Edwards PASCAL CLASP IID/IIF Pivotal Clinical Trial
Public ClinicalTrials.gov record NCT03706833. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
Edwards PASCAL TrAnScatheter Valve RePair System Pivotal Clinical Trial (CLASP IID/IIF): A Prospective, Multicenter, Randomized, Controlled Pivotal Trial to Evaluate the Safety and Effectiveness of Transcatheter Mitral Valve Repair With the Edwards PASCAL Transcatheter Valve Repair System Compared to Abbott MitraClip in Patients With Mitral Regurgitation
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
To establish the safety and effectiveness of the Edwards PASCAL Transcatheter Valve Repair System in patients with degenerative mitral regurgitation (DMR) who have been determined to be at prohibitive risk for mitral valve surgery by the Heart Team, and in patients with functional mitral regurgitation (FMR) on guideline directed medical therapy (GDMT)
Study identification
- NCT ID
- NCT03706833
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Not applicable
- Enrollment
- 1,247 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Nov 30, 2018 (Actual)
- Primary completion
- Jun 30, 2026 (Estimated)
- Completion
- Jun 30, 2031 (Estimated)
- Last update posted
- Jul 8, 2026
2018 – 2031
United States locations
- U.S. sites
- 63
- U.S. states
- 25
- U.S. cities
- 53
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Banner University Medical Center | Phoenix | Arizona | 85006 | — |
| TMC Healthcare | Tucson | Arizona | 85712 | — |
| Scripps Memorial Hospital La Jolla | La Jolla | California | 92071 | — |
| Cedars Sinai Medical Center | Los Angeles | California | 90048 | — |
| UC Irvine | Orange | California | 92868 | — |
| Sutter Medical Center-Sacramento | Sacramento | California | 95618 | — |
| Kaiser Permanente San Francisco | San Francisco | California | 94118 | — |
| University of California, San Francisco | San Francisco | California | 94143 | — |
| Stanford University | Stanford | California | 94305 | — |
| Los Robles Hospital and Medical Center | Thousand Oaks | California | 91360 | — |
| Medical Center of the Rockies | Loveland | Colorado | 80538 | — |
| Medstar Washington Hospital Center | Washington D.C. | District of Columbia | 20010 | — |
| The Cardiac and Vascular Institute Research Foundation | Gainesville | Florida | 32605 | — |
| Mount Sinai | Miami Beach | Florida | 33140 | — |
| NCH Rooney Heart Institute | Naples | Florida | 34102 | — |
| AdventHealth Orlando | Orlando | Florida | 32803 | — |
| Piedmont Healthcare | Atlanta | Georgia | 30309 | — |
| Emory University Hospital and Emory University Hospital Midtown | Atlanta | Georgia | 30322 | — |
| Northwestern University | Chicago | Illinois | 60611 | — |
| St. Vincent Heart Center | Carmel | Indiana | 46290 | — |
| University of Iowa Hospitals & Clinics | Iowa City | Iowa | 52242 | — |
| Massachusetts General Hospital | Boston | Massachusetts | 02114 | — |
| Brigham and Woman's Hospital | Boston | Massachusetts | 02115 | — |
| Beth Israel Deaconess Medical Center | Boston | Massachusetts | 02215 | — |
| University of Michigan | Ann Arbor | Michigan | 48109 | — |
| Henry Ford Hospital | Detroit | Michigan | 48202 | — |
| Mayo Clinic | Rochester | Minnesota | 55905 | — |
| St.Luke's Hospital of Kansas City | Kansas City | Missouri | 64111 | — |
| Washington University/Barnes Jewish Hospital | St Louis | Missouri | 63110 | — |
| Morristown Medical Center | Morristown | New Jersey | 07960 | — |
| Rutgers-RWJMS | New Brunswick | New Jersey | 08901 | — |
| Albany Medical College | Albany | New York | 12208 | — |
| State University of New York at Buffalo | Buffalo | New York | 14203 | — |
| NYU Langone Hospital - Long Island | Mineola | New York | 11501 | — |
| NYU Langone Health | New York | New York | 10016 | — |
| Columbia University Medical Center/New York Presbyterian Hospital | New York | New York | 10032 | — |
| Lenox Hill Hospital and North Shore University | New York | New York | 10075 | — |
| Rochester General Hospital | Rochester | New York | 14621 | — |
| Montefiore Medical Center | The Bronx | New York | 10467 | — |
| The Christ Hospital | Cincinnati | Ohio | 45219-2906 | — |
| Cleveland Clinic Foundation | Cleveland | Ohio | 44195 | — |
| Oklahoma Cardiovascular | Oklahoma City | Oklahoma | 73120 | — |
| Oklahoma Heart Institute | Tulsa | Oklahoma | 74104 | — |
| Oregon Health & Science University | Portland | Oregon | 97239 | — |
| Hospital of the University of Pennsylvania/Penn Presbyterian Medical Center | Philadelphia | Pennsylvania | 19104 | — |
| Allegheny General Hospital | Pittsburgh | Pennsylvania | 15212 | — |
| Pinnacle Health Cardiovascular Institute/ UPMC Pinnacle Harrisburg | Wormleysburg | Pennsylvania | 17043 | — |
| Lankenau Medical Center | Wynnewood | Pennsylvania | 19096 | — |
| WellSpan York Hospital | York | Pennsylvania | 17405 | — |
| CVA Heart Institute Kingsport | Kingsport | Tennessee | 37660 | — |
| Baptist Memorial Hospital Memphis | Memphis | Tennessee | 38138 | — |
| Centennial Medical Center | Nashville | Tennessee | 37203 | — |
| Saint Thomas Heart at Saint Thomas West | Nashville | Tennessee | 37205 | — |
| Vanderbilt University Medical Center | Nashville | Tennessee | 37232 | — |
| Baylor College of Medicine | Houston | Texas | 77030 | — |
| Houston Methodist Hospital | Houston | Texas | 77030 | — |
| The University of Texas Health Science Center at Houston | Houston | Texas | 77030 | — |
| The Heart Hospital Baylor Plano | Plano | Texas | 75093 | — |
| Intermountain Medical Center | Salt Lake City | Utah | 84107 | — |
| University of Virginia | Charlottesville | Virginia | 22908 | — |
| Sentara Norfolk General Hospital | Norfolk | Virginia | 23507 | — |
| Swedish Medical Center | Seattle | Washington | 98122 | — |
| Aurora St. Luke's Medical Center | Milwaukee | Wisconsin | 53215 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 18 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT03706833, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jul 8, 2026 · Synced Oct 19, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT03706833 live on ClinicalTrials.gov.