Extension Study for the Port Delivery System With Ranibizumab (Portal)

ClinicalTrials.gov ID: NCT03683251

Public ClinicalTrials.gov record NCT03683251. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced Apr 29, 2026, 9:02 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Multicenter, Open-Label Extension Study to Evaluate the Long-Term Safety and Tolerability of the Port Delivery System With Ranibizumab in Patients With Neovascular Age-Related Macular Degeneration (Portal)

Study identification

NCT ID: NCT03683251
Recruitment status: Recruiting
Study type: Interventional
Phase: Phase 3
Lead sponsor: Hoffmann-La Roche; Industry
Enrollment: 1,000 participants

Conditions and interventions

Conditions

Neovascular Age-Related Macular Degeneration

Interventions

PDS Implant with Ranibizumab 100 mg/mL Drug

Drug

Eligibility (public fields only)

Age range: 50 Years and older
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Sep 19, 2018
Primary completion: Oct 30, 2029
Completion: Oct 30, 2029
Last update posted: Apr 26, 2026

2018 – 2029

United States locations

U.S. sites: 81
U.S. states: 31
U.S. cities: 72

Facility	City	State	ZIP	Site status
Retinal Research Institute, LLC	Phoenix	Arizona	85014	Completed
Arizona Retina and Vitreous Consultants	Phoenix	Arizona	85016	Completed
Barnet Dulaney Perkins Eye Center	Phoenix	Arizona	85016	Active, not recruiting
Associated Retina Consultants	Phoenix	Arizona	85020	Completed
Retinal Consultants of Arizona	Phoenix	Arizona	85053	Completed
California Retina Consultants	Bakersfield	California	93309	Completed
Retina-Vitreous Associates Medical Group	Beverly Hills	California	90211	Completed
The Retina Partners	Encino	California	91436	Active, not recruiting
Jacobs Retina center at the Shiley eye Institute UCSD	La Jolla	California	92037	Completed
Jules Stein Eye Institute/ UCLA	Los Angeles	California	90095-7000	Completed
N CA Retina Vitreous Assoc	Mountain View	California	94040	Completed
Retina Consultants, San Diego	Poway	California	92064	Completed
Retinal Consultants Med Group	Sacramento	California	95841	Completed
West Coast Retina Medical Group	San Francisco	California	94109	Completed
UCSF	San Francisco	California	94158	Completed
Orange County Retina Med Group	Santa Ana	California	92705	Completed
California Retina Consultants	Santa Barbara	California	93103	Completed
Southwest Retina Consultants	Durango	Colorado	81303	Completed
Eye Center of Northern CO	Fort Collins	Colorado	80528	Completed
Colorado Retina Associates, PC	Lakewood	Colorado	80228	Completed
Retina Group of New England	Waterford	Connecticut	06385	Completed
Florida Eye Microsurgical Inst	Boynton Beach	Florida	33426	Completed
National Ophthalmic Research Institute	Fort Myers	Florida	33912	Completed
Florida Eye Associates	Melbourne	Florida	32901	Completed
Retina Care Specialists	Palm Beach Gardens	Florida	33410	Completed
Retina Specialty Institute	Pensacola	Florida	32503	Completed
Fort Lauderdale Eye Institute	Plantation	Florida	33324	Completed
Retina Vitreous Assoc of FL	St. Petersburg	Florida	33711	Active, not recruiting
Southern Vitreoretinal Assoc	Tallahassee	Florida	32308	Active, not recruiting
Retina Associates of Florida, LLC	Tampa	Florida	33609	Completed
Southeast Retina Center	Augusta	Georgia	30909	Completed
Georgia Retina PC	Marietta	Georgia	30060	Withdrawn
Illinois Retina Associates	Joliet	Illinois	60435	Completed
University Retina and Macula Associates, PC	Oak Forest	Illinois	60452	Completed
Wolfe Eye Clinic	West Des Moines	Iowa	50266	Completed
Retina Associates	Lenexa	Kansas	66215	Completed
Retina Associates of Kentucky	Lexington	Kentucky	40509	Completed
Paducah Retinal Center	Paducah	Kentucky	42001	Withdrawn
Maine Eye Center	Portland	Maine	04101	Completed
The Retina Care Center	Baltimore	Maryland	21209	Completed
Johns Hopkins Med	Baltimore	Maryland	21287	Active, not recruiting
Retina Group of Washington	Chevy Chase	Maryland	20815	Completed
Retina Specialists	Towson	Maryland	21204	Completed
Ophthalmic Consultants of Boston	Boston	Massachusetts	02114	Completed
Foundation for Vision Research	Grand Rapids	Michigan	49546	Completed
Associated Retinal Consultants	Royal Oak	Michigan	48073	Completed
VitreoRetinal Surgery, PLLC.	Minneapolis	Minnesota	55435	Completed
Midwest Vision Research Foundation	Chesterfield	Missouri	63017	Completed
The Retina Institute - Chesterfield	St Louis	Missouri	63128	Completed
Sierra Eye Associates	Reno	Nevada	89502	Completed
Envision Ocular, LLC	Bloomfield	New Jersey	07003	Completed
Retina Associates of NJ	Teaneck	New Jersey	07666	Completed
University of New Mexico	Albuquerque	New Mexico	87131	Completed
Long Is. Vitreoretinal Consult	Great Neck	New York	11021	Completed
Retina Assoc of Western NY	Rochester	New York	14620	Completed
Ophthalmic Consultants of Long Island	Rockville Centre	New York	11570	Completed
Retina Vit Surgeons/Central NY	Syracuse	New York	13224	Completed
Char Eye Ear &Throat Assoc	Charlotte	North Carolina	28210	Completed
Cincinnati Eye Institute	Cincinnati	Ohio	45242	Completed
The Cleveland Clinic Foundation	Cleveland	Ohio	44195	Completed
OSU Eye Physicians & Surgeons	Columbus	Ohio	43212	Active, not recruiting
Retina Vitreous Center	Edmond	Oklahoma	73013	Completed
Retina Northwest	Portland	Oregon	97221	Completed
Oregon HSU	Portland	Oregon	97239	Completed
Mid Atlantic Retina - Wills Eye Hospital	Philadelphia	Pennsylvania	19107	Completed
Palmetto Retina Center	Florence	South Carolina	29501	Completed
Palmetto Retina Center, LLC	West Columbia	South Carolina	29169	Completed
Charles Retina Institute	Germantown	Tennessee	38138	Completed
Tennessee Retina PC	Nashville	Tennessee	37203	Active, not recruiting
Texas Retina Associates	Arlington	Texas	76012	Completed
Austin Retina Associates	Austin	Texas	78705	Completed
Austin Clinical Research LLC	Austin	Texas	78750	Active, not recruiting
Retina Consultants of Texas	Bellaire	Texas	77401	Completed
Texas Retina Associates	Fort Worth	Texas	76104	Completed
Med Center Ophthalmology Assoc	San Antonio	Texas	78240	Completed
Retina Consultants of Texas	The Woodlands	Texas	77384	Completed
Retina Associates of Utah, PLLC	Salt Lake City	Utah	84107	Completed
Rocky Mountain Retina	Salt Lake City	Utah	84107	Completed
Wagner Kapoor Institute	Virginia Beach	Virginia	23454	Completed
Pacific Northwest Retina	Silverdale	Washington	98383	Completed
Spokane Eye Clinical Research	Spokane	Washington	99204	Completed

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 84 non-U.S. sites.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT03683251, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted Apr 26, 2026 · Synced Apr 29, 2026

Open the official record

The complete protocol, eligibility criteria, and contact information for NCT03683251 live on ClinicalTrials.gov.

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