ClinicalTrials.gov record
A Study to Investigate the Safety and Efficacy of ABBV-105 Alone or in Combination With Upadacitinib (ABBV-599 Combination) in Participants With Active Rheumatoid Arthritis
ClinicalTrials.gov ID: NCT03682705
Public ClinicalTrials.gov record NCT03682705. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
ClinicalTrials.gov public records Last synced May 12, 2026, 4:00 AM EDT
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
Rheumatoid Arthritis: A Phase 2 Study to Investigate the Safety and Efficacy of ABBV-105 Given Alone or in Combination With Upadacitinib (ABBV-599 Combination) With a Background of Conventional Synthetic DMARDs in Subjects With Active Rheumatoid Arthritis With Inadequate Response or Intolerance to Biologic DMARDs
Study identification
- NCT ID
- NCT03682705
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2
- Lead sponsor
- AbbVie
- Industry
- Enrollment
- 242 participants
Conditions and interventions
Conditions
Interventions
- Elsubrutinib Drug
- Placebo for elsubrutinib Drug
- Placebo for upadacitinib Drug
- Upadacitinib Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Oct 7, 2018
- Primary completion
- Mar 25, 2020
- Completion
- Mar 25, 2020
- Last update posted
- May 2, 2021
2018 – 2020
United States locations
- U.S. sites
- 78
- U.S. states
- 27
- U.S. cities
- 69
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Rheum Assoc of North Alabama /ID# 167382 | Huntsville | Alabama | 35801 | — |
| AZ Arthritis & Rheum Research /ID# 167446 | Mesa | Arizona | 85210 | — |
| SunValley Arthritis Center, Lt /ID# 213073 | Peoria | Arizona | 85381 | — |
| AZ Arthritis and Rheum Researc /ID# 167448 | Phoenix | Arizona | 85032 | — |
| St. Joseph Heritage Healthcare /ID# 167379 | Fullerton | California | 92835 | — |
| Purushotham, Akther & Roshan K /ID# 168121 | La Mesa | California | 91942 | — |
| Valerius Medical Group /ID# 168123 | Los Alamitos | California | 90720 | — |
| Sierra Rheumatology /ID# 167976 | Roseville | California | 95661 | — |
| Rheumatology Center of San Diego /ID# 170690 | San Diego | California | 92128-2549 | — |
| Iraj Sabahi Research, Inc /ID# 201923 | Turlock | California | 95382-2007 | — |
| Inland Rheum Clin Trials Inc. /ID# 167459 | Upland | California | 91786 | — |
| Medvin Clinical Research /ID# 205731 | Whittier | California | 90606 | — |
| Rheumatology Consultants of De /ID# 208238 | Lewes | Delaware | 19958 | — |
| Bay Area Arthritis and Osteo /ID# 208111 | Brandon | Florida | 33511 | — |
| Clinical Res of West FL, Inc. /ID# 167462 | Clearwater | Florida | 33765 | — |
| Omega Research Maitland, LLC /ID# 167376 | DeBary | Florida | 32713-2260 | — |
| Riverside Clinical Research /ID# 167982 | Edgewater | Florida | 32132 | — |
| Lakes Research, LLC /ID# 170660 | Miami | Florida | 33014 | — |
| Kendall South Medical Center, Inc. /ID# 206857 | Miami | Florida | 33185-5948 | — |
| Medallion Clinical Research Institute, LLC /ID# 201710 | Naples | Florida | 34102 | — |
| Rheum Assoc of Central FL /ID# 170858 | Orlando | Florida | 32806 | — |
| HMD Research LLC /ID# 208381 | Orlando | Florida | 32819 | — |
| International Medical Research - Ormond /ID# 170864 | Ormond Beach | Florida | 32174 | — |
| Millennium Research /ID# 167453 | Ormond Beach | Florida | 32174 | — |
| Arthritis Center, Inc. /ID# 170695 | Palm Harbor | Florida | 34684 | — |
| Integral Rheumatology & Immunology Specialists /ID# 206724 | Plantation | Florida | 33324 | — |
| BayCare Medical Group /ID# 170860 | St. Petersburg | Florida | 33705 | — |
| St. Anthony Comprehensive Rese /ID# 170668 | St. Petersburg | Florida | 33705 | — |
| Clinical Research of West Florida, Inc /ID# 169099 | Tampa | Florida | 33606-1246 | — |
| ForCare Clinical Research /ID# 206280 | Tampa | Florida | 33613-1244 | — |
| Florida Medical Clinic /ID# 206279 | Zephyrhills | Florida | 33542 | — |
| Institute of Arthritis Researc /ID# 170694 | Idaho Falls | Idaho | 83404 | — |
