Polycythemia Vera MF (Post-PV-MF), Or Post Essential Thrombocythemia MF (Post-ET-MF) Who Are Relapsed or Refractory to Janus Kinase (JAK) Inhibitor Treatment

Study identification

NCT ID: NCT03662126
Recruitment status: Not listed
Study type: Interventional
Phase: Phase 2, Phase 3
Lead sponsor: Kartos Therapeutics, Inc.; Industry
Enrollment: 385 participants

Conditions and interventions

Conditions

Interventions

Best Available Therapy (BAT) Drug
KRT-232 Drug

Drug

Eligibility (public fields only)

Age range: 18 Years and older
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Jan 14, 2019
Primary completion: Dec 30, 2023
Completion: Dec 30, 2025
Last update posted: Apr 27, 2023

2019 – 2025

United States locations

U.S. sites: 19
U.S. states: 13
U.S. cities: 17

Facility	City	State	ZIP	Site status
The Kirklin Clinic of UAB Hospital	Birmingham	Alabama	35294	Active, not recruiting
University of Southern California Norris Comprehensive Cancer Center	Los Angeles	California	90033	Active, not recruiting
Stanford Cancer Center - Palo Alto	Stanford	California	94305	Active, not recruiting
Innovative Clinical Research Institute	Whittier	California	90603	Completed
University Cancer Institute	Boynton Beach	Florida	33426	Withdrawn
Northwestern University Feinberg School of Medicine	Chicago	Illinois	60611	Completed
University of Illinois at Chicago	Chicago	Illinois	60612	Recruiting
Dana-Farber Cancer Institute	Boston	Massachusetts	02215	Withdrawn
Washington University School of Medicine	St Louis	Missouri	63110	Recruiting
Brookdale University Hospital and Medical Center	Brooklyn	New York	11212	Recruiting
New York Presbyterian/Weill Cornell Medical Center	New York	New York	10021	Withdrawn
Mt. Sinai	New York	New York	10029	Recruiting
Gabrail Cancer Center	Canton	Ohio	44718	Recruiting
The Ohio State University Comprehensive Cancer Center	Columbus	Ohio	43210	Completed
Oregon Health and Science University	Portland	Oregon	97239	Completed
Avera Cancer Institute	Sioux Falls	South Dakota	57105	Recruiting
Vanderbilt University Medical Center	Nashville	Tennessee	37203	Recruiting
The University of Texas MD Anderson Cancer Center	Houston	Texas	77030	Recruiting
Medical College of Wisconsin - Froedtert Hospital	Milwaukee	Wisconsin	53226	Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 172 non-U.S. sites.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT03662126, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted Apr 27, 2023 · Synced May 19, 2026

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The complete protocol, eligibility criteria, and contact information for NCT03662126 live on ClinicalTrials.gov.

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