A Study to Investigate the Safety and Efficacy of ABBV-105 Alone or in Combination With Upadacitinib (ABBV-599 Combination) in Participants With Active Rheumatoid Arthritis
Public ClinicalTrials.gov record NCT03682705. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
Rheumatoid Arthritis: A Phase 2 Study to Investigate the Safety and Efficacy of ABBV-105 Given Alone or in Combination With Upadacitinib (ABBV-599 Combination) With a Background of Conventional Synthetic DMARDs in Subjects With Active Rheumatoid Arthritis With Inadequate Response or Intolerance to Biologic DMARDs
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This was a phase 2 study to evaluate the safety and efficacy of elsubrutinib (ELS) and ABBV-599 (ELS plus upadacitinib \[UPA\]) vs placebo on a background of conventional synthetic disease-modifying anti-rheumatic drugs (csDMARDs) for the treatment of signs and symptoms of rheumatoid arthritis (RA) at 12 weeks in biological disease-modifying anti-rheumatic drugs (bDMARD)-inadequate response (bDMARD-IR) or bDMARD-intolerant participants with moderately to severely active RA and to define optimal dose for further development.
Study identification
- NCT ID
- NCT03682705
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 242 participants
Conditions and interventions
Conditions
Interventions
- Elsubrutinib Drug
- Upadacitinib Drug
- Placebo for elsubrutinib Drug
- Placebo for upadacitinib Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Oct 8, 2018 (Actual)
- Primary completion
- Mar 26, 2020 (Actual)
- Completion
- Mar 26, 2020 (Actual)
- Last update posted
- May 3, 2021
2018 – 2020
United States locations
- U.S. sites
- 78
- U.S. states
- 27
- U.S. cities
- 69
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Rheum Assoc of North Alabama /ID# 167382 | Huntsville | Alabama | 35801 | — |
| AZ Arthritis & Rheum Research /ID# 167446 | Mesa | Arizona | 85210 | — |
| SunValley Arthritis Center, Lt /ID# 213073 | Peoria | Arizona | 85381 | — |
| AZ Arthritis and Rheum Researc /ID# 167448 | Phoenix | Arizona | 85032 | — |
| St. Joseph Heritage Healthcare /ID# 167379 | Fullerton | California | 92835 | — |
| Purushotham, Akther & Roshan K /ID# 168121 | La Mesa | California | 91942 | — |
| Valerius Medical Group /ID# 168123 | Los Alamitos | California | 90720 | — |
| Sierra Rheumatology /ID# 167976 | Roseville | California | 95661 | — |
| Rheumatology Center of San Diego /ID# 170690 | San Diego | California | 92128-2549 | — |
| Iraj Sabahi Research, Inc /ID# 201923 | Turlock | California | 95382-2007 | — |
| Inland Rheum Clin Trials Inc. /ID# 167459 | Upland | California | 91786 | — |
| Medvin Clinical Research /ID# 205731 | Whittier | California | 90606 | — |
| Rheumatology Consultants of De /ID# 208238 | Lewes | Delaware | 19958 | — |
| Bay Area Arthritis and Osteo /ID# 208111 | Brandon | Florida | 33511 | — |
| Clinical Res of West FL, Inc. /ID# 167462 | Clearwater | Florida | 33765 | — |
| Omega Research Maitland, LLC /ID# 167376 | DeBary | Florida | 32713-2260 | — |
| Riverside Clinical Research /ID# 167982 | Edgewater | Florida | 32132 | — |
| Lakes Research, LLC /ID# 170660 | Miami | Florida | 33014 | — |
| Kendall South Medical Center, Inc. /ID# 206857 | Miami | Florida | 33185-5948 | — |
| Medallion Clinical Research Institute, LLC /ID# 201710 | Naples | Florida | 34102 | — |
| Rheum Assoc of Central FL /ID# 170858 | Orlando | Florida | 32806 | — |
| HMD Research LLC /ID# 208381 | Orlando | Florida | 32819 | — |
| International Medical Research - Ormond /ID# 170864 | Ormond Beach | Florida | 32174 | — |
| Millennium Research /ID# 167453 | Ormond Beach | Florida | 32174 | — |
| Arthritis Center, Inc. /ID# 170695 | Palm Harbor | Florida | 34684 | — |
| Integral Rheumatology & Immunology Specialists /ID# 206724 | Plantation | Florida | 33324 | — |
| BayCare Medical Group /ID# 170860 | St. Petersburg | Florida | 33705 | — |
| St. Anthony Comprehensive Rese /ID# 170668 | St. Petersburg | Florida | 33705 | — |
| Clinical Research of West Florida, Inc /ID# 169099 | Tampa | Florida | 33606-1246 | — |
| ForCare Clinical Research /ID# 206280 | Tampa | Florida | 33613-1244 | — |
| Florida Medical Clinic /ID# 206279 | Zephyrhills | Florida | 33542 | — |
| Institute of Arthritis Researc /ID# 170694 | Idaho Falls | Idaho | 83404 | — |
| Great Lakes Clinical Trials /ID# 167471 | Chicago | Illinois | 60640 | — |
| Clinical Investigation Specialists - Skokie /ID# 167468 | Skokie | Illinois | 60076 | — |
| Deerbrook Medical Associates /ID# 207098 | Vernon Hills | Illinois | 60061 | — |
| PRN of Kansas /ID# 167985 | Wichita | Kansas | 67205 | — |
| The Arthritis & Diabetes Clinic, Inc. /ID# 170682 | Monroe | Louisiana | 71203 | — |
| Mansfield Health Center /ID# 167372 | Mansfield | Massachusetts | 02048 | — |
| Advanced Clinical Care /ID# 167367 | Worcester | Massachusetts | 01605 | — |
| June DO, PC /ID# 170670 | Lansing | Michigan | 48910 | — |
| Beals Instititute /ID# 170658 | Lansing | Michigan | 48917 | — |
| Arthritis Associates /ID# 209075 | Hattiesburg | Mississippi | 39402 | — |
| North Mississippi Med Clinics /ID# 167377 | Tupelo | Mississippi | 38801 | — |
| Clayton Medical Associates dba Saint Louis Rheumatology /ID# 170650 | St Louis | Missouri | 63119-3845 | — |
| Physician Research Collaboration, LLC /ID# 200480 | Lincoln | Nebraska | 68516 | — |
| Dhmc /Id# 167476 | Lebanon | New Hampshire | 03756 | — |
| Ocean Rheumatology /ID# 170673 | Toms River | New Jersey | 08755 | — |
| Arthritis and Osteo Assoc /ID# 167443 | Las Cruces | New Mexico | 88011 | — |
| DJL Clinical Research, PLLC /ID# 167374 | Charlotte | North Carolina | 28210-8508 | — |
| EmergeOrtho, P.A. /ID# 209154 | Durham | North Carolina | 27704 | — |
| Cape Fear Arthritis Care /ID# 167413 | Leland | North Carolina | 28451 | — |
| New Horizons Clinical Research /ID# 170862 | Blue Ash | Ohio | 45242-3763 | — |
| Marietta Memorial Hospital /ID# 210968 | Marietta | Ohio | 45750-1635 | — |
| STAT Research, Inc. /ID# 200485 | Vandalia | Ohio | 45377-9464 | — |
| Health Research of Oklahoma /ID# 167370 | Oklahoma City | Oklahoma | 73103-2400 | — |
| Clinical Research Ctr Reading /ID# 170708 | Wyomissing | Pennsylvania | 19610 | — |
| West Tennessee Research Inst /ID# 167366 | Jackson | Tennessee | 38305 | — |
| Nashville Arthritis and Rheumatology /ID# 206699 | Nashville | Tennessee | 37203 | — |
| Amarillo Ctr for Clin Research /ID# 200484 | Amarillo | Texas | 79124 | — |
| Tekton Research, Inc. /ID# 167475 | Austin | Texas | 78745 | — |
| Trinity Universal Res Assoc /ID# 209252 | Carrollton | Texas | 75007 | — |
| Arth and Osteo Clin Brazo Valley /ID# 209401 | College Station | Texas | 77845 | — |
| Metroplex Clinical Research /ID# 167458 | Dallas | Texas | 75231 | — |
| Rheumatic Disease Clin Res Ctr /ID# 167474 | Houston | Texas | 77004 | — |
| Rheumatology Clinic of Houston /ID# 203689 | Houston | Texas | 77065 | — |
| Accurate Clinical Research /ID# 207059 | Houston | Texas | 77089 | — |
| West Texas Clinical Research /ID# 205732 | Lubbock | Texas | 79410-1198 | — |
| SW Rheumatology Res. LLC /ID# 167383 | Mesquite | Texas | 75150 | — |
| Trinity Universal Research Association /ID# 209253 | Plano | Texas | 75024-5283 | — |
| Sun Research Institute /ID# 170667 | San Antonio | Texas | 78215 | — |
| Accurate Clinical Management /ID# 200481 | San Antonio | Texas | 78229 | — |
| DM Clinical Research /ID# 167444 | Tomball | Texas | 77375 | — |
| Arthritis & Osteoporosis Clinic /ID# 167407 | Waco | Texas | 76710 | — |
| Tidewater Physicians Medical Center /ID# 210884 | Newport News | Virginia | 23606-4434 | — |
| Western Washington Arthritis C /ID# 205821 | Bothell | Washington | 98021 | — |
| Arthritis Northwest, PLLC /ID# 200479 | Spokane | Washington | 99204 | — |
| Rheumatology and Pulmonary cli /ID# 170863 | Beckley | West Virginia | 25801 | — |
| Aurora Rheumatology and Immunotherapy Center /ID# 167385 | Franklin | Wisconsin | 53132 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 37 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT03682705, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted May 3, 2021 · Synced Oct 21, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT03682705 live on ClinicalTrials.gov.