| Great Lakes Clinical Trials /ID# 167471 | Chicago | Illinois | 60640 | — |
| Clinical Investigation Specialists - Skokie /ID# 167468 | Skokie | Illinois | 60076 | — |
| Deerbrook Medical Associates /ID# 207098 | Vernon Hills | Illinois | 60061 | — |
| PRN of Kansas /ID# 167985 | Wichita | Kansas | 67205 | — |
| The Arthritis & Diabetes Clinic, Inc. /ID# 170682 | Monroe | Louisiana | 71203 | — |
| Mansfield Health Center /ID# 167372 | Mansfield | Massachusetts | 02048 | — |
| Advanced Clinical Care /ID# 167367 | Worcester | Massachusetts | 01605 | — |
| June DO, PC /ID# 170670 | Lansing | Michigan | 48910 | — |
| Beals Instititute /ID# 170658 | Lansing | Michigan | 48917 | — |
| Arthritis Associates /ID# 209075 | Hattiesburg | Mississippi | 39402 | — |
| North Mississippi Med Clinics /ID# 167377 | Tupelo | Mississippi | 38801 | — |
| Clayton Medical Associates dba Saint Louis Rheumatology /ID# 170650 | St Louis | Missouri | 63119-3845 | — |
| Physician Research Collaboration, LLC /ID# 200480 | Lincoln | Nebraska | 68516 | — |
| Dhmc /Id# 167476 | Lebanon | New Hampshire | 03756 | — |
| Ocean Rheumatology /ID# 170673 | Toms River | New Jersey | 08755 | — |
| Arthritis and Osteo Assoc /ID# 167443 | Las Cruces | New Mexico | 88011 | — |
| DJL Clinical Research, PLLC /ID# 167374 | Charlotte | North Carolina | 28210-8508 | — |
| EmergeOrtho, P.A. /ID# 209154 | Durham | North Carolina | 27704 | — |
| Cape Fear Arthritis Care /ID# 167413 | Leland | North Carolina | 28451 | — |
| New Horizons Clinical Research /ID# 170862 | Blue Ash | Ohio | 45242-3763 | — |
| Marietta Memorial Hospital /ID# 210968 | Marietta | Ohio | 45750-1635 | — |
| STAT Research, Inc. /ID# 200485 | Vandalia | Ohio | 45377-9464 | — |
| Health Research of Oklahoma /ID# 167370 | Oklahoma City | Oklahoma | 73103-2400 | — |
| Clinical Research Ctr Reading /ID# 170708 | Wyomissing | Pennsylvania | 19610 | — |
| West Tennessee Research Inst /ID# 167366 | Jackson | Tennessee | 38305 | — |
| Nashville Arthritis and Rheumatology /ID# 206699 | Nashville | Tennessee | 37203 | — |
| Amarillo Ctr for Clin Research /ID# 200484 | Amarillo | Texas | 79124 | — |
| Tekton Research, Inc. /ID# 167475 | Austin | Texas | 78745 | — |
| Trinity Universal Res Assoc /ID# 209252 | Carrollton | Texas | 75007 | — |
| Arth and Osteo Clin Brazo Valley /ID# 209401 | College Station | Texas | 77845 | — |
| Metroplex Clinical Research /ID# 167458 | Dallas | Texas | 75231 | — |
| Rheumatic Disease Clin Res Ctr /ID# 167474 | Houston | Texas | 77004 | — |
| Rheumatology Clinic of Houston /ID# 203689 | Houston | Texas | 77065 | — |
| Accurate Clinical Research /ID# 207059 | Houston | Texas | 77089 | — |
| West Texas Clinical Research /ID# 205732 | Lubbock | Texas | 79410-1198 | — |
| SW Rheumatology Res. LLC /ID# 167383 | Mesquite | Texas | 75150 | — |
| Trinity Universal Research Association /ID# 209253 | Plano | Texas | 75024-5283 | — |
| Sun Research Institute /ID# 170667 | San Antonio | Texas | 78215 | — |
| Accurate Clinical Management /ID# 200481 | San Antonio | Texas | 78229 | — |
| DM Clinical Research /ID# 167444 | Tomball | Texas | 77375 | — |
| Arthritis & Osteoporosis Clinic /ID# 167407 | Waco | Texas | 76710 | — |
| Tidewater Physicians Medical Center /ID# 210884 | Newport News | Virginia | 23606-4434 | — |
| Western Washington Arthritis C /ID# 205821 | Bothell | Washington | 98021 | — |
| Arthritis Northwest, PLLC /ID# 200479 | Spokane | Washington | 99204 | — |
| Rheumatology and Pulmonary cli /ID# 170863 | Beckley | West Virginia | 25801 | — |
| Aurora Rheumatology and Immunotherapy Center /ID# 167385 | Franklin | Wisconsin | 53132 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 37 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT03682705, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted May 2, 2021 · Synced May 12, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT03682705 live on ClinicalTrials.gov